SLC3A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015821Biological processmethionine transport
GO_0015823Biological processphenylalanine transport
GO_0070327Biological processthyroid hormone transport
GO_0043330Biological processresponse to exogenous dsRNA
GO_0005975Biological processcarbohydrate metabolic process
GO_0015820Biological processL-leucine transport
GO_0015818Biological processisoleucine transport
GO_0046718Biological processsymbiont entry into host cell
GO_0015829Biological processvaline transport
GO_0015824Biological processproline transport
GO_0015828Biological processtyrosine transport
GO_0006865Biological processamino acid transport
GO_1902024Biological processL-histidine transport
GO_1903801Biological processL-leucine import across plasma membrane
GO_1904273Biological processL-alanine import across plasma membrane
GO_0006816Biological processcalcium ion transport
GO_0015827Biological processtryptophan transport
GO_0035725Biological processsodium ion transmembrane transport
GO_0016323Cellular componentbasolateral plasma membrane
GO_0016324Cellular componentapical plasma membrane
GO_0044225Cellular componentapical pole of neuron
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0009925Cellular componentbasal plasma membrane
GO_1990184Cellular componentamino acid transport complex
GO_0009986Cellular componentcell surface
GO_0045202Cellular componentsynapse
GO_0070161Cellular componentanchoring junction
GO_0042470Cellular componentmelanosome
GO_0005765Cellular componentlysosomal membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0015180Molecular functionL-alanine transmembrane transporter activity
GO_0045296Molecular functioncadherin binding
GO_0140272Molecular functionexogenous protein binding
GO_0005294Molecular functionneutral L-amino acid secondary active transmembrane transporter activity
GO_0001618Molecular functionvirus receptor activity
GO_0015175Molecular functionneutral L-amino acid transmembrane transporter activity
GO_0015173Molecular functionaromatic amino acid transmembrane transporter activity
GO_0003723Molecular functionRNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005432Molecular functioncalcium:sodium antiporter activity
GO_0005515Molecular functionprotein binding
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0015190Molecular functionL-leucine transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC3A2
Protein name4F2 cell-surface antigen heavy chain
Solute carrier family 3 member 2
Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)
SynonymsMDU1
DescriptionFUNCTION: Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters . Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids . Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane . SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane (By similarity). SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA . SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8 . When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation . Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression . .; FUNCTION: (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis. .; FUNCTION: (Microbial infection) Acts as a receptor for malaria parasite Plasmodium vivax (Thai isolate) in immature red blood cells. .

AccessionsENST00000680631.1 [P08195-2]
ENST00000681467.1
P08195
ENST00000377890.6 [P08195-1]
A0A7P0Z4A0
F5GZS6
F5H0E2
ENST00000338663.12 [P08195-2]
ENST00000539507.1
ENST00000538084.2 [P08195-4]
F5H867
A0A7P0TAT7
ENST00000680725.1
ENST00000680002.1
ENST00000680297.1
F5GZR9
F5H056
ENST00000680729.1
ENST00000544377.2 [P08195-2]
ENST00000681107.1
ENST00000544377
H0YH36
H0YFS2
ENST00000377889.6 [P08195-3]
F5GZI0
A0A7P0Z4P5
A0A7P0TAN7
H0YFX4
A0A7P0TAS6
A0A7P0TBF8
ENST00000538084
A0A7P0T853
ENST00000536981.6
ENST00000679908.1
ENST00000377891.6 [P08195-5]
ENST00000535296.5
ENST00000541425.6
ENST00000539458.1
A0A7P0T8F1
ENST00000680610.1
ENST00000541372.1
A0A7P0T8U7
A0A7P0T9F7
ENST00000680134.1
ENST00000539891.6
ENST00000681569.1
ENST00000681657.1 [P08195-2]
ENST00000681232.1