ASPM | OmnibusX

Name	Number of supported studies	Average coverage
liver	3 studies	26% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	97%	2158.00	1757 / 1809	80%	10.82	378 / 472
lung	68%	181.21	394 / 578	82%	10.01	952 / 1155
esophagus	43%	461.01	619 / 1445	99%	22.91	182 / 183
intestine	51%	269.18	494 / 966	90%	9.60	475 / 527
stomach	41%	178.91	147 / 359	91%	11.53	261 / 286
uterus	9%	19.48	15 / 170	95%	17.50	436 / 459
ovary	18%	50.11	33 / 180	83%	6.49	357 / 430
tonsil	0%	0	0 / 0	100%	22.73	45 / 45
ureter	0%	0	0 / 0	100%	3.18	1 / 1
breast	15%	29.43	70 / 459	84%	11.58	939 / 1118
spleen	98%	599.68	236 / 241	0%	0	0 / 0
bladder	10%	20.76	2 / 21	83%	9.85	420 / 504
lymph node	0%	0	0 / 0	90%	13.02	26 / 29
liver	28%	95.77	64 / 226	57%	5.47	232 / 406
pancreas	5%	8.54	15 / 328	58%	4.23	104 / 178
adrenal gland	38%	70.14	98 / 258	14%	1.16	33 / 230
peripheral blood	38%	1574.66	355 / 929	0%	0	0 / 0
brain	6%	8.02	158 / 2642	32%	2.88	226 / 705
adipose	27%	57.93	323 / 1204	0%	0	0 / 0
kidney	12%	34.94	11 / 89	14%	0.94	126 / 901
thymus	11%	22.37	73 / 653	14%	2.62	82 / 605
prostate	13%	23.30	32 / 245	7%	0.39	34 / 502
blood vessel	12%	20.12	157 / 1335	0%	0	0 / 0
heart	10%	17.00	88 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	4%	0.13	3 / 80
muscle	2%	1.88	13 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0002052	Biological process	positive regulation of neuroblast proliferation
GO_0007283	Biological process	spermatogenesis
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_0051445	Biological process	regulation of meiotic cell cycle
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0008356	Biological process	asymmetric cell division
GO_0001764	Biological process	neuron migration
GO_0051661	Biological process	maintenance of centrosome location
GO_0021873	Biological process	forebrain neuroblast division
GO_0045665	Biological process	negative regulation of neuron differentiation
GO_0051653	Biological process	spindle localization
GO_0045769	Biological process	negative regulation of asymmetric cell division
GO_0008584	Biological process	male gonad development
GO_0090306	Biological process	meiotic spindle assembly
GO_0048589	Biological process	developmental growth
GO_0021987	Biological process	cerebral cortex development
GO_0048477	Biological process	oogenesis
GO_0007051	Biological process	spindle organization
GO_0016324	Cellular component	apical plasma membrane
GO_0097431	Cellular component	mitotic spindle pole
GO_0030496	Cellular component	midbody
GO_0005813	Cellular component	centrosome
GO_0036449	Cellular component	microtubule minus-end
GO_0005737	Cellular component	cytoplasm
GO_0072687	Cellular component	meiotic spindle
GO_0005634	Cellular component	nucleus
GO_0005516	Molecular function	calmodulin binding

Gene name	ASPM
Protein name	Abnormal spindle-like microcephaly associated splice variant 3 Abnormal spindle-like microcephaly associated splice variant 2 Abnormal spindle-like microcephaly-associated protein (Abnormal spindle protein homolog) (Asp homolog) Assembly factor for spindle microtubules
Synonyms	MCPH5
Description	FUNCTION: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex . May have a preferential role in regulating neurogenesis. .
Accessions	A0A7P0Z491 Q4G1H2 Q4G1H0 ENST00000680710.1 A0A7P0T8U9 ENST00000294732.11 [Q8IZT6-2] Q8IZT6 A0A7P0Z4R7 ENST00000680265.1 ENST00000681879.1 ENST00000367409.9 [Q8IZT6-1]

ASPM report