TNKS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_1904355Biological processpositive regulation of telomere capping
GO_0000209Biological processprotein polyubiquitination
GO_0051028Biological processmRNA transport
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_1904908Biological processnegative regulation of maintenance of mitotic sister chromatid cohesion, telomeric
GO_0007052Biological processmitotic spindle organization
GO_0018107Biological processpeptidyl-threonine phosphorylation
GO_0051301Biological processcell division
GO_1904357Biological processnegative regulation of telomere maintenance via telomere lengthening
GO_0032210Biological processregulation of telomere maintenance via telomerase
GO_0070198Biological processprotein localization to chromosome, telomeric region
GO_0070212Biological processprotein poly-ADP-ribosylation
GO_0051225Biological processspindle assembly
GO_0051973Biological processpositive regulation of telomerase activity
GO_1904743Biological processnegative regulation of telomeric DNA binding
GO_0015031Biological processprotein transport
GO_0016055Biological processWnt signaling pathway
GO_0070213Biological processprotein auto-ADP-ribosylation
GO_0032212Biological processpositive regulation of telomere maintenance via telomerase
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0097431Cellular componentmitotic spindle pole
GO_0005643Cellular componentnuclear pore
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000242Cellular componentpericentriolar material
GO_0000781Cellular componentchromosome, telomeric region
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0003950Molecular functionNAD+ ADP-ribosyltransferase activity
GO_0042393Molecular functionhistone binding
GO_0008270Molecular functionzinc ion binding
GO_1990404Molecular functionNAD+-protein ADP-ribosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTNKS
Protein nameTankyrase
Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1)
Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.-)
SynonymsTINF1
PARPL
PARP5A
TNKS1
TIN1
DescriptionFUNCTION: Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking . Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation . Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination . Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length . Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI . May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles . May be involved in spindle pole assembly through PARsylation of NUMA1 . Stimulates 26S proteasome activity . .

AccessionsENST00000646522.2 [O95271-1]
ENST00000518635.2
ENST00000517770.2
A0AA34QVM1
O95271
ENST00000520408.5
E7EWY6
E7EQ52
ENST00000310430.11 [O95271-1]
ENST00000519930.2
A0A0C4DGE3
ENST00000518281.5
E5RHD2
H0YAW5
ENST00000522110.1