TMEM9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015031Biological processprotein transport
GO_0042176Biological processregulation of protein catabolic process
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0007042Biological processlysosomal lumen acidification
GO_0048388Biological processendosomal lumen acidification
GO_0070070Biological processproton-transporting V-type ATPase complex assembly
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005764Cellular componentlysosome
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0032585Cellular componentmultivesicular body membrane
GO_0072686Cellular componentmitotic spindle
GO_0005765Cellular componentlysosomal membrane
GO_0005770Cellular componentlate endosome
GO_0045171Cellular componentintercellular bridge
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameTMEM9
Protein nameTMEM9 protein
Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9)
Transmembrane protein 9
SynonymsDERP4
HSPC186
UNQ631/PRO1248
PSEC0012
TMEM9A
DescriptionFUNCTION: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking . By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation . TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC . In the liver, involved in hepatic regeneration . .

AccessionsENST00000435310.5
ENST00000455367.5
ENST00000367334.9
Q6FIF9
ENST00000367333.6
B1ALM5
F2Z389
ENST00000497582.5
Q6IAJ3
ENST00000367330.6
Q9P0T7
B1ALM4
ENST00000367332.5
B1ALM8
ENST00000414605.2
ENST00000485839.6
B1ALM7