UBE2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0007288Biological processsperm axoneme assembly
GO_0016567Biological processprotein ubiquitination
GO_0010845Biological processpositive regulation of reciprocal meiotic recombination
GO_0006281Biological processDNA repair
GO_0007283Biological processspermatogenesis
GO_0070979Biological processprotein K11-linked ubiquitination
GO_0000209Biological processprotein polyubiquitination
GO_0051093Biological processnegative regulation of developmental process
GO_0001701Biological processin utero embryonic development
GO_0070193Biological processsynaptonemal complex organization
GO_0090263Biological processpositive regulation of canonical Wnt signaling pathway
GO_1901874Biological processnegative regulation of post-translational protein modification
GO_0006974Biological processDNA damage response
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0051026Biological processchiasma assembly
GO_0051865Biological processprotein autoubiquitination
GO_0009411Biological processresponse to UV
GO_0006301Biological processpostreplication repair
GO_0045141Biological processmeiotic telomere clustering
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050821Biological processprotein stabilization
GO_0070534Biological processprotein K63-linked ubiquitination
GO_2000242Biological processnegative regulation of reproductive process
GO_0006915Biological processapoptotic process
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0043951Biological processnegative regulation of cAMP-mediated signaling
GO_0035234Biological processectopic germ cell programmed cell death
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0033503Cellular componentHULC complex
GO_0005886Cellular componentplasma membrane
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0001741Cellular componentXY body
GO_0005634Cellular componentnucleus
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005524Molecular functionATP binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0061631Molecular functionubiquitin conjugating enzyme activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBE2B
Protein nameUbiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (Ubiquitin carrier protein B) (Ubiquitin-protein ligase B)
Ubiquitin conjugating enzyme E2 B
Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B)
SynonymsRAD6B
UBCH1
DescriptionFUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth. May play a role in DNA repair . .

AccessionsENST00000506787.5
P63146
ENST00000265339.7
H0YA80
D6RDW8
ENST00000510021.5
H0Y9V2
ENST00000507277.2