ATP6AP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	38 studies	42% ± 14%	Explore
fibroblast	33 studies	38% ± 12%	Explore
endothelial cell	32 studies	28% ± 12%	Explore
natural killer cell	31 studies	27% ± 8%	Explore
conventional dendritic cell	26 studies	35% ± 16%	Explore
pericyte	25 studies	34% ± 11%	Explore
classical monocyte	25 studies	43% ± 15%	Explore
smooth muscle cell	23 studies	31% ± 10%	Explore
non-classical monocyte	23 studies	43% ± 14%	Explore
CD8-positive, alpha-beta T cell	22 studies	24% ± 8%	Explore
CD4-positive, alpha-beta T cell	22 studies	24% ± 8%	Explore
T cell	20 studies	22% ± 5%	Explore
monocyte	20 studies	34% ± 14%	Explore
regulatory T cell	18 studies	24% ± 6%	Explore
connective tissue cell	17 studies	33% ± 11%	Explore
gamma-delta T cell	15 studies	28% ± 9%	Explore
ciliated cell	14 studies	33% ± 15%	Explore
B cell	14 studies	23% ± 7%	Explore
dendritic cell	13 studies	33% ± 20%	Explore
endothelial cell of lymphatic vessel	13 studies	30% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	32% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	25% ± 7%	Explore
mature NK T cell	13 studies	27% ± 6%	Explore
myofibroblast cell	13 studies	36% ± 11%	Explore
plasmacytoid dendritic cell	13 studies	29% ± 10%	Explore
basal cell	12 studies	34% ± 16%	Explore
astrocyte	12 studies	28% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	27% ± 7%	Explore
epithelial cell	11 studies	38% ± 21%	Explore
myeloid cell	11 studies	45% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 8%	Explore
naive B cell	10 studies	20% ± 2%	Explore
capillary endothelial cell	10 studies	23% ± 5%	Explore
endothelial cell of artery	10 studies	27% ± 6%	Explore
vein endothelial cell	10 studies	23% ± 8%	Explore
glutamatergic neuron	10 studies	35% ± 18%	Explore
mucosal invariant T cell	10 studies	27% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	24% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	30% ± 7%	Explore
endothelial cell of vascular tree	9 studies	24% ± 6%	Explore
alveolar macrophage	8 studies	37% ± 15%	Explore
type I pneumocyte	8 studies	25% ± 10%	Explore
plasma cell	8 studies	32% ± 11%	Explore
leukocyte	8 studies	26% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	29% ± 10%	Explore
oligodendrocyte	8 studies	22% ± 4%	Explore
oligodendrocyte precursor cell	8 studies	28% ± 11%	Explore
mast cell	7 studies	20% ± 6%	Explore
secretory cell	7 studies	29% ± 13%	Explore
abnormal cell	7 studies	30% ± 8%	Explore
neuron	7 studies	34% ± 11%	Explore
plasmablast	6 studies	43% ± 25%	Explore
mononuclear phagocyte	6 studies	44% ± 14%	Explore
renal alpha-intercalated cell	6 studies	78% ± 24%	Explore
microglial cell	6 studies	28% ± 14%	Explore
innate lymphoid cell	6 studies	30% ± 6%	Explore
T follicular helper cell	6 studies	24% ± 4%	Explore
GABAergic neuron	6 studies	40% ± 15%	Explore
interneuron	6 studies	33% ± 17%	Explore
memory B cell	6 studies	20% ± 2%	Explore
hematopoietic precursor cell	5 studies	31% ± 15%	Explore
ionocyte	5 studies	57% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	24% ± 6%	Explore
kidney loop of Henle epithelial cell	5 studies	34% ± 12%	Explore
epithelial cell of proximal tubule	5 studies	22% ± 7%	Explore
mesothelial cell	5 studies	29% ± 20%	Explore
amacrine cell	5 studies	40% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	27% ± 13%	Explore
club cell	4 studies	32% ± 8%	Explore
pancreatic A cell	4 studies	68% ± 18%	Explore
type B pancreatic cell	4 studies	58% ± 24%	Explore
exhausted T cell	4 studies	28% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	38% ± 9%	Explore
ON-bipolar cell	4 studies	31% ± 15%	Explore
