RSPO2 | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	35% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	86%	667.13	211 / 245	69%	3.06	346 / 502
brain	69%	566.99	1824 / 2642	64%	4.42	450 / 705
lung	98%	618.06	567 / 578	20%	0.87	232 / 1155
intestine	94%	995.40	904 / 966	14%	0.67	74 / 527
stomach	85%	896.42	306 / 359	20%	0.95	58 / 286
esophagus	74%	702.37	1064 / 1445	14%	0.33	25 / 183
bladder	52%	199.24	11 / 21	11%	0.38	56 / 504
blood vessel	32%	76.02	433 / 1335	0%	0	0 / 0
adrenal gland	0%	0	0 / 258	22%	2.23	50 / 230
uterus	5%	34.52	9 / 170	10%	1.24	45 / 459
liver	1%	1.48	3 / 226	11%	0.55	46 / 406
ovary	10%	16.24	18 / 180	1%	0.07	3 / 430
pancreas	0%	0	0 / 328	10%	0.62	18 / 178
adipose	5%	7.77	58 / 1204	0%	0	0 / 0
heart	4%	5.21	31 / 861	0%	0	0 / 0
skin	0%	0.19	3 / 1809	2%	0.18	11 / 472
breast	0%	0.47	1 / 459	1%	0.03	15 / 1118
thymus	0%	0.13	1 / 653	1%	0.05	7 / 605
eye	0%	0	0 / 0	1%	0.02	1 / 80
kidney	0%	0	0 / 89	1%	0.03	8 / 901
muscle	0%	0.56	3 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0060437	Biological process	lung growth
GO_0060173	Biological process	limb development
GO_0035115	Biological process	embryonic forelimb morphogenesis
GO_0035116	Biological process	embryonic hindlimb morphogenesis
GO_0060441	Biological process	epithelial tube branching involved in lung morphogenesis
GO_0060535	Biological process	trachea cartilage morphogenesis
GO_0090263	Biological process	positive regulation of canonical Wnt signaling pathway
GO_0071542	Biological process	dopaminergic neuron differentiation
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0030282	Biological process	bone mineralization
GO_0042489	Biological process	negative regulation of odontogenesis of dentin-containing tooth
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0001649	Biological process	osteoblast differentiation
GO_0009986	Cellular component	cell surface
GO_0005576	Cellular component	extracellular region
GO_0008201	Molecular function	heparin binding
GO_0005102	Molecular function	signaling receptor binding
GO_0005515	Molecular function	protein binding

Gene name	RSPO2
Protein name	R-spondin 2 R-spondin-2 (Roof plate-specific spondin-2) (hRspo2)
Synonyms	UNQ9384/PRO34209
Description	FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway . During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form . .
Accessions	Q6UXX9 ENST00000517939.5 [Q6UXX9-2] E5RH25 E5RGU9 ENST00000521956.5 ENST00000276659.10 [Q6UXX9-1] ENST00000522333.1 ENST00000666252.1 A0A590UJ52 ENST00000517781.5 [Q6UXX9-3]

RSPO2 report