MYO7A report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MYO7A at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MYO7A at tissue level.

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0007601Biological processvisual perception
GO_0007605Biological processsensory perception of sound
GO_0006897Biological processendocytosis
GO_0030048Biological processactin filament-based movement
GO_0050957Biological processequilibrioception
GO_0051904Biological processpigment granule transport
GO_0006886Biological processintracellular protein transport
GO_0060088Biological processauditory receptor cell stereocilium organization
GO_0042462Biological processeye photoreceptor cell development
GO_0042490Biological processmechanoreceptor differentiation
GO_0090102Biological processcochlea development
GO_0050953Biological processsensory perception of light stimulus
GO_0007015Biological processactin filament organization
GO_0001845Biological processphagolysosome assembly
GO_0008104Biological processprotein localization
GO_0007423Biological processsensory organ development
GO_0005902Cellular componentmicrovillus
GO_0016324Cellular componentapical plasma membrane
GO_0032420Cellular componentstereocilium
GO_0032391Cellular componentphotoreceptor connecting cilium
GO_0001750Cellular componentphotoreceptor outer segment
GO_0016020Cellular componentmembrane
GO_0001917Cellular componentphotoreceptor inner segment
GO_1990435Cellular componentupper tip-link density
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005938Cellular componentcell cortex
GO_0120044Cellular componentstereocilium base
GO_0005737Cellular componentcytoplasm
GO_0042470Cellular componentmelanosome
GO_0031477Cellular componentmyosin VII complex
GO_0005765Cellular componentlysosomal membrane
GO_0043531Molecular functionADP binding
GO_0019904Molecular functionprotein domain specific binding
GO_0030507Molecular functionspectrin binding
GO_0051015Molecular functionactin filament binding
GO_0042802Molecular functionidentical protein binding
GO_0000146Molecular functionmicrofilament motor activity
GO_0005524Molecular functionATP binding
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMYO7A
Protein nameMyosin VIIA
Unconventional myosin-VIIa
SynonymsUSH1B
DescriptionFUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. .

AccessionsA0A590UJG0
ENST00000458637.6 [Q13402-2]
A0A590UJR8
A0A590UJ94
ENST00000670577.1
ENST00000660626.1
ENST00000409709.9 [Q13402-1]
B9A012
ENST00000458169.2
ENST00000669443.1
Q13402
ENST00000409893.6
H7C4D8
ENST00000409619.6 [Q13402-8]