YWHAQ | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	42 studies	45% ± 17%	Explore
endothelial cell	41 studies	38% ± 17%	Explore
natural killer cell	37 studies	40% ± 14%	Explore
B cell	34 studies	33% ± 11%	Explore
pericyte	34 studies	49% ± 19%	Explore
CD8-positive, alpha-beta T cell	33 studies	38% ± 16%	Explore
CD4-positive, alpha-beta T cell	32 studies	37% ± 16%	Explore
macrophage	31 studies	25% ± 9%	Explore
smooth muscle cell	29 studies	48% ± 19%	Explore
T cell	28 studies	41% ± 17%	Explore
conventional dendritic cell	23 studies	34% ± 16%	Explore
epithelial cell	23 studies	46% ± 22%	Explore
regulatory T cell	23 studies	37% ± 10%	Explore
endothelial cell of lymphatic vessel	22 studies	41% ± 16%	Explore
basal cell	21 studies	47% ± 20%	Explore
memory B cell	19 studies	29% ± 8%	Explore
non-classical monocyte	19 studies	30% ± 14%	Explore
classical monocyte	19 studies	24% ± 11%	Explore
connective tissue cell	19 studies	52% ± 22%	Explore
dendritic cell	18 studies	35% ± 18%	Explore
gamma-delta T cell	18 studies	40% ± 17%	Explore
mature NK T cell	18 studies	41% ± 10%	Explore
naive B cell	18 studies	28% ± 7%	Explore
ciliated cell	17 studies	41% ± 18%	Explore
mast cell	16 studies	29% ± 7%	Explore
mucosal invariant T cell	15 studies	42% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	44% ± 11%	Explore
oligodendrocyte	15 studies	40% ± 15%	Explore
monocyte	14 studies	26% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	39% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	24% ± 6%	Explore
capillary endothelial cell	14 studies	34% ± 15%	Explore
myofibroblast cell	14 studies	54% ± 19%	Explore
plasmacytoid dendritic cell	13 studies	26% ± 9%	Explore
astrocyte	13 studies	29% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	37% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	39% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	34% ± 8%	Explore
vein endothelial cell	12 studies	36% ± 14%	Explore
endothelial cell of vascular tree	12 studies	42% ± 11%	Explore
plasma cell	11 studies	34% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	35% ± 9%	Explore
neuron	11 studies	55% ± 27%	Explore
endothelial cell of artery	11 studies	33% ± 12%	Explore
type I pneumocyte	10 studies	30% ± 13%	Explore
innate lymphoid cell	10 studies	41% ± 12%	Explore
plasmablast	10 studies	45% ± 23%	Explore
secretory cell	10 studies	38% ± 16%	Explore
glutamatergic neuron	10 studies	40% ± 22%	Explore
progenitor cell	10 studies	47% ± 20%	Explore
mesothelial cell	10 studies	48% ± 27%	Explore
oligodendrocyte precursor cell	10 studies	33% ± 16%	Explore
myeloid cell	10 studies	28% ± 11%	Explore
type II pneumocyte	9 studies	34% ± 14%	Explore
platelet	9 studies	27% ± 8%	Explore
leukocyte	9 studies	36% ± 9%	Explore
abnormal cell	9 studies	53% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	45% ± 20%	Explore
T follicular helper cell	8 studies	38% ± 11%	Explore
GABAergic neuron	8 studies	39% ± 16%	Explore
alveolar macrophage	7 studies	25% ± 6%	Explore
retina horizontal cell	7 studies	62% ± 24%	Explore
interneuron	7 studies	44% ± 23%	Explore
hematopoietic stem cell	7 studies	49% ± 9%	Explore
precursor B cell	7 studies	53% ± 14%	Explore
club cell	6 studies	35% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	47% ± 16%	Explore
mononuclear phagocyte	6 studies	30% ± 13%	Explore
epithelial cell of proximal tubule	6 studies	33% ± 13%	Explore
