SLURP2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLURP2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLURP2 at tissue level.

III. Associated gene sets

GO_0095500Biological processacetylcholine receptor signaling pathway
GO_0099601Biological processregulation of neurotransmitter receptor activity
GO_0005615Cellular componentextracellular space
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0030548Molecular functionacetylcholine receptor regulator activity
GO_0033130Molecular functionacetylcholine receptor binding

IV. Literature review

[source]
Gene nameSLURP2
Protein nameSecreted Ly-6/uPAR domain-containing protein 2 (Secreted LY6/PLAUR domain-containing protein 2) (Secreted Ly-6/uPAR-related protein 2) (SLURP-2)
Secreted LY6/PLAUR domain containing 2
Synonyms
DescriptionFUNCTION: Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner. .

AccessionsENST00000521396.1
ENST00000317543.12
H0YB12
P0DP57