I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 30% ± 8% | |
| goblet cell | 4 studies | 25% ± 5% | |
| glutamatergic neuron | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 30% ± 8% | |
| goblet cell | 4 studies | 25% ± 5% | |
| glutamatergic neuron | 3 studies | 21% ± 4% |
Insufficient scRNA-seq data for expression of TRPM4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 9641.57 | 245 / 245 | 100% | 287.23 | 502 / 502 |
| intestine | 100% | 8389.89 | 965 / 966 | 98% | 53.88 | 518 / 527 |
| esophagus | 100% | 3042.17 | 1445 / 1445 | 98% | 34.04 | 179 / 183 |
| stomach | 100% | 4215.04 | 359 / 359 | 97% | 43.24 | 278 / 286 |
| breast | 100% | 4090.68 | 458 / 459 | 96% | 36.57 | 1073 / 1118 |
| bladder | 100% | 3509.57 | 21 / 21 | 96% | 39.49 | 482 / 504 |
| lung | 100% | 4413.40 | 577 / 578 | 93% | 26.22 | 1072 / 1155 |
| uterus | 99% | 2240.13 | 169 / 170 | 91% | 28.69 | 416 / 459 |
| thymus | 100% | 4931.59 | 653 / 653 | 89% | 16.49 | 541 / 605 |
| kidney | 100% | 5918.42 | 89 / 89 | 86% | 17.38 | 772 / 901 |
| pancreas | 91% | 1285.14 | 299 / 328 | 93% | 41.33 | 165 / 178 |
| skin | 100% | 5603.39 | 1809 / 1809 | 63% | 10.62 | 296 / 472 |
| adrenal gland | 97% | 1510.16 | 250 / 258 | 46% | 5.57 | 105 / 230 |
| liver | 78% | 1020.96 | 177 / 226 | 44% | 7.63 | 178 / 406 |
| ovary | 36% | 445.21 | 65 / 180 | 80% | 16.83 | 342 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 28.16 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 44.81 | 1 / 1 |
| blood vessel | 100% | 4030.55 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| heart | 100% | 3663.26 | 858 / 861 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2942.12 | 1199 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 98% | 2352.12 | 788 / 803 | 0% | 0 | 0 / 0 |
| spleen | 96% | 1537.86 | 231 / 241 | 0% | 0 | 0 / 0 |
| brain | 68% | 751.32 | 1784 / 2642 | 20% | 2.41 | 143 / 705 |
| eye | 0% | 0 | 0 / 0 | 60% | 9.39 | 48 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 45% | 18.85 | 13 / 29 |
| peripheral blood | 1% | 6.07 | 5 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002407 | Biological process | dendritic cell chemotaxis |
| GO_1904179 | Biological process | positive regulation of adipose tissue development |
| GO_0016925 | Biological process | protein sumoylation |
| GO_0086047 | Biological process | membrane depolarization during Purkinje myocyte cell action potential |
| GO_0019722 | Biological process | calcium-mediated signaling |
| GO_0090263 | Biological process | positive regulation of canonical Wnt signaling pathway |
| GO_1904199 | Biological process | positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization |
| GO_1903949 | Biological process | positive regulation of atrial cardiac muscle cell action potential |
| GO_0045907 | Biological process | positive regulation of vasoconstriction |
| GO_0098662 | Biological process | inorganic cation transmembrane transport |
| GO_0071318 | Biological process | cellular response to ATP |
| GO_0035774 | Biological process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| GO_0002250 | Biological process | adaptive immune response |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0030502 | Biological process | negative regulation of bone mineralization |
| GO_0045600 | Biological process | positive regulation of fat cell differentiation |
| GO_0045668 | Biological process | negative regulation of osteoblast differentiation |
| GO_0086045 | Biological process | membrane depolarization during AV node cell action potential |
| GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
| GO_0098719 | Biological process | sodium ion import across plasma membrane |
| GO_0002724 | Biological process | regulation of T cell cytokine production |
| GO_0086048 | Biological process | membrane depolarization during bundle of His cell action potential |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0098911 | Biological process | regulation of ventricular cardiac muscle cell action potential |
| GO_0010460 | Biological process | positive regulation of heart rate |
| GO_0070588 | Biological process | calcium ion transmembrane transport |
| GO_0051289 | Biological process | protein homotetramerization |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0034706 | Cellular component | sodium channel complex |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005272 | Molecular function | sodium channel activity |
| GO_0099604 | Molecular function | ligand-gated calcium channel activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0005227 | Molecular function | calcium-activated cation channel activity |
| Gene name | TRPM4 |
| Protein name | Transient receptor potential cation channel subfamily M member 4 Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4) |
| Synonyms | LTRPC4 |
| Description | FUNCTION: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization . While it is activated by increase in intracellular Ca(2+), it is impermeable to it . Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation . . |
| Accessions | ENST00000595519.5 Q8TD43 M0R3H6 ENST00000598691.5 M0R0H1 ENST00000427978.6 [Q8TD43-3] ENST00000252826.10 [Q8TD43-1] ENST00000598697.5 ENST00000598502.5 M0QX92 A0A087X0Z3 M0QYK7 ENST00000597316.1 ENST00000599628.5 M0QZ19 |
