DARS1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	24 studies	24% ± 10%	Explore
B cell	23 studies	22% ± 5%	Explore
endothelial cell	22 studies	27% ± 12%	Explore
CD4-positive, alpha-beta T cell	19 studies	23% ± 7%	Explore
pericyte	18 studies	27% ± 9%	Explore
macrophage	16 studies	28% ± 10%	Explore
CD8-positive, alpha-beta T cell	16 studies	24% ± 7%	Explore
naive B cell	15 studies	22% ± 5%	Explore
astrocyte	15 studies	31% ± 14%	Explore
smooth muscle cell	15 studies	21% ± 6%	Explore
memory B cell	15 studies	22% ± 5%	Explore
regulatory T cell	15 studies	25% ± 7%	Explore
T cell	14 studies	21% ± 6%	Explore
basal cell	11 studies	30% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	20% ± 5%	Explore
myofibroblast cell	10 studies	24% ± 6%	Explore
epithelial cell	10 studies	42% ± 20%	Explore
connective tissue cell	9 studies	24% ± 7%	Explore
natural killer cell	9 studies	22% ± 6%	Explore
gamma-delta T cell	9 studies	24% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	24% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	21% ± 2%	Explore
conventional dendritic cell	8 studies	27% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	25% ± 7%	Explore
abnormal cell	8 studies	32% ± 18%	Explore
mucosal invariant T cell	8 studies	20% ± 2%	Explore
plasmacytoid dendritic cell	8 studies	26% ± 8%	Explore
adipocyte	8 studies	22% ± 6%	Explore
ciliated cell	7 studies	28% ± 13%	Explore
microglial cell	7 studies	30% ± 12%	Explore
oligodendrocyte	7 studies	24% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	23% ± 8%	Explore
hematopoietic precursor cell	6 studies	31% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	20% ± 3%	Explore
progenitor cell	6 studies	21% ± 4%	Explore
myeloid cell	6 studies	25% ± 10%	Explore
club cell	6 studies	21% ± 5%	Explore
Mueller cell	6 studies	28% ± 7%	Explore
endothelial cell of vascular tree	6 studies	22% ± 8%	Explore
oligodendrocyte precursor cell	6 studies	26% ± 9%	Explore
goblet cell	6 studies	27% ± 15%	Explore
plasma cell	5 studies	31% ± 10%	Explore
neuron	5 studies	26% ± 11%	Explore
endothelial cell of artery	5 studies	20% ± 6%	Explore
erythroblast	5 studies	31% ± 10%	Explore
hematopoietic stem cell	5 studies	31% ± 9%	Explore
lymphocyte	5 studies	24% ± 9%	Explore
precursor B cell	5 studies	29% ± 8%	Explore
capillary endothelial cell	5 studies	20% ± 6%	Explore
retina horizontal cell	5 studies	21% ± 7%	Explore
retinal cone cell	5 studies	32% ± 11%	Explore
monocyte	5 studies	22% ± 5%	Explore
dendritic cell	5 studies	32% ± 16%	Explore
T follicular helper cell	5 studies	20% ± 3%	Explore
plasmablast	4 studies	43% ± 18%	Explore
classical monocyte	4 studies	22% ± 7%	Explore
retinal ganglion cell	4 studies	37% ± 19%	Explore
pro-B cell	4 studies	27% ± 2%	Explore
type II pneumocyte	4 studies	22% ± 6%	Explore
endothelial cell of lymphatic vessel	4 studies	23% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	29% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	27% ± 3%	Explore
innate lymphoid cell	4 studies	18% ± 2%	Explore
hepatocyte	4 studies	39% ± 26%	Explore
type I pneumocyte	4 studies	21% ± 7%	Explore
glutamatergic neuron	4 studies	45% ± 16%	Explore
mesothelial cell	4 studies	27% ± 15%	Explore
secretory cell	4 studies	22% ± 2%	Explore
kidney loop of Henle epithelial cell	3 studies	18% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	25% ± 4%	Explore
epithelial cell of proximal tubule	3 studies	29% ± 12%	Explore
neural crest cell	3 studies	22% ± 0%	Explore
extravillous trophoblast	3 studies	27% ± 5%	Explore
common myeloid progenitor	3 studies	36% ± 22%	Explore
immature B cell	3 studies	23% ± 3%	Explore
amacrine cell	3 studies	29% ± 8%	Explore
retinal bipolar neuron	3 studies	31% ± 11%	Explore
retinal rod cell	3 studies	22% ± 4%	Explore
cardiac muscle cell	3 studies	18% ± 3%	Explore
rod bipolar cell	3 studies	38% ± 8%	Explore
