Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 13 studies | 30% ± 12% | |
connective tissue cell | 8 studies | 29% ± 9% | |
epithelial cell | 8 studies | 37% ± 18% | |
ciliated cell | 8 studies | 30% ± 8% | |
endothelial cell | 6 studies | 23% ± 9% | |
pericyte | 5 studies | 23% ± 6% | |
smooth muscle cell | 5 studies | 21% ± 4% | |
myofibroblast cell | 5 studies | 27% ± 9% | |
type I pneumocyte | 5 studies | 30% ± 10% | |
abnormal cell | 5 studies | 35% ± 21% | |
pancreatic A cell | 4 studies | 40% ± 17% | |
kidney distal convoluted tubule epithelial cell | 4 studies | 26% ± 6% | |
neuron | 4 studies | 26% ± 7% | |
basal cell | 4 studies | 29% ± 10% | |
type B pancreatic cell | 3 studies | 30% ± 6% | |
progenitor cell | 3 studies | 25% ± 13% | |
mesothelial cell | 3 studies | 36% ± 10% | |
type II pneumocyte | 3 studies | 34% ± 11% | |
astrocyte | 3 studies | 26% ± 11% | |
retinal cone cell | 3 studies | 41% ± 16% | |
GABAergic neuron | 3 studies | 34% ± 8% | |
glutamatergic neuron | 3 studies | 37% ± 14% | |
interneuron | 3 studies | 26% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 5436.39 | 180 / 180 | 100% | 102.76 | 430 / 430 |
pancreas | 100% | 2622.49 | 328 / 328 | 100% | 77.10 | 178 / 178 |
brain | 100% | 5520.95 | 2641 / 2642 | 100% | 123.63 | 705 / 705 |
prostate | 100% | 4504.60 | 245 / 245 | 100% | 127.19 | 501 / 502 |
thymus | 100% | 4682.28 | 653 / 653 | 100% | 113.90 | 603 / 605 |
breast | 100% | 3274.10 | 458 / 459 | 100% | 141.21 | 1115 / 1118 |
liver | 100% | 2629.53 | 226 / 226 | 100% | 89.05 | 404 / 406 |
uterus | 100% | 5196.70 | 170 / 170 | 99% | 108.45 | 455 / 459 |
skin | 100% | 2627.24 | 1807 / 1809 | 99% | 83.18 | 468 / 472 |
bladder | 100% | 3159.10 | 21 / 21 | 98% | 88.30 | 495 / 504 |
lung | 100% | 3158.56 | 577 / 578 | 98% | 99.25 | 1135 / 1155 |
kidney | 100% | 4626.92 | 89 / 89 | 98% | 93.04 | 883 / 901 |
adrenal gland | 100% | 6660.64 | 258 / 258 | 98% | 109.84 | 225 / 230 |
intestine | 100% | 2711.74 | 965 / 966 | 97% | 73.85 | 511 / 527 |
stomach | 100% | 2657.51 | 359 / 359 | 93% | 57.90 | 266 / 286 |
esophagus | 100% | 2527.49 | 1443 / 1445 | 91% | 39.19 | 167 / 183 |
eye | 0% | 0 | 0 / 0 | 100% | 79.65 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 38.48 | 29 / 29 |
spleen | 100% | 2212.20 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 60.71 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 78.14 | 1 / 1 |
blood vessel | 100% | 3011.94 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 2347.52 | 1200 / 1204 | 0% | 0 | 0 / 0 |
heart | 95% | 1928.79 | 821 / 861 | 0% | 0 | 0 / 0 |
muscle | 94% | 1712.70 | 751 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 63% | 940.57 | 585 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0015031 | Biological process | protein transport |
GO_0042176 | Biological process | regulation of protein catabolic process |
GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
GO_0007042 | Biological process | lysosomal lumen acidification |
GO_0048388 | Biological process | endosomal lumen acidification |
GO_0070070 | Biological process | proton-transporting V-type ATPase complex assembly |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0005764 | Cellular component | lysosome |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0032585 | Cellular component | multivesicular body membrane |
GO_0072686 | Cellular component | mitotic spindle |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0005770 | Cellular component | late endosome |
GO_0045171 | Cellular component | intercellular bridge |
GO_0005515 | Molecular function | protein binding |
GO_0003674 | Molecular function | molecular_function |
Gene name | TMEM9 |
Protein name | TMEM9 protein Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9) Transmembrane protein 9 |
Synonyms | DERP4 HSPC186 UNQ631/PRO1248 PSEC0012 TMEM9A |
Description | FUNCTION: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking . By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation . TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC . In the liver, involved in hepatic regeneration . . |
Accessions | ENST00000435310.5 ENST00000455367.5 ENST00000367334.9 Q6FIF9 ENST00000367333.6 B1ALM5 F2Z389 ENST00000497582.5 Q6IAJ3 ENST00000367330.6 Q9P0T7 B1ALM4 ENST00000367332.5 B1ALM8 ENST00000414605.2 ENST00000485839.6 B1ALM7 |