SEMA5A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
pericyte	28 studies	37% ± 20%	Explore
oligodendrocyte precursor cell	15 studies	79% ± 14%	Explore
fibroblast	14 studies	25% ± 14%	Explore
smooth muscle cell	13 studies	32% ± 18%	Explore
endothelial cell	10 studies	30% ± 12%	Explore
astrocyte	9 studies	28% ± 16%	Explore
type I pneumocyte	8 studies	48% ± 14%	Explore
basal cell	8 studies	29% ± 13%	Explore
oligodendrocyte	8 studies	31% ± 16%	Explore
epithelial cell	6 studies	27% ± 12%	Explore
retina horizontal cell	6 studies	65% ± 14%	Explore
Mueller cell	6 studies	35% ± 22%	Explore
GABAergic neuron	5 studies	41% ± 13%	Explore
interneuron	5 studies	37% ± 12%	Explore
cardiac muscle cell	5 studies	43% ± 12%	Explore
connective tissue cell	5 studies	34% ± 19%	Explore
glutamatergic neuron	4 studies	29% ± 9%	Explore
myofibroblast cell	4 studies	22% ± 10%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	70% ± 11%	Explore
transit amplifying cell	3 studies	31% ± 17%	Explore
mesothelial cell	3 studies	50% ± 17%	Explore
podocyte	3 studies	87% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	27% ± 11%	Explore
heart	3 studies	26% ± 5%	Explore
lung	3 studies	17% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	1854.58	2507 / 2642	99%	44.05	696 / 705
kidney	100%	3423.74	89 / 89	89%	20.33	805 / 901
skin	98%	1934.45	1770 / 1809	82%	27.31	389 / 472
bladder	100%	2327.62	21 / 21	77%	21.92	388 / 504
breast	98%	2562.99	451 / 459	77%	11.60	861 / 1118
intestine	85%	1288.90	821 / 966	79%	12.54	418 / 527
pancreas	86%	611.46	282 / 328	74%	11.40	132 / 178
lung	100%	2938.36	578 / 578	47%	6.56	545 / 1155
uterus	100%	2447.80	170 / 170	44%	8.90	200 / 459
esophagus	84%	807.63	1209 / 1445	55%	5.72	100 / 183
thymus	96%	974.93	629 / 653	40%	3.22	242 / 605
prostate	98%	1151.44	239 / 245	32%	2.42	159 / 502
stomach	48%	280.99	171 / 359	77%	11.89	219 / 286
ovary	69%	515.99	125 / 180	38%	3.38	164 / 430
ureter	0%	0	0 / 0	100%	41.75	1 / 1
adipose	98%	1941.11	1182 / 1204	0%	0	0 / 0
liver	65%	468.77	148 / 226	32%	2.74	131 / 406
heart	95%	1854.61	820 / 861	0%	0	0 / 0
blood vessel	95%	1444.40	1262 / 1335	0%	0	0 / 0
spleen	94%	1038.43	227 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	64%	10.33	29 / 45
adrenal gland	26%	166.16	67 / 258	28%	2.47	64 / 230
eye	0%	0	0 / 0	50%	5.73	40 / 80
muscle	21%	111.24	166 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	17%	0.97	5 / 29
peripheral blood	1%	5.42	7 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000352	Biological process	negative regulation of endothelial cell apoptotic process
GO_0001755	Biological process	neural crest cell migration
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0050918	Biological process	positive chemotaxis
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0021536	Biological process	diencephalon development
GO_0007155	Biological process	cell adhesion
GO_1990256	Biological process	signal clustering
GO_0007267	Biological process	cell-cell signaling
GO_0050919	Biological process	negative chemotaxis
GO_0007413	Biological process	axonal fasciculation
GO_0002043	Biological process	blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO_0030335	Biological process	positive regulation of cell migration
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_2001028	Biological process	positive regulation of endothelial cell chemotaxis
GO_0048675	Biological process	axon extension
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0030836	Biological process	positive regulation of actin filament depolymerization
GO_0071526	Biological process	semaphorin-plexin signaling pathway
GO_0048842	Biological process	positive regulation of axon extension involved in axon guidance
GO_0007399	Biological process	nervous system development
GO_0060326	Biological process	cell chemotaxis
GO_0007411	Biological process	axon guidance
GO_0048843	Biological process	negative regulation of axon extension involved in axon guidance
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0035373	Molecular function	chondroitin sulfate proteoglycan binding
GO_0030215	Molecular function	semaphorin receptor binding
GO_0045545	Molecular function	syndecan binding
GO_0043395	Molecular function	heparan sulfate proteoglycan binding
GO_0045499	Molecular function	chemorepellent activity

IV. Literature review

[source]

Gene name	SEMA5A
Protein name	Semaphorin 5A isoform B Semaphorin-5A (Semaphorin-F) (Sema F) Semaphorin 5A isoform A Semaphorin 5A
Synonyms	SEMAF
Description	FUNCTION: Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. .
Accessions	Q13591 X5DR95 ENST00000652226.1 ENST00000382496.10 ENST00000513968.4 D6RAF4 X5DPA6

SEMA5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review