chondrocyte	3 studies	25% ± 4%	Explore
germinal center B cell	3 studies	26% ± 2%	Explore
exhausted T cell	3 studies	30% ± 3%	Explore
muscle cell	3 studies	34% ± 14%	Explore
GABAergic neuron	3 studies	46% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	27% ± 3%	Explore
granulocyte monocyte progenitor cell	3 studies	30% ± 5%	Explore
mast cell	3 studies	21% ± 5%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	52% ± 20%	Explore
intestinal crypt stem cell	3 studies	24% ± 5%	Explore
leukocyte	3 studies	22% ± 4%	Explore
alveolar macrophage	3 studies	20% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 10%	Explore
transit amplifying cell	3 studies	38% ± 23%	Explore
interneuron	3 studies	40% ± 19%	Explore
double negative thymocyte	3 studies	32% ± 19%	Explore
mature NK T cell	3 studies	20% ± 1%	Explore
enteroendocrine cell	3 studies	26% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	21% ± 6%	Explore
lung	9 studies	24% ± 5%	Explore
brain	7 studies	34% ± 14%	Explore
kidney	6 studies	22% ± 5%	Explore
eye	6 studies	28% ± 11%	Explore
intestine	5 studies	22% ± 10%	Explore
liver	5 studies	30% ± 14%	Explore
lymph node	5 studies	23% ± 7%	Explore
adipose	4 studies	17% ± 1%	Explore
placenta	3 studies	24% ± 3%	Explore
heart	3 studies	15% ± 0%	Explore
uterus	3 studies	28% ± 16%	Explore
bone marrow	3 studies	20% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3358.16	2642 / 2642	100%	94.91	705 / 705
esophagus	100%	5047.11	1445 / 1445	100%	80.87	183 / 183
ovary	100%	4140.56	180 / 180	100%	80.13	430 / 430
breast	100%	4113.88	459 / 459	100%	61.81	1117 / 1118
intestine	100%	3659.61	966 / 966	100%	69.67	526 / 527
prostate	100%	3538.27	245 / 245	100%	54.11	501 / 502
thymus	100%	3637.62	653 / 653	100%	59.32	603 / 605
lung	100%	2978.07	576 / 578	100%	72.79	1155 / 1155
stomach	100%	2947.58	359 / 359	100%	67.02	285 / 286
bladder	100%	4289.67	21 / 21	100%	61.21	502 / 504
kidney	100%	3225.69	89 / 89	99%	104.78	896 / 901
uterus	100%	3708.77	170 / 170	99%	66.97	455 / 459
pancreas	99%	2263.85	326 / 328	98%	45.77	175 / 178
adrenal gland	100%	4247.34	258 / 258	97%	45.71	224 / 230
skin	100%	4819.81	1809 / 1809	97%	63.36	456 / 472
liver	100%	2302.50	226 / 226	95%	32.37	387 / 406
adipose	100%	4074.58	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4059.88	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	78.30	29 / 29
muscle	100%	4322.27	803 / 803	0%	0	0 / 0
spleen	100%	3036.53	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	65.09	45 / 45
ureter	0%	0	0 / 0	100%	21.95	1 / 1
heart	98%	3010.69	846 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	45.64	76 / 80
peripheral blood	68%	3210.76	633 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006412	Biological process	translation
GO_0006422	Biological process	aspartyl-tRNA aminoacylation
GO_0065003	Biological process	protein-containing complex assembly
GO_0070062	Cellular component	extracellular exosome
GO_0017101	Cellular component	aminoacyl-tRNA synthetase multienzyme complex
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0004046	Molecular function	aminoacylase activity
GO_0004815	Molecular function	aspartate-tRNA ligase activity
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	DARS1
Protein name	Aspartyl-tRNA synthetase Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12) (Aspartyl-tRNA synthetase) (AspRS) (Cell proliferation-inducing gene 40 protein) Aspartate--tRNA ligase, cytoplasmic (EC 6.1.1.12)
Synonyms	DARS PIG40
Description	FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. . FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. . FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. .
Accessions	C9J7S3 ENST00000449218.5 C9JQM9 ENST00000422708.3 Q53R85 ENST00000456565.5 Q53T60 H7BZ35 ENST00000441323.5 C9JLC1 ENST00000264161.9 [P14868-1] P14868

DARS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review