ZEB2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	50 studies	54% ± 20%	Explore
fibroblast	42 studies	42% ± 18%	Explore
natural killer cell	38 studies	41% ± 17%	Explore
pericyte	37 studies	48% ± 19%	Explore
B cell	29 studies	30% ± 13%	Explore
mast cell	29 studies	52% ± 18%	Explore
classical monocyte	28 studies	61% ± 18%	Explore
smooth muscle cell	26 studies	41% ± 13%	Explore
conventional dendritic cell	25 studies	38% ± 18%	Explore
non-classical monocyte	25 studies	68% ± 16%	Explore
monocyte	24 studies	61% ± 18%	Explore
dendritic cell	21 studies	46% ± 16%	Explore
plasmacytoid dendritic cell	20 studies	41% ± 12%	Explore
endothelial cell	18 studies	35% ± 15%	Explore
astrocyte	18 studies	38% ± 15%	Explore
CD8-positive, alpha-beta T cell	17 studies	30% ± 10%	Explore
mature NK T cell	16 studies	36% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	53% ± 13%	Explore
oligodendrocyte	16 studies	80% ± 17%	Explore
oligodendrocyte precursor cell	16 studies	56% ± 16%	Explore
microglial cell	16 studies	64% ± 15%	Explore
naive B cell	15 studies	23% ± 4%	Explore
myeloid cell	15 studies	61% ± 19%	Explore
T cell	14 studies	23% ± 8%	Explore
connective tissue cell	13 studies	40% ± 17%	Explore
myofibroblast cell	13 studies	42% ± 21%	Explore
gamma-delta T cell	13 studies	33% ± 13%	Explore
memory B cell	12 studies	20% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	28% ± 9%	Explore
neutrophil	10 studies	39% ± 21%	Explore
glutamatergic neuron	10 studies	51% ± 23%	Explore
adipocyte	10 studies	58% ± 20%	Explore
leukocyte	9 studies	41% ± 15%	Explore
GABAergic neuron	9 studies	70% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	31% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	30% ± 11%	Explore
alveolar macrophage	8 studies	59% ± 21%	Explore
amacrine cell	8 studies	54% ± 18%	Explore
mononuclear phagocyte	7 studies	60% ± 15%	Explore
retina horizontal cell	7 studies	88% ± 7%	Explore
hematopoietic stem cell	7 studies	29% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	38% ± 7%	Explore
platelet	6 studies	26% ± 9%	Explore
neuron	6 studies	43% ± 12%	Explore
glial cell	6 studies	55% ± 13%	Explore
interneuron	6 studies	60% ± 26%	Explore
precursor B cell	6 studies	54% ± 20%	Explore
Mueller cell	6 studies	40% ± 21%	Explore
intermediate monocyte	6 studies	57% ± 20%	Explore
hematopoietic precursor cell	5 studies	40% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	37% ± 12%	Explore
progenitor cell	5 studies	40% ± 9%	Explore
retinal bipolar neuron	5 studies	32% ± 11%	Explore
pro-B cell	5 studies	41% ± 14%	Explore
immature B cell	5 studies	35% ± 11%	Explore
cardiac muscle cell	5 studies	30% ± 5%	Explore
melanocyte	5 studies	53% ± 23%	Explore
abnormal cell	4 studies	39% ± 19%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	66% ± 17%	Explore
lymphocyte	4 studies	35% ± 4%	Explore
Schwann cell	4 studies	56% ± 21%	Explore
retinal pigment epithelial cell	4 studies	47% ± 16%	Explore
inflammatory macrophage	4 studies	53% ± 14%	Explore
granulocyte	4 studies	43% ± 19%	Explore
plasmablast	3 studies	46% ± 30%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	29% ± 3%	Explore
hepatic stellate cell	3 studies	45% ± 20%	Explore
neural crest cell	3 studies	51% ± 8%	Explore
GABAergic interneuron	3 studies	60% ± 31%	Explore
common myeloid progenitor	3 studies	32% ± 13%	Explore
megakaryocyte	3 studies	51% ± 14%	Explore
innate lymphoid cell	3 studies	31% ± 9%	Explore
precursor cell	3 studies	49% ± 16%	Explore
retinal ganglion cell	3 studies	39% ± 11%	Explore
mesothelial cell	3 studies	27% ± 5%	Explore
tissue-resident macrophage	3 studies	71% ± 15%	Explore
GABAergic amacrine cell	3 studies	58% ± 7%	Explore
OFF-bipolar cell	3 studies	50% ± 18%	Explore
ON-bipolar cell	3 studies	52% ± 17%	Explore
glycinergic amacrine cell	3 studies	45% ± 12%	Explore
adventitial cell	3 studies	34% ± 10%	Explore
double negative thymocyte	3 studies	33% ± 21%	Explore
erythrocyte	3 studies	31% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	54% ± 20%	Explore
peripheral blood	17 studies	35% ± 13%	Explore
lung	15 studies	30% ± 14%	Explore
eye	6 studies	33% ± 16%	Explore
intestine	5 studies	33% ± 13%	Explore
heart	5 studies	36% ± 6%	Explore
adipose	5 studies	44% ± 23%	Explore
kidney	4 studies	22% ± 5%	Explore
bone marrow	4 studies	37% ± 20%	Explore
liver	4 studies	23% ± 8%	Explore
uterus	3 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	97%	11913.30	2563 / 2642	100%	28.14	702 / 705
skin	87%	3829.87	1577 / 1809	99%	21.28	469 / 472
breast	100%	7822.02	457 / 459	86%	5.37	961 / 1118
lung	100%	9246.74	577 / 578	83%	5.31	956 / 1155
adrenal gland	100%	7941.07	258 / 258	78%	4.62	179 / 230
kidney	76%	2644.75	68 / 89	88%	10.31	789 / 901
thymus	97%	3693.36	636 / 653	60%	2.35	366 / 605
prostate	92%	4073.82	225 / 245	61%	2.64	305 / 502
esophagus	84%	3424.23	1215 / 1445	67%	3.13	123 / 183
intestine	94%	4448.74	909 / 966	50%	2.56	263 / 527
bladder	100%	6506.05	21 / 21	43%	2.45	218 / 504
uterus	99%	5221.85	168 / 170	44%	2.69	201 / 459
ovary	100%	8764.50	180 / 180	43%	1.66	183 / 430
stomach	67%	2260.85	241 / 359	66%	4.30	189 / 286
adipose	100%	11973.79	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10067.96	1335 / 1335	0%	0	0 / 0
spleen	100%	8294.92	241 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	96%	13.08	77 / 80
heart	93%	4713.43	803 / 861	0%	0	0 / 0
pancreas	6%	132.84	20 / 328	86%	5.56	153 / 178
lymph node	0%	0	0 / 0	86%	8.16	25 / 29
peripheral blood	75%	4371.95	699 / 929	0%	0	0 / 0
muscle	61%	1420.98	488 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	56%	2.34	25 / 45
liver	18%	367.68	40 / 226	22%	0.88	90 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0097324	Biological process	melanocyte migration
GO_0030511	Biological process	positive regulation of transforming growth factor beta receptor signaling pathway
GO_0072537	Biological process	fibroblast activation
GO_0045636	Biological process	positive regulation of melanocyte differentiation
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0048143	Biological process	astrocyte activation
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0070269	Biological process	pyroptotic inflammatory response
GO_1904330	Biological process	positive regulation of myofibroblast contraction
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0010764	Biological process	negative regulation of fibroblast migration
GO_1905603	Biological process	regulation of blood-brain barrier permeability
GO_0036446	Biological process	myofibroblast differentiation
GO_0048066	Biological process	developmental pigmentation
GO_0043542	Biological process	endothelial cell migration
GO_0001935	Biological process	endothelial cell proliferation
GO_1903056	Biological process	regulation of melanosome organization
GO_0048023	Biological process	positive regulation of melanin biosynthetic process
GO_0043149	Biological process	stress fiber assembly
GO_0090649	Biological process	response to oxygen-glucose deprivation
GO_0048856	Biological process	anatomical structure development
GO_0007399	Biological process	nervous system development
GO_1904520	Biological process	regulation of myofibroblast cell apoptotic process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001227	Molecular function	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding
GO_0019208	Molecular function	phosphatase regulator activity

