JUP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0045766Biological processpositive regulation of angiogenesis
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_0050982Biological processdetection of mechanical stimulus
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0060070Biological processcanonical Wnt signaling pathway
GO_0043537Biological processnegative regulation of blood vessel endothelial cell migration
GO_0086073Biological processbundle of His cell-Purkinje myocyte adhesion involved in cell communication
GO_0071603Biological processendothelial cell-cell adhesion
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0002159Biological processdesmosome assembly
GO_0098911Biological processregulation of ventricular cardiac muscle cell action potential
GO_0043588Biological processskin development
GO_0098609Biological processcell-cell adhesion
GO_0016477Biological processcell migration
GO_0042127Biological processregulation of cell population proliferation
GO_0071681Biological processcellular response to indole-3-methanol
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0032993Cellular componentprotein-DNA complex
GO_0005856Cellular componentcytoskeleton
GO_0005576Cellular componentextracellular region
GO_0005915Cellular componentzonula adherens
GO_0005886Cellular componentplasma membrane
GO_0035580Cellular componentspecific granule lumen
GO_0030018Cellular componentZ disc
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0016342Cellular componentcatenin complex
GO_0005882Cellular componentintermediate filament
GO_0001533Cellular componentcornified envelope
GO_0005911Cellular componentcell-cell junction
GO_0005925Cellular componentfocal adhesion
GO_0030056Cellular componenthemidesmosome
GO_0071665Cellular componentgamma-catenin-TCF7L2 complex
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0030057Cellular componentdesmosome
GO_0014704Cellular componentintercalated disc
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0016922Molecular functionnuclear receptor binding
GO_0045294Molecular functionalpha-catenin binding
GO_0086083Molecular functioncell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
GO_0106006Molecular functioncytoskeletal protein-membrane anchor activity
GO_0019903Molecular functionprotein phosphatase binding
GO_0045296Molecular functioncadherin binding
GO_0005198Molecular functionstructural molecule activity
GO_0050839Molecular functioncell adhesion molecule binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameJUP
Protein nameAlternative protein JUP
Junction plakoglobin
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
SynonymsDP3
CTNNG
DescriptionFUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). .

FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. .

FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. .

FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. .

FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. .

FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. .

FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. .

AccessionsENST00000420370.5
C9JTX4
ENST00000424457.5
A0A0S2Z495
P14923
L8EAA6
C9J826
C9JKY1
C9JPI2
K7ERP3
ENST00000437369.5
ENST00000591690.5
A0A0S2Z487
ENST00000393931.8
ENST00000310706.9
ENST00000449889.5
ENST00000437187.5
ENST00000393930.5
C9JK18