kidney loop of Henle epithelial cell	6 studies	35% ± 9%	Explore
renal alpha-intercalated cell	6 studies	49% ± 13%	Explore
goblet cell	6 studies	34% ± 14%	Explore
transit amplifying cell	6 studies	37% ± 14%	Explore
erythrocyte	6 studies	39% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	43% ± 13%	Explore
CD4-positive helper T cell	5 studies	29% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	43% ± 17%	Explore
hematopoietic precursor cell	5 studies	59% ± 20%	Explore
ionocyte	5 studies	41% ± 12%	Explore
enterocyte	5 studies	25% ± 9%	Explore
enteroendocrine cell	5 studies	52% ± 21%	Explore
intestinal crypt stem cell	5 studies	31% ± 9%	Explore
glial cell	5 studies	35% ± 26%	Explore
microglial cell	5 studies	26% ± 8%	Explore
OFF-bipolar cell	5 studies	41% ± 27%	Explore
ON-bipolar cell	5 studies	42% ± 27%	Explore
retinal ganglion cell	5 studies	71% ± 25%	Explore
retinal rod cell	5 studies	30% ± 16%	Explore
lymphocyte	5 studies	40% ± 16%	Explore
pro-B cell	5 studies	62% ± 9%	Explore
brush cell	5 studies	37% ± 21%	Explore
immature B cell	5 studies	44% ± 18%	Explore
amacrine cell	5 studies	50% ± 26%	Explore
cardiac muscle cell	5 studies	20% ± 4%	Explore
granulocyte	5 studies	36% ± 11%	Explore
deuterosomal cell	4 studies	24% ± 5%	Explore
precursor cell	4 studies	52% ± 23%	Explore
pancreatic A cell	4 studies	79% ± 13%	Explore
type B pancreatic cell	4 studies	78% ± 17%	Explore
exhausted T cell	4 studies	41% ± 8%	Explore
granule cell	4 studies	28% ± 13%	Explore
GABAergic amacrine cell	4 studies	34% ± 13%	Explore
glycinergic amacrine cell	4 studies	29% ± 12%	Explore
erythroblast	4 studies	60% ± 23%	Explore
megakaryocyte	4 studies	31% ± 13%	Explore
retinal cone cell	4 studies	43% ± 22%	Explore
adventitial cell	4 studies	46% ± 7%	Explore
acinar cell	4 studies	49% ± 27%	Explore
muscle cell	4 studies	36% ± 20%	Explore
germinal center B cell	4 studies	36% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	60% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	33% ± 12%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	58% ± 28%	Explore
group 3 innate lymphoid cell	4 studies	62% ± 7%	Explore
T-helper 17 cell	4 studies	49% ± 18%	Explore
T-helper 1 cell	4 studies	47% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	48% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	35% ± 15%	Explore
duct epithelial cell	3 studies	19% ± 0%	Explore
respiratory goblet cell	3 studies	34% ± 21%	Explore
pancreatic D cell	3 studies	76% ± 21%	Explore
glomerular endothelial cell	3 studies	28% ± 3%	Explore
podocyte	3 studies	63% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	61% ± 25%	Explore
neural crest cell	3 studies	67% ± 19%	Explore
retinal bipolar neuron	3 studies	59% ± 18%	Explore
extravillous trophoblast	3 studies	63% ± 14%	Explore
placental villous trophoblast	3 studies	41% ± 16%	Explore
neuroendocrine cell	3 studies	58% ± 22%	Explore
Schwann cell	3 studies	50% ± 23%	Explore
retinal pigment epithelial cell	3 studies	46% ± 17%	Explore
serous secreting cell	3 studies	31% ± 1%	Explore
intraepithelial lymphocyte	3 studies	36% ± 20%	Explore
Mueller cell	3 studies	42% ± 1%	Explore
rod bipolar cell	3 studies	46% ± 13%	Explore
chondrocyte	3 studies	43% ± 21%	Explore
myoepithelial cell	3 studies	61% ± 7%	Explore
pancreatic ductal cell	3 studies	82% ± 10%	Explore
neural progenitor cell	3 studies	25% ± 9%	Explore