IV. Literature review

[source]

Gene name	ZEB2
Protein name	Zinc finger E-box binding homeobox 2 Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)
Synonyms	ZFHX1B KIAA0569 HRIHFB2411 SIP1 ZFX1B
Description	FUNCTION: Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters . Represses transcription of E-cadherin . Represses expression of MEOX2 . .
Accessions	A0A1X7SC99 A0A0D9SGG5 U3KQ33 ENST00000638087.1 E7ESP8 A0A6Q8PH34 A0A8I5KV18 ENST00000638007.1 ENST00000629520.2 ENST00000647488.1 ENST00000630572.2 E7EUW9 A0A0D9SF74 A0A1W2PS25 U3KPV5 ENST00000465070.5 A0A1B0GWA7 ENST00000434448.5 O60315 E7EVG9 A0A1B0GUM8 ENST00000539609.7 [O60315-2] ENST00000470879.5 ENST00000636732.2 A0A1B0GVV8 C9JUQ1 ENST00000627532.3 [O60315-1] ENST00000419938.5 ENST00000636445.1 ENST00000689298.1 A0A0D9SG93 ENST00000637045.1 H7C0G0 ENST00000409487.7 [O60315-1] ENST00000637873.1 ENST00000427902.5 ENST00000638128.1 ENST00000465308.5 ENST00000636413.1 U3KQ51 A0A0D9SF71 C9JU62 ENST00000639389.1 U3KPX6 ENST00000303660.8 A0A1B0GW50 A0A1B0GV02 ENST00000675069.1 ENST00000558170.6 [O60315-1] ENST00000636026.2 A0A1B0GTH3 ENST00000435831.5 ENST00000431672.4 A0JP08 ENST00000440875.6 ENST00000462355.2 A0A2R8YDQ8 ENST00000637267.2 ENST00000484313.3 ENST00000444559.5 ENST00000636471.1 ENST00000409211.5 ENST00000392861.6 ENST00000637304.1

ZEB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review