Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| fibroblast | 19 studies | 25% ± 10% | |
| astrocyte | 16 studies | 42% ± 21% | |
| ciliated cell | 14 studies | 34% ± 11% | |
| pericyte | 13 studies | 33% ± 14% | |
| endothelial cell | 13 studies | 30% ± 13% | |
| smooth muscle cell | 13 studies | 24% ± 8% | |
| macrophage | 9 studies | 34% ± 13% | |
| myofibroblast cell | 9 studies | 24% ± 6% | |
| GABAergic neuron | 8 studies | 37% ± 15% | |
| oligodendrocyte precursor cell | 8 studies | 29% ± 12% | |
| epithelial cell | 8 studies | 35% ± 16% | |
| retinal rod cell | 7 studies | 33% ± 11% | |
| basal cell | 7 studies | 30% ± 15% | |
| connective tissue cell | 6 studies | 28% ± 13% | |
| microglial cell | 6 studies | 27% ± 10% | |
| retinal cone cell | 6 studies | 37% ± 13% | |
| ionocyte | 5 studies | 40% ± 11% | |
| mesothelial cell | 5 studies | 29% ± 10% | |
| type I pneumocyte | 5 studies | 22% ± 5% | |
| type II pneumocyte | 5 studies | 20% ± 3% | |
| endothelial cell of lymphatic vessel | 5 studies | 19% ± 3% | |
| retinal pigment epithelial cell | 4 studies | 42% ± 17% | |
| cardiac muscle cell | 4 studies | 19% ± 1% | |
| endothelial cell of artery | 4 studies | 18% ± 2% | |
| interneuron | 4 studies | 34% ± 10% | |
| kidney distal convoluted tubule epithelial cell | 4 studies | 27% ± 8% | |
| kidney loop of Henle epithelial cell | 4 studies | 30% ± 8% | |
| glial cell | 3 studies | 25% ± 9% | |
| glutamatergic neuron | 3 studies | 31% ± 6% | |
| pancreatic ductal cell | 3 studies | 47% ± 23% | |
| ependymal cell | 3 studies | 61% ± 17% | |
| club cell | 3 studies | 19% ± 3% | |
| transit amplifying cell | 3 studies | 31% ± 18% | |
| myoepithelial cell | 3 studies | 38% ± 11% | |
| renal alpha-intercalated cell | 3 studies | 28% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 4354.09 | 245 / 245 | 99% | 103.02 | 499 / 502 |
| pancreas | 100% | 3733.80 | 328 / 328 | 96% | 62.69 | 171 / 178 |
| intestine | 100% | 6824.33 | 966 / 966 | 96% | 49.53 | 504 / 527 |
| esophagus | 100% | 9610.48 | 1444 / 1445 | 95% | 49.12 | 174 / 183 |
| skin | 100% | 5356.35 | 1807 / 1809 | 90% | 78.18 | 425 / 472 |
| ovary | 100% | 6513.53 | 180 / 180 | 90% | 63.51 | 385 / 430 |
| brain | 89% | 4159.45 | 2354 / 2642 | 100% | 225.83 | 703 / 705 |
| stomach | 100% | 5376.78 | 359 / 359 | 89% | 45.79 | 254 / 286 |
| lung | 100% | 4176.78 | 576 / 578 | 89% | 58.85 | 1027 / 1155 |
| kidney | 100% | 3674.65 | 89 / 89 | 87% | 47.56 | 787 / 901 |
| thymus | 99% | 2245.40 | 645 / 653 | 87% | 37.41 | 526 / 605 |
| bladder | 100% | 7055.67 | 21 / 21 | 86% | 51.33 | 432 / 504 |
| uterus | 100% | 3455.01 | 170 / 170 | 82% | 56.61 | 375 / 459 |
| breast | 100% | 3552.75 | 458 / 459 | 70% | 38.73 | 779 / 1118 |
| adrenal gland | 100% | 3869.83 | 258 / 258 | 49% | 27.77 | 112 / 230 |
| adipose | 100% | 2875.49 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 3360.15 | 1328 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 98% | 2308.61 | 236 / 241 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 71.65 | 78 / 80 |
| heart | 92% | 2862.98 | 792 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 40.73 | 35 / 45 |
| liver | 38% | 470.12 | 85 / 226 | 36% | 14.28 | 147 / 406 |
| peripheral blood | 59% | 1750.78 | 547 / 929 | 0% | 0 | 0 / 0 |
| muscle | 25% | 292.17 | 204 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 1.31 | 2 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0009948 | Biological process | anterior/posterior axis specification |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_0006886 | Biological process | intracellular protein transport |
| GO_0031017 | Biological process | exocrine pancreas development |
| GO_0001707 | Biological process | mesoderm formation |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0061357 | Biological process | positive regulation of Wnt protein secretion |
| GO_0071529 | Biological process | cementum mineralization |
| GO_0030902 | Biological process | hindbrain development |
| GO_0016055 | Biological process | Wnt signaling pathway |
| GO_0061355 | Biological process | Wnt protein secretion |
| GO_0030177 | Biological process | positive regulation of Wnt signaling pathway |
| GO_0030901 | Biological process | midbrain development |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0012505 | Cellular component | endomembrane system |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005769 | Cellular component | early endosome |
| GO_0030666 | Cellular component | endocytic vesicle membrane |
| GO_0031901 | Cellular component | early endosome membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0031090 | Cellular component | organelle membrane |
| GO_0017147 | Molecular function | Wnt-protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | WLS |
| Protein name | Alternative protein WLS Putative NFkB activating protein (Wnt ligand secretion mediator) Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373) Wnt ligand secretion mediator |
| Synonyms | UNQ85/PRO18667 GPR177 C1orf139 |
| Description | FUNCTION: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins . Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). . |
| Accessions | ENST00000370976.7 [Q5T9L3-3] ENST00000370973.2 Q5T9L3 ENST00000530486.5 Q7Z430 ENST00000354777.6 [Q5T9L3-2] H0YCG9 ENST00000471243.2 E9PM23 ENST00000370971.1 E9PJW4 ENST00000534713.5 ENST00000491076.1 ENST00000533537.5 L8E8F2 E9PM62 ENST00000262348.9 [Q5T9L3-1] E9PKJ0 E9PQK1 |