WLS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009948Biological processanterior/posterior axis specification
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0006886Biological processintracellular protein transport
GO_0031017Biological processexocrine pancreas development
GO_0001707Biological processmesoderm formation
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0061357Biological processpositive regulation of Wnt protein secretion
GO_0071529Biological processcementum mineralization
GO_0030902Biological processhindbrain development
GO_0016055Biological processWnt signaling pathway
GO_0061355Biological processWnt protein secretion
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0030901Biological processmidbrain development
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0012505Cellular componentendomembrane system
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0030666Cellular componentendocytic vesicle membrane
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0031090Cellular componentorganelle membrane
GO_0017147Molecular functionWnt-protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWLS
Protein nameAlternative protein WLS
Putative NFkB activating protein (Wnt ligand secretion mediator)
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)
Wnt ligand secretion mediator
SynonymsUNQ85/PRO18667
GPR177
C1orf139
DescriptionFUNCTION: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins . Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). .

AccessionsENST00000370976.7 [Q5T9L3-3]
ENST00000370973.2
Q5T9L3
ENST00000530486.5
Q7Z430
ENST00000354777.6 [Q5T9L3-2]
H0YCG9
ENST00000471243.2
E9PM23
ENST00000370971.1
E9PJW4
ENST00000534713.5
ENST00000491076.1
ENST00000533537.5
L8E8F2
E9PM62
ENST00000262348.9 [Q5T9L3-1]
E9PKJ0
E9PQK1