FGFR2 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	17 studies	43% ± 20%	Explore
oligodendrocyte	17 studies	57% ± 20%	Explore
basal cell	8 studies	38% ± 20%	Explore
epithelial cell	7 studies	45% ± 16%	Explore
type II pneumocyte	7 studies	35% ± 13%	Explore
type I pneumocyte	6 studies	25% ± 11%	Explore
club cell	6 studies	32% ± 11%	Explore
fibroblast	4 studies	40% ± 21%	Explore
retinal pigment epithelial cell	4 studies	42% ± 20%	Explore
respiratory goblet cell	4 studies	43% ± 23%	Explore
goblet cell	4 studies	37% ± 10%	Explore
cholangiocyte	3 studies	65% ± 22%	Explore
endothelial cell	3 studies	41% ± 23%	Explore
microglial cell	3 studies	16% ± 1%	Explore
ciliated cell	3 studies	26% ± 2%	Explore
GABAergic neuron	3 studies	27% ± 0%	Explore
glutamatergic neuron	3 studies	24% ± 7%	Explore
ependymal cell	3 studies	35% ± 8%	Explore
chondrocyte	3 studies	37% ± 4%	Explore
mucus secreting cell	3 studies	39% ± 17%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	13 studies	31% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	7089.19	2629 / 2642	93%	31.08	656 / 705
thymus	100%	4840.36	651 / 653	92%	28.14	558 / 605
ovary	89%	2782.04	161 / 180	98%	32.17	421 / 430
pancreas	98%	2261.48	321 / 328	83%	14.43	147 / 178
esophagus	97%	3192.47	1404 / 1445	83%	25.70	152 / 183
uterus	100%	6176.61	170 / 170	78%	21.70	357 / 459
kidney	94%	2396.74	84 / 89	78%	14.99	702 / 901
prostate	96%	3475.22	236 / 245	70%	15.43	351 / 502
bladder	95%	2665.52	20 / 21	61%	14.02	305 / 504
liver	92%	2091.33	207 / 226	63%	30.24	255 / 406
breast	69%	1928.51	317 / 459	80%	31.41	894 / 1118
intestine	96%	5140.36	926 / 966	46%	8.10	242 / 527
lung	62%	1417.08	356 / 578	76%	28.94	873 / 1155
adrenal gland	99%	3206.46	256 / 258	28%	4.15	64 / 230
stomach	67%	1159.46	242 / 359	58%	20.78	165 / 286
tonsil	0%	0	0 / 0	93%	26.54	42 / 45
skin	72%	5369.89	1303 / 1809	4%	1.11	17 / 472
blood vessel	61%	1263.18	816 / 1335	0%	0	0 / 0
adipose	30%	444.15	362 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	8%	0.62	6 / 80
heart	4%	45.17	36 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0060442	Biological process	branching involved in prostate gland morphogenesis
GO_0071560	Biological process	cellular response to transforming growth factor beta stimulus
GO_0030324	Biological process	lung development
GO_0060349	Biological process	bone morphogenesis
GO_0060527	Biological process	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO_0042476	Biological process	odontogenesis
GO_0030916	Biological process	otic vesicle formation
GO_0070372	Biological process	regulation of ERK1 and ERK2 cascade
GO_0045667	Biological process	regulation of osteoblast differentiation
GO_0032808	Biological process	lacrimal gland development
GO_0007275	Biological process	multicellular organism development
GO_0003149	Biological process	membranous septum morphogenesis
GO_0060915	Biological process	mesenchymal cell differentiation involved in lung development
GO_0007267	Biological process	cell-cell signaling
GO_0002053	Biological process	positive regulation of mesenchymal cell proliferation
GO_0060667	Biological process	branch elongation involved in salivary gland morphogenesis
GO_0060601	Biological process	lateral sprouting from an epithelium
GO_0060615	Biological process	mammary gland bud formation
GO_0048701	Biological process	embryonic cranial skeleton morphogenesis
GO_0010518	Biological process	positive regulation of phospholipase activity
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0003416	Biological process	endochondral bone growth
GO_0035607	Biological process	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO_0060512	Biological process	prostate gland morphogenesis
GO_1904707	Biological process	positive regulation of vascular associated smooth muscle cell proliferation
GO_0071300	Biological process	cellular response to retinoic acid
GO_0001525	Biological process	angiogenesis
GO_0051781	Biological process	positive regulation of cell division
GO_0001657	Biological process	ureteric bud development
GO_0060529	Biological process	squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO_0048730	Biological process	epidermis morphogenesis
GO_0001701	Biological process	in utero embryonic development
GO_0030855	Biological process	epithelial cell differentiation
GO_0035603	Biological process	fibroblast growth factor receptor signaling pathway involved in hemopoiesis
GO_0055010	Biological process	ventricular cardiac muscle tissue morphogenesis
GO_0016331	Biological process	morphogenesis of embryonic epithelium
GO_0010839	Biological process	negative regulation of keratinocyte proliferation
GO_0060463	Biological process	lung lobe morphogenesis
GO_0035602	Biological process	fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
GO_0050679	Biological process	positive regulation of epithelial cell proliferation
GO_0045165	Biological process	cell fate commitment
GO_0035604	Biological process	fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
GO_0060670	Biological process	branching involved in labyrinthine layer morphogenesis
GO_0022612	Biological process	gland morphogenesis
GO_0048565	Biological process	digestive tract development
GO_0042472	Biological process	inner ear morphogenesis
GO_0060348	Biological process	bone development
GO_0046777	Biological process	protein autophosphorylation
GO_0060484	Biological process	lung-associated mesenchyme development
GO_0048608	Biological process	reproductive structure development
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0048705	Biological process	skeletal system morphogenesis
GO_0045787	Biological process	positive regulation of cell cycle
GO_0008543	Biological process	fibroblast growth factor receptor signaling pathway
GO_0035265	Biological process	organ growth
GO_0048568	Biological process	embryonic organ development
GO_0003148	Biological process	outflow tract septum morphogenesis
GO_0060664	Biological process	epithelial cell proliferation involved in salivary gland morphogenesis
GO_0060445	Biological process	branching involved in salivary gland morphogenesis
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0021860	Biological process	pyramidal neuron development
GO_0060045	Biological process	positive regulation of cardiac muscle cell proliferation
GO_0060523	Biological process	prostate epithelial cord elongation
GO_0021769	Biological process	orbitofrontal cortex development
GO_0009887	Biological process	animal organ morphogenesis
GO_0060688	Biological process	regulation of morphogenesis of a branching structure
GO_0031069	Biological process	hair follicle morphogenesis
GO_0060174	Biological process	limb bud formation
GO_0048333	Biological process	mesodermal cell differentiation
GO_0045471	Biological process	response to ethanol
GO_0007409	Biological process	axonogenesis
GO_0033674	Biological process	positive regulation of kinase activity
GO_0021847	Biological process	ventricular zone neuroblast division
GO_0060916	Biological process	mesenchymal cell proliferation involved in lung development
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0060595	Biological process	fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO_0030901	Biological process	midbrain development
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0048286	Biological process	lung alveolus development
GO_0008589	Biological process	regulation of smoothened signaling pathway
GO_0001837	Biological process	epithelial to mesenchymal transition
GO_0060501	Biological process	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO_0007169	Biological process	cell surface receptor protein tyrosine kinase signaling pathway
GO_0009791	Biological process	post-embryonic development
GO_0060449	Biological process	bud elongation involved in lung branching
GO_0048562	Biological process	embryonic organ morphogenesis
GO_0048762	Biological process	mesenchymal cell differentiation
GO_0033688	Biological process	regulation of osteoblast proliferation
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0018108	Biological process	peptidyl-tyrosine phosphorylation
GO_0009880	Biological process	embryonic pattern specification
GO_0048557	Biological process	embryonic digestive tract morphogenesis
GO_0030282	Biological process	bone mineralization
GO_0006915	Biological process	apoptotic process
GO_0048755	Biological process	branching morphogenesis of a nerve
GO_0051150	Biological process	regulation of smooth muscle cell differentiation
GO_0032496	Biological process	response to lipopolysaccharide
GO_0071456	Biological process	cellular response to hypoxia
GO_0009986	Cellular component	cell surface
GO_0060076	Cellular component	excitatory synapse
GO_0005634	Cellular component	nucleus
GO_0005576	Cellular component	extracellular region
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005737	Cellular component	cytoplasm
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005938	Cellular component	cell cortex
GO_0005524	Molecular function	ATP binding
GO_0008201	Molecular function	heparin binding
GO_0004713	Molecular function	protein tyrosine kinase activity
GO_0005515	Molecular function	protein binding
GO_0042803	Molecular function	protein homodimerization activity
GO_0005007	Molecular function	fibroblast growth factor receptor activity
GO_0017134	Molecular function	fibroblast growth factor binding

