Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 13 studies | 30% ± 12% | |
| connective tissue cell | 8 studies | 29% ± 9% | |
| epithelial cell | 8 studies | 37% ± 18% | |
| ciliated cell | 8 studies | 30% ± 8% | |
| endothelial cell | 6 studies | 23% ± 9% | |
| pericyte | 5 studies | 23% ± 6% | |
| smooth muscle cell | 5 studies | 21% ± 4% | |
| myofibroblast cell | 5 studies | 27% ± 9% | |
| type I pneumocyte | 5 studies | 30% ± 10% | |
| abnormal cell | 5 studies | 35% ± 21% | |
| pancreatic A cell | 4 studies | 40% ± 17% | |
| kidney distal convoluted tubule epithelial cell | 4 studies | 26% ± 6% | |
| neuron | 4 studies | 26% ± 7% | |
| basal cell | 4 studies | 29% ± 10% | |
| type B pancreatic cell | 3 studies | 30% ± 6% | |
| progenitor cell | 3 studies | 25% ± 13% | |
| mesothelial cell | 3 studies | 36% ± 10% | |
| type II pneumocyte | 3 studies | 34% ± 11% | |
| astrocyte | 3 studies | 26% ± 11% | |
| retinal cone cell | 3 studies | 41% ± 16% | |
| GABAergic neuron | 3 studies | 34% ± 8% | |
| glutamatergic neuron | 3 studies | 37% ± 14% | |
| interneuron | 3 studies | 26% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 5436.39 | 180 / 180 | 100% | 102.76 | 430 / 430 |
| pancreas | 100% | 2622.49 | 328 / 328 | 100% | 77.10 | 178 / 178 |
| brain | 100% | 5520.95 | 2641 / 2642 | 100% | 123.63 | 705 / 705 |
| prostate | 100% | 4504.60 | 245 / 245 | 100% | 127.19 | 501 / 502 |
| thymus | 100% | 4682.28 | 653 / 653 | 100% | 113.90 | 603 / 605 |
| breast | 100% | 3274.10 | 458 / 459 | 100% | 141.21 | 1115 / 1118 |
| liver | 100% | 2629.53 | 226 / 226 | 100% | 89.05 | 404 / 406 |
| uterus | 100% | 5196.70 | 170 / 170 | 99% | 108.45 | 455 / 459 |
| skin | 100% | 2627.24 | 1807 / 1809 | 99% | 83.18 | 468 / 472 |
| bladder | 100% | 3159.10 | 21 / 21 | 98% | 88.30 | 495 / 504 |
| lung | 100% | 3158.56 | 577 / 578 | 98% | 99.25 | 1135 / 1155 |
| kidney | 100% | 4626.92 | 89 / 89 | 98% | 93.04 | 883 / 901 |
| adrenal gland | 100% | 6660.64 | 258 / 258 | 98% | 109.84 | 225 / 230 |
| intestine | 100% | 2711.74 | 965 / 966 | 97% | 73.85 | 511 / 527 |
| stomach | 100% | 2657.51 | 359 / 359 | 93% | 57.90 | 266 / 286 |
| esophagus | 100% | 2527.49 | 1443 / 1445 | 91% | 39.19 | 167 / 183 |
| eye | 0% | 0 | 0 / 0 | 100% | 79.65 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 38.48 | 29 / 29 |
| spleen | 100% | 2212.20 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 60.71 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 78.14 | 1 / 1 |
| blood vessel | 100% | 3011.94 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2347.52 | 1200 / 1204 | 0% | 0 | 0 / 0 |
| heart | 95% | 1928.79 | 821 / 861 | 0% | 0 | 0 / 0 |
| muscle | 94% | 1712.70 | 751 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 63% | 940.57 | 585 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0015031 | Biological process | protein transport |
| GO_0042176 | Biological process | regulation of protein catabolic process |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0007042 | Biological process | lysosomal lumen acidification |
| GO_0048388 | Biological process | endosomal lumen acidification |
| GO_0070070 | Biological process | proton-transporting V-type ATPase complex assembly |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0005764 | Cellular component | lysosome |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_0032585 | Cellular component | multivesicular body membrane |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0005770 | Cellular component | late endosome |
| GO_0045171 | Cellular component | intercellular bridge |
| GO_0005515 | Molecular function | protein binding |
| GO_0003674 | Molecular function | molecular_function |
| Gene name | TMEM9 |
| Protein name | TMEM9 protein Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9) Transmembrane protein 9 |
| Synonyms | DERP4 HSPC186 UNQ631/PRO1248 PSEC0012 TMEM9A |
| Description | FUNCTION: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking . By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation . TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC . In the liver, involved in hepatic regeneration . . |
| Accessions | ENST00000435310.5 ENST00000455367.5 ENST00000367334.9 Q6FIF9 ENST00000367333.6 B1ALM5 F2Z389 ENST00000497582.5 Q6IAJ3 ENST00000367330.6 Q9P0T7 B1ALM4 ENST00000367332.5 B1ALM8 ENST00000414605.2 ENST00000485839.6 B1ALM7 |