LGR6 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	3 studies	31% ± 11%	Explore
smooth muscle cell	3 studies	17% ± 1%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of LGR6 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	98%	1015.27	640 / 653	69%	8.58	418 / 605
ovary	39%	275.15	71 / 180	91%	51.17	391 / 430
lung	83%	606.37	479 / 578	43%	6.43	501 / 1155
prostate	87%	1132.03	212 / 245	27%	2.24	134 / 502
breast	65%	955.22	297 / 459	41%	8.56	463 / 1118
bladder	67%	504.43	14 / 21	39%	7.28	198 / 504
intestine	33%	126.43	318 / 966	71%	17.92	372 / 527
spleen	100%	1240.44	240 / 241	0%	0	0 / 0
esophagus	45%	485.76	657 / 1445	54%	18.15	98 / 183
blood vessel	95%	6986.29	1273 / 1335	0%	0	0 / 0
uterus	38%	274.61	65 / 170	34%	5.48	155 / 459
pancreas	0%	0.80	1 / 328	67%	9.85	119 / 178
stomach	8%	42.45	27 / 359	59%	12.90	170 / 286
skin	61%	486.30	1109 / 1809	2%	0.28	10 / 472
brain	32%	283.17	847 / 2642	28%	8.01	195 / 705
heart	58%	992.07	496 / 861	0%	0	0 / 0
liver	28%	116.24	63 / 226	20%	2.49	81 / 406
peripheral blood	43%	562.24	401 / 929	0%	0	0 / 0
adipose	27%	116.89	326 / 1204	0%	0	0 / 0
kidney	21%	92.04	19 / 89	2%	0.13	16 / 901
tonsil	0%	0	0 / 0	20%	1.26	9 / 45
lymph node	0%	0	0 / 0	14%	0.69	4 / 29
adrenal gland	1%	3.28	3 / 258	2%	0.22	4 / 230
eye	0%	0	0 / 0	1%	0.05	1 / 80
muscle	1%	5.37	9 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_1990523	Biological process	bone regeneration
GO_0007186	Biological process	G protein-coupled receptor signaling pathway
GO_0016055	Biological process	Wnt signaling pathway
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0008283	Biological process	cell population proliferation
GO_0030335	Biological process	positive regulation of cell migration
GO_0007411	Biological process	axon guidance
GO_0050919	Biological process	negative chemotaxis
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0031982	Cellular component	vesicle
GO_0005886	Cellular component	plasma membrane
GO_0004888	Molecular function	transmembrane signaling receptor activity
GO_0016500	Molecular function	protein-hormone receptor activity
GO_0008201	Molecular function	heparin binding
GO_0048495	Molecular function	Roundabout binding
GO_0004930	Molecular function	G protein-coupled receptor activity
GO_0005515	Molecular function	protein binding

Gene name	LGR6
Protein name	Leucine-rich repeat-containing G-protein coupled receptor 6 Leucine rich repeat containing G protein-coupled receptor 6
Synonyms	UNQ6427/PRO21331 VTS20631
Description	FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. .
Accessions	ENST00000439764.2 [Q9HBX8-1] Q5T508 D6R9F0 ENST00000367278.8 [Q9HBX8-3] ENST00000487787.5 ENST00000423542.5 Q9HBX8 ENST00000255432.11 [Q9HBX8-2]

LGR6 report