UBA52 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0019941Biological processmodification-dependent protein catabolic process
GO_0036211Biological processprotein modification process
GO_0002181Biological processcytoplasmic translation
GO_0005615Cellular componentextracellular space
GO_0022626Cellular componentcytosolic ribosome
GO_0005886Cellular componentplasma membrane
GO_0022627Cellular componentcytosolic small ribosomal subunit
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0022625Cellular componentcytosolic large ribosomal subunit
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0010008Cellular componentendosome membrane
GO_0031982Cellular componentvesicle
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0031386Molecular functionprotein tag activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0003735Molecular functionstructural constituent of ribosome
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBA52
Protein nameUbiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40)]
Ubiquitin A-52 residue ribosomal protein fusion product 1
Ubiquitin-ribosomal protein eL40 fusion protein (Ubiquitin A-52 residue ribosomal protein fusion product 1)
SynonymsUBCEP2
hCG_37048
DescriptionFUNCTION: [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. .; FUNCTION: [Large ribosomal subunit protein eL40]: Component of the 60S subunit of the ribosome . Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs . .

FUNCTION: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. .

FUNCTION: Component of the 60S subunit of the ribosome. .; FUNCTION: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. .

AccessionsENST00000594527.1
M0R1V7
P62987
M0R1M6
ENST00000596273.5
ENST00000430157.6
ENST00000595683.5
ENST00000597451.5
Q3MIH3
M0R2S1
ENST00000599256.5
ENST00000599551.5
ENST00000442744.7
ENST00000596272.5
ENST00000595158.5
ENST00000598780.5
ENST00000599595.5
ENST00000596304.5