IV. Literature review

[source]

Gene name	FGFR2
Protein name	Alternative protein FGFR2 Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) Soluble FGFR2 variant 3 Fibroblast growth factor receptor 2 Ksam IV secreted isoform (Fibroblast growth factor receptor 2 isoform IgIIIb isoform) Fibroblast growth factor receptor 2 (EC 2.7.10.1) Soluble FGFR2 variant 1 Fibroblast growth factor receptor 2 isoform IgIIIc isoform Soluble FGFR2 variant 2 Soluble FGFR4 variant 4 Fibroblast growth factor receptor (EC 2.7.10.1) Fibroblast growth factor receptor 2
Synonyms	hCG_1811153 BEK KSAM KGFR
Description	FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. .
Accessions	A0A141AXF2 ENST00000351936.11 [P21802-5] ENST00000613324.4 A0A804HIH8 ENST00000682550.1 [P21802-20] ENST00000683211.1 [P21802-5] ENST00000683250.1 ENST00000613048.4 ENST00000336553.10 ENST00000357555.9 [P21802-21] ENST00000356226.8 [P21802-20] ENST00000358487.10 [P21802-1] A0A1B0GYB8 ENST00000478859.5 ENST00000457416.7 [P21802-3] ENST00000369061.8 [P21802-23] B5A960 ENST00000636922.1 A0A5S6RJB7 A0A141AXF4 H7C265 S4R3B2 A0A087X2D1 ENST00000684153.1 S4R381 ENST00000346997.6 [P21802-5] E7EVR7 A0A141AXF6 ENST00000369059.5 A0A1B0GYP7 A0A141AXF0 ENST00000369056.5 [P21802-17] B5A961 A0A804HI10 ENST00000359354.6 [P21802-14] B5A962 B5A963 ENST00000638709.2 A0A141AXF1 A0A141AXF5 ENST00000360144.7 [P21802-22] A0A141AXF8 D2CGD1 H7BXU9 A0A087WY21 ENST00000611527.1 ENST00000369060.8 [P21802-15] A0A1W2PQT9 E2I6F9 ENST00000429361.5 A0A141AXF3 A0A141AXF7 A0A1B0GWF4 A0A0A0MR25 ENST00000369058.7 ENST00000682772.1 L8E8R5 ENST00000604236.5 ENST00000351936 ENST00000683035.1 L8E779 P21802 A0A804HI76

FGFR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review