hepatocyte	3 studies	50% ± 26%	Explore
melanocyte	3 studies	35% ± 8%	Explore
keratinocyte	3 studies	47% ± 9%	Explore
double negative thymocyte	3 studies	62% ± 14%	Explore
progenitor cell of mammary luminal epithelium	3 studies	54% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	39% ± 17%	Explore
brain	18 studies	33% ± 16%	Explore
peripheral blood	16 studies	37% ± 11%	Explore
intestine	11 studies	35% ± 19%	Explore
eye	11 studies	35% ± 14%	Explore
kidney	9 studies	34% ± 13%	Explore
lymph node	6 studies	37% ± 18%	Explore
pancreas	5 studies	64% ± 28%	Explore
bone marrow	5 studies	31% ± 10%	Explore
heart	5 studies	20% ± 6%	Explore
uterus	5 studies	45% ± 16%	Explore
liver	5 studies	42% ± 22%	Explore
placenta	4 studies	39% ± 16%	Explore
prostate	4 studies	41% ± 13%	Explore
breast	4 studies	49% ± 6%	Explore
adipose	4 studies	21% ± 7%	Explore
adrenal gland	3 studies	37% ± 13%	Explore
esophagus	3 studies	51% ± 29%	Explore
skin	3 studies	37% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	14794.77	1445 / 1445	100%	498.99	183 / 183
ovary	100%	13718.78	180 / 180	100%	456.92	430 / 430
stomach	100%	9699.05	359 / 359	100%	336.38	286 / 286
brain	100%	16844.74	2640 / 2642	100%	502.59	705 / 705
breast	100%	13039.01	459 / 459	100%	427.38	1116 / 1118
prostate	100%	11236.47	245 / 245	100%	441.03	501 / 502
uterus	100%	15692.20	170 / 170	100%	420.45	458 / 459
lung	100%	11815.20	576 / 578	100%	416.45	1155 / 1155
intestine	100%	13331.37	966 / 966	100%	334.00	525 / 527
pancreas	100%	9262.18	328 / 328	99%	247.41	177 / 178
bladder	100%	12692.05	21 / 21	99%	372.79	499 / 504
thymus	100%	10731.62	653 / 653	99%	245.39	598 / 605
skin	100%	14715.99	1809 / 1809	98%	301.89	461 / 472
kidney	100%	9392.37	89 / 89	96%	251.22	863 / 901
adrenal gland	100%	12246.21	258 / 258	94%	306.57	217 / 230
liver	89%	3882.81	202 / 226	84%	131.26	340 / 406
adipose	100%	13291.25	1204 / 1204	0%	0	0 / 0
blood vessel	100%	16769.22	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	233.70	29 / 29
spleen	100%	7065.32	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	379.79	45 / 45
ureter	0%	0	0 / 0	100%	99.05	1 / 1
heart	95%	7695.72	818 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	209.22	75 / 80
peripheral blood	74%	5748.56	685 / 929	0%	0	0 / 0
muscle	73%	2509.71	590 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0006605	Biological process	protein targeting
GO_0007264	Biological process	small GTPase-mediated signal transduction
GO_0034766	Biological process	negative regulation of monoatomic ion transmembrane transport
GO_0021762	Biological process	substantia nigra development
GO_0008104	Biological process	protein localization
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0019904	Molecular function	protein domain specific binding
GO_0071889	Molecular function	14-3-3 protein binding
GO_0042802	Molecular function	identical protein binding
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding

Gene name	YWHAQ
Protein name	Uncharacterized protein YWHAQ 14-3-3 protein theta (14-3-3 protein T-cell) (14-3-3 protein tau) (Protein HS1) Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Synonyms
Description	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. .
Accessions	Q53RR5 P27348 ENST00000446619.1 E9PG15 ENST00000238081.8 Q53S41 ENST00000381844.8

YWHAQ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review