XIAP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0070427Biological processnucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0046330Biological processpositive regulation of JNK cascade
GO_0030510Biological processregulation of BMP signaling pathway
GO_0006974Biological processDNA damage response
GO_0032481Biological processpositive regulation of type I interferon production
GO_0050727Biological processregulation of inflammatory response
GO_0045088Biological processregulation of innate immune response
GO_0051402Biological processneuron apoptotic process
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0042742Biological processdefense response to bacterium
GO_0070424Biological processregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_0097340Biological processinhibition of cysteine-type endopeptidase activity
GO_0070431Biological processnucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_1902530Biological processpositive regulation of protein linear polyubiquitination
GO_0016055Biological processWnt signaling pathway
GO_0055070Biological processcopper ion homeostasis
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0042127Biological processregulation of cell population proliferation
GO_0051726Biological processregulation of cell cycle
GO_0060785Biological processregulation of apoptosis involved in tissue homeostasis
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004869Molecular functioncysteine-type endopeptidase inhibitor activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0043027Molecular functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0042802Molecular functionidentical protein binding
GO_0120283Molecular functionprotein serine/threonine kinase binding
GO_0061135Molecular functionendopeptidase regulator activity
GO_0046872Molecular functionmetal ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameXIAP
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
E3 ubiquitin-protein ligase XIAP
SynonymsBIRC4
IAP3
API3
DescriptionFUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis . Acts as a direct caspase inhibitor . Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry . Inactivates CASP9 by keeping it in a monomeric, inactive state . Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS, PTEN and BIRC5/survivin . Acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling . 'Lys-63'-linked polyubiquitination of RIPK2 also promotes recruitment of the LUBAC complex to RIPK2 . Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation . Ubiquitination of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation . Ubiquitination of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation . Plays a role in copper homeostasis by ubiquitinating COMMD1 and promoting its proteasomal degradation . Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation . Ubiquitinates and therefore mediates the proteasomal degradation of BCL2 in response to apoptosis . Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner . Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8 . Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES . Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program . .

AccessionsENST00000355640.3
ENST00000371199.8
ENST00000430625.1
ENST00000422098.5
ENST00000422098.6
B1AKU2
P98170
B1AKU3