GSKIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0030111Biological processregulation of Wnt signaling pathway
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0034237Molecular functionprotein kinase A regulatory subunit binding
GO_0019901Molecular functionprotein kinase binding
GO_0051018Molecular functionprotein kinase A binding
GO_0005515Molecular functionprotein binding
GO_0008013Molecular functionbeta-catenin binding
GO_0019207Molecular functionkinase regulator activity

IV. Literature review

[source]
Gene nameGSKIP
Protein nameGSK3B interacting protein
GSK3B-interacting protein (GSKIP) (GSK3beta interaction protein)
SynonymsC14orf129
HSPC210
DescriptionFUNCTION: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets . The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively . Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B . During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression . .

AccessionsENST00000556095.5
ENST00000555181.6
G3V368
Q9P0R6
ENST00000553699.5
ENST00000438650.5
G3V4I5
ENST00000555757.1
ENST00000554182.5