retinal ganglion cell	4 studies	68% ± 20%	Explore
retina horizontal cell	4 studies	48% ± 15%	Explore
adventitial cell	4 studies	36% ± 12%	Explore
intermediate monocyte	4 studies	49% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	28% ± 5%	Explore
erythrocyte	4 studies	30% ± 19%	Explore
hematopoietic stem cell	4 studies	22% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 10%	Explore
respiratory goblet cell	3 studies	29% ± 16%	Explore
pancreatic D cell	3 studies	59% ± 21%	Explore
glomerular endothelial cell	3 studies	25% ± 9%	Explore
progenitor cell	3 studies	23% ± 5%	Explore
renal beta-intercalated cell	3 studies	76% ± 32%	Explore
retinal bipolar neuron	3 studies	44% ± 13%	Explore
OFF-bipolar cell	3 studies	33% ± 10%	Explore
GABAergic amacrine cell	3 studies	28% ± 11%	Explore
renal principal cell	3 studies	58% ± 7%	Explore
lymphocyte	3 studies	30% ± 12%	Explore
type II pneumocyte	3 studies	26% ± 12%	Explore
retinal cone cell	3 studies	38% ± 12%	Explore
retinal rod cell	3 studies	28% ± 10%	Explore
tissue-resident macrophage	3 studies	39% ± 15%	Explore
intraepithelial lymphocyte	3 studies	28% ± 8%	Explore
Mueller cell	3 studies	41% ± 2%	Explore
rod bipolar cell	3 studies	33% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	27% ± 7%	Explore
CD4-positive helper T cell	3 studies	22% ± 5%	Explore
inflammatory macrophage	3 studies	32% ± 11%	Explore
pancreatic ductal cell	3 studies	61% ± 19%	Explore
granulocyte	3 studies	19% ± 5%	Explore
enteroendocrine cell	3 studies	33% ± 19%	Explore
goblet cell	3 studies	30% ± 8%	Explore
glial cell	3 studies	38% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 8%	Explore
neutrophil	3 studies	26% ± 7%	Explore
double negative thymocyte	3 studies	37% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	32% ± 10%	Explore
lung	16 studies	32% ± 11%	Explore
brain	13 studies	29% ± 13%	Explore
kidney	9 studies	27% ± 7%	Explore
eye	7 studies	32% ± 12%	Explore
intestine	6 studies	28% ± 14%	Explore
bone marrow	5 studies	20% ± 4%	Explore
pancreas	4 studies	55% ± 22%	Explore
placenta	4 studies	27% ± 8%	Explore
uterus	4 studies	41% ± 14%	Explore
lymph node	4 studies	29% ± 10%	Explore
breast	4 studies	25% ± 1%	Explore
liver	3 studies	39% ± 20%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5505.09	1445 / 1445	100%	43.35	183 / 183
uterus	100%	7339.11	170 / 170	100%	59.59	459 / 459
breast	100%	6535.32	459 / 459	100%	81.15	1117 / 1118
kidney	100%	8189.13	89 / 89	100%	78.07	900 / 901
thymus	100%	11237.48	653 / 653	100%	91.95	604 / 605
lung	100%	7014.01	577 / 578	100%	59.37	1155 / 1155
bladder	100%	5782.67	21 / 21	100%	55.20	503 / 504
brain	100%	7455.90	2636 / 2642	100%	69.01	705 / 705
prostate	100%	5119.64	245 / 245	100%	46.58	500 / 502
ovary	100%	5631.81	180 / 180	100%	46.34	428 / 430
intestine	100%	5660.62	966 / 966	99%	47.37	523 / 527
skin	100%	8742.18	1809 / 1809	99%	61.96	468 / 472
stomach	99%	3583.86	355 / 359	100%	47.82	286 / 286
adrenal gland	100%	6085.40	258 / 258	98%	64.35	226 / 230
liver	98%	2904.37	222 / 226	99%	31.60	403 / 406
pancreas	85%	1783.17	279 / 328	99%	53.38	176 / 178
adipose	100%	6993.14	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10218.09	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	45.16	29 / 29
spleen	100%	5176.74	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.27	45 / 45
ureter	0%	0	0 / 0	100%	24.75	1 / 1
peripheral blood	95%	4573.86	883 / 929	0%	0	0 / 0
heart	93%	3037.97	805 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	93%	31.13	74 / 80
muscle	57%	1002.63	460 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032914	Biological process	positive regulation of transforming growth factor beta1 production
