CCAR2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCAR2 at tissue level.

III. Associated gene sets

GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006397Biological processmRNA processing
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_0006974Biological processDNA damage response
GO_0009411Biological processresponse to UV
GO_0032784Biological processregulation of DNA-templated transcription elongation
GO_0042752Biological processregulation of circadian rhythm
GO_0043086Biological processnegative regulation of catalytic activity
GO_0031647Biological processregulation of protein stability
GO_0043653Biological processmitochondrial fragmentation involved in apoptotic process
GO_0090311Biological processregulation of protein deacetylation
GO_2000003Biological processpositive regulation of DNA damage checkpoint
GO_0008380Biological processRNA splicing
GO_1902230Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO_0016055Biological processWnt signaling pathway
GO_0043065Biological processpositive regulation of apoptotic process
GO_0048511Biological processrhythmic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030308Biological processnegative regulation of cell growth
GO_0044609Cellular componentDBIRD complex
GO_0005654Cellular componentnucleoplasm
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005819Cellular componentspindle
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0004857Molecular functionenzyme inhibitor activity
GO_0000774Molecular functionadenyl-nucleotide exchange factor activity
GO_0051082Molecular functionunfolded protein binding
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCAR2
Protein nameCell cycle and apoptosis regulator 2 (KIAA1967, isoform CRA_b)
Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2) (DBIRD complex subunit KIAA1967) (Deleted in breast cancer gene 1 protein) (DBC-1) (DBC.1) (NET35) (p30 DBC)
Cell cycle and apoptosis regulator 2
SynonymsKIAA1967
DBC1
hCG_2043023
DescriptionFUNCTION: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions . Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis . Inhibits SUV39H1 methyltransferase activity . Mediates ligand-dependent transcriptional activation by nuclear hormone receptors . Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress . Regulates the circadian expression of the core clock components NR1D1 and BMAL1 . Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation . Represses the ligand-dependent transcriptional activation function of ESR2 . Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 . Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization . Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway . Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 . Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 . Represses the transcriptional activator activity of BRCA1 . Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro . .

AccessionsE5RFJ3
ENST00000521837.5
H0YB24
ENST00000308511.9 [Q8N163-1]
ENST00000521301.5
E5RHH8
ENST00000520861.5
ENST00000520738.5
ENST00000389279.7 [Q8N163-1]
E5RHJ4
H0YC58
H0YC69
ENST00000522599.5
E5RGU7
Q8N163
G3V119
ENST00000523349.5
ENST00000518989.1
ENST00000523801.5