LRRK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050732Biological processnegative regulation of peptidyl-tyrosine phosphorylation
GO_0035556Biological processintracellular signal transduction
GO_0006468Biological processprotein phosphorylation
GO_1902533Biological processpositive regulation of intracellular signal transduction
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0045453Biological processbone resorption
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0036035Biological processosteoclast development
GO_0005829Cellular componentcytosol
GO_0005739Cellular componentmitochondrion
GO_0005525Molecular functionGTP binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameLRRK1
Protein nameLeucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)
LRRK1 protein
Leucine rich repeat kinase 1
SynonymsKIAA1790
DescriptionFUNCTION: Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. .

AccessionsE9PMK9
ENST00000525284.5
E9PK39
ENST00000534045.5
A6H8V9
Q9BS11
ENST00000531270.5
ENST00000532029.6 [Q38SD2-2]
E9PLF8
ENST00000526457.3
Q38SD2
ENST00000388948.8 [Q38SD2-1]
H0YEW1