Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| cardiac muscle cell | 6 studies | 61% ± 17% | |
| GABAergic neuron | 6 studies | 32% ± 10% | |
| glutamatergic neuron | 5 studies | 28% ± 9% | |
| GABAergic interneuron | 3 studies | 23% ± 8% | |
| interneuron | 3 studies | 44% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 4 studies | 27% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 95% | 2743.95 | 20 / 21 | 13% | 0.60 | 65 / 504 |
| heart | 94% | 3278.57 | 806 / 861 | 0% | 0 | 0 / 0 |
| intestine | 74% | 3944.64 | 716 / 966 | 10% | 0.52 | 53 / 527 |
| stomach | 45% | 1714.22 | 162 / 359 | 20% | 1.55 | 57 / 286 |
| esophagus | 55% | 846.04 | 789 / 1445 | 5% | 0.12 | 10 / 183 |
| lung | 42% | 228.61 | 244 / 578 | 5% | 0.46 | 56 / 1155 |
| brain | 19% | 79.67 | 512 / 2642 | 13% | 0.26 | 93 / 705 |
| uterus | 9% | 45.12 | 15 / 170 | 9% | 1.96 | 43 / 459 |
| prostate | 10% | 56.33 | 24 / 245 | 3% | 0.09 | 16 / 502 |
| pancreas | 0% | 0 | 0 / 328 | 6% | 0.41 | 11 / 178 |
| skin | 5% | 29.77 | 88 / 1809 | 0% | 0.01 | 2 / 472 |
| adrenal gland | 0% | 0.85 | 1 / 258 | 4% | 0.12 | 10 / 230 |
| liver | 3% | 8.00 | 6 / 226 | 1% | 0.01 | 3 / 406 |
| ovary | 0% | 0 | 0 / 180 | 1% | 0.14 | 6 / 430 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
| breast | 1% | 3.40 | 3 / 459 | 0% | 0.02 | 5 / 1118 |
| blood vessel | 1% | 9.68 | 12 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0.82 | 1 / 653 | 0% | 0.00 | 1 / 605 |
| adipose | 0% | 0.89 | 2 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0.00 | 1 / 901 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007197 | Biological process | adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway |
| GO_0007188 | Biological process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| GO_0007213 | Biological process | G protein-coupled acetylcholine receptor signaling pathway |
| GO_0007207 | Biological process | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway |
| GO_0009615 | Biological process | response to virus |
| GO_0006940 | Biological process | regulation of smooth muscle contraction |
| GO_0098664 | Biological process | G protein-coupled serotonin receptor signaling pathway |
| GO_0007186 | Biological process | G protein-coupled receptor signaling pathway |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
| GO_0007187 | Biological process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO_0008016 | Biological process | regulation of heart contraction |
| GO_0007399 | Biological process | nervous system development |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0043679 | Cellular component | axon terminus |
| GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0098981 | Cellular component | cholinergic synapse |
| GO_0032279 | Cellular component | asymmetric synapse |
| GO_0045202 | Cellular component | synapse |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0032280 | Cellular component | symmetric synapse |
| GO_1990763 | Molecular function | arrestin family protein binding |
| GO_0004993 | Molecular function | G protein-coupled serotonin receptor activity |
| GO_0016907 | Molecular function | G protein-coupled acetylcholine receptor activity |
| Gene name | CHRM2 |
| Protein name | Muscarinic acetylcholine receptor Muscarinic M2 receptor Muscarinic acetylcholine receptor M2 M2 muscarinic acetylcholine receptor |
| Synonyms | tcag7.414 hCG_1641225 |
| Description | FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. . FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. . FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. . |
| Accessions | ENST00000320658.9 ENST00000401861.1 Q96RH0 ENST00000680005.1 A4D1Q0 ENST00000453373.5 P08172 Q6SL59 Q6SL56 Q86SJ1 ENST00000445907.6 |
