USP34 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071108Biological processprotein K48-linked deubiquitination
GO_0016055Biological processWnt signaling pathway
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0006508Biological processproteolysis
GO_0016579Biological processprotein deubiquitination
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameUSP34
Protein nameUbiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)
Ubiquitin specific peptidase 34
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34)
SynonymsKIAA0729
KIAA0570
DescriptionFUNCTION: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. .

FUNCTION: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. .

AccessionsH7C150
ENST00000436269.1
Q70CQ2
ENST00000411912.5
H7BZ73
ENST00000398571.7 [Q70CQ2-1]
ENST00000453734.1
H7C183
A0A0C4DG73
ENST00000453133.1