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0048388	Biological process	endosomal lumen acidification
GO_0007042	Biological process	lysosomal lumen acidification
GO_0051452	Biological process	intracellular pH reduction
GO_0097401	Biological process	synaptic vesicle lumen acidification
GO_0002003	Biological process	angiotensin maturation
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0021903	Biological process	rostrocaudal neural tube patterning
GO_0048069	Biological process	eye pigmentation
GO_0007035	Biological process	vacuolar acidification
GO_0061795	Biological process	Golgi lumen acidification
GO_0021626	Biological process	central nervous system maturation
GO_0043408	Biological process	regulation of MAPK cascade
GO_0060323	Biological process	head morphogenesis
GO_1902600	Biological process	proton transmembrane transport
GO_0009897	Cellular component	external side of plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005764	Cellular component	lysosome
GO_0000421	Cellular component	autophagosome membrane
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0070062	Cellular component	extracellular exosome
GO_0033176	Cellular component	proton-transporting V-type ATPase complex
GO_0000139	Cellular component	Golgi membrane
GO_0070821	Cellular component	tertiary granule membrane
GO_0032591	Cellular component	dendritic spine membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0045211	Cellular component	postsynaptic membrane
GO_0000220	Cellular component	vacuolar proton-transporting V-type ATPase, V0 domain
GO_0010008	Cellular component	endosome membrane
GO_0030424	Cellular component	axon
GO_0016471	Cellular component	vacuolar proton-transporting V-type ATPase complex
GO_0005765	Cellular component	lysosomal membrane
GO_0030665	Cellular component	clathrin-coated vesicle membrane
GO_0038023	Molecular function	signaling receptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ATP6AP2
Protein name	ATPase H+ transporting accessory protein 2 Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (Renin/prorenin receptor) Renin receptor (ATPase H(+)-transporting lysosomal accessory protein 2) (ATPase H(+)-transporting lysosomal-interacting protein 2) (ER-localized type I transmembrane adapter) (Embryonic liver differentiation factor 10) (N14F) (Renin/prorenin receptor) (Vacuolar ATP synthase membrane sector-associated protein M8-9) (ATP6M8-9) (V-ATPase M8.9 subunit) [Cleaved into: Renin receptor N-terminal fragment; Renin receptor C-terminal fragment]
Synonyms	ATP6IP2 HT028 MSTP009 PSEC0072 ELDF10 CAPER
Description	FUNCTION: Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system . May mediate renin-dependent cellular responses by activating ERK1 and ERK2 . By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) . Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity). .
Accessions	O75787 ENST00000447485.6 A0A1B0GVZ1 ENST00000637482.1 A0A1B0GTU8 A0A1B0GVW0 ENST00000436783.6 A0A1B0GVI9 A0A1B0GWD6 A0A1B0GU12 H7C240 A0A1B0GTD6 ENST00000636251.1 A0A1B0GVB9 ENST00000636574.1 A0A1B0GWJ8 H7C3E1 B7Z1I9 ENST00000423649.2 ENST00000637526.1 A0A1B0GV24 ENST00000635774.1 ENST00000636580.2 [O75787-1] ENST00000636287.1 ENST00000378438.9 ENST00000635734.1 B7Z413 A0A1B0GV60 ENST00000638153.1 ENST00000636787.1 A0A1B0GTB0 A0A1B0GW13 A0A1C7CYW4 ENST00000636196.1 A0A1B0GUV3 ENST00000636639.1 A0A1B0GUT7 ENST00000637955.1 A0A1B0GVC7 ENST00000636970.1 ENST00000486558.6 ENST00000637614.1 ENST00000636409.1 [O75787-2] ENST00000637165.1 ENST00000637327.1

ATP6AP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review