Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 11 studies | 30% ± 13% | |
glutamatergic neuron | 10 studies | 52% ± 24% | |
epithelial cell | 7 studies | 29% ± 24% | |
GABAergic neuron | 7 studies | 53% ± 21% | |
interneuron | 6 studies | 50% ± 21% | |
retinal ganglion cell | 6 studies | 41% ± 16% | |
retinal cone cell | 6 studies | 38% ± 19% | |
neuron | 5 studies | 39% ± 17% | |
cardiac muscle cell | 5 studies | 47% ± 12% | |
retinal rod cell | 5 studies | 43% ± 21% | |
goblet cell | 5 studies | 42% ± 27% | |
granule cell | 4 studies | 30% ± 10% | |
Mueller cell | 4 studies | 45% ± 18% | |
respiratory goblet cell | 4 studies | 39% ± 24% | |
endothelial cell | 3 studies | 46% ± 13% | |
GABAergic interneuron | 3 studies | 38% ± 9% | |
OFF-bipolar cell | 3 studies | 35% ± 16% | |
amacrine cell | 3 studies | 45% ± 30% | |
retinal pigment epithelial cell | 3 studies | 35% ± 26% | |
ependymal cell | 3 studies | 37% ± 15% | |
brush cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 99% | 5860.83 | 242 / 245 | 98% | 31.73 | 490 / 502 |
intestine | 98% | 9232.84 | 951 / 966 | 92% | 26.61 | 483 / 527 |
stomach | 98% | 3492.45 | 351 / 359 | 85% | 24.82 | 243 / 286 |
pancreas | 100% | 6204.47 | 328 / 328 | 62% | 8.07 | 111 / 178 |
brain | 92% | 5552.49 | 2438 / 2642 | 68% | 10.71 | 482 / 705 |
esophagus | 68% | 4865.87 | 977 / 1445 | 84% | 22.87 | 153 / 183 |
uterus | 61% | 1804.67 | 104 / 170 | 55% | 7.06 | 254 / 459 |
bladder | 57% | 1314.00 | 12 / 21 | 57% | 11.02 | 285 / 504 |
breast | 47% | 1503.48 | 215 / 459 | 65% | 7.58 | 726 / 1118 |
ureter | 0% | 0 | 0 / 0 | 100% | 15.24 | 1 / 1 |
muscle | 100% | 6374.80 | 802 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 98% | 15.95 | 78 / 80 |
heart | 97% | 13460.60 | 831 / 861 | 0% | 0 | 0 / 0 |
skin | 71% | 3053.18 | 1289 / 1809 | 20% | 1.90 | 94 / 472 |
adrenal gland | 27% | 377.47 | 69 / 258 | 62% | 7.41 | 143 / 230 |
ovary | 4% | 69.61 | 7 / 180 | 67% | 9.77 | 288 / 430 |
tonsil | 0% | 0 | 0 / 0 | 69% | 19.15 | 31 / 45 |
lung | 4% | 78.91 | 23 / 578 | 55% | 9.72 | 632 / 1155 |
spleen | 39% | 585.91 | 93 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 30% | 850.10 | 402 / 1335 | 0% | 0 | 0 / 0 |
thymus | 10% | 127.17 | 64 / 653 | 16% | 6.37 | 97 / 605 |
liver | 0% | 6.21 | 1 / 226 | 24% | 7.41 | 99 / 406 |
lymph node | 0% | 0 | 0 / 0 | 21% | 1.74 | 6 / 29 |
adipose | 10% | 220.08 | 122 / 1204 | 0% | 0 | 0 / 0 |
kidney | 0% | 0 | 0 / 89 | 9% | 1.40 | 78 / 901 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070373 | Biological process | negative regulation of ERK1 and ERK2 cascade |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0050801 | Biological process | monoatomic ion homeostasis |
GO_0006468 | Biological process | protein phosphorylation |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
GO_2000651 | Biological process | positive regulation of sodium ion transmembrane transporter activity |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005524 | Molecular function | ATP binding |
Gene name | WNK2 |
Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) WNK lysine deficient protein kinase 2 Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43) |
Synonyms | SDCCAG43 P/OKcl.13 KIAA1760 PRKWNK2 |
Description | FUNCTION: Serine/threonine-protein kinase component of the WNK2-SPAK/OSR1 kinase cascade, which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation . The WNK2-SPAK/OSR1 kinase cascade is composed of WNK2, which mediates phosphorylation and activation of downstream kinases OXSR1/OSR1 and STK39/SPAK (By similarity). Following activation, OXSR1/OSR1 and STK39/SPAK catalyze phosphorylation of ion cotransporters, regulating their activity (By similarity). Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively . Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5 . Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression . Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1 . WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity . . |
Accessions | E9PCD1 ENST00000432730 ENST00000453718.2 ENST00000411624.5 ENST00000297954.9 [Q9Y3S1-1] ENST00000432730.6 [Q9Y3S1-2] A6PVV2 H0Y7J9 ENST00000448039.6 ENST00000395477.6 ENST00000427277.7 H0Y7R3 H0Y7T5 Q9Y3S1 |