Insufficient scRNA-seq data for expression of ITGB3 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 2338.56 | 89 / 89 | 89% | 18.85 | 803 / 901 |
| thymus | 100% | 5032.94 | 652 / 653 | 85% | 59.93 | 513 / 605 |
| skin | 63% | 1016.66 | 1135 / 1809 | 84% | 60.53 | 398 / 472 |
| breast | 91% | 1030.67 | 418 / 459 | 54% | 4.13 | 599 / 1118 |
| lung | 85% | 1015.06 | 491 / 578 | 42% | 4.56 | 485 / 1155 |
| uterus | 97% | 1668.96 | 165 / 170 | 27% | 4.57 | 125 / 459 |
| intestine | 89% | 2328.26 | 858 / 966 | 34% | 2.14 | 179 / 527 |
| esophagus | 69% | 1276.50 | 998 / 1445 | 51% | 3.95 | 93 / 183 |
| bladder | 81% | 1439.24 | 17 / 21 | 29% | 2.49 | 147 / 504 |
| prostate | 64% | 755.06 | 158 / 245 | 38% | 1.92 | 190 / 502 |
| blood vessel | 100% | 4786.40 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| stomach | 52% | 532.28 | 185 / 359 | 44% | 3.17 | 125 / 286 |
| adipose | 95% | 1314.87 | 1143 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 24% | 199.15 | 43 / 180 | 45% | 5.21 | 194 / 430 |
| pancreas | 1% | 4.66 | 3 / 328 | 67% | 5.03 | 120 / 178 |
| peripheral blood | 68% | 939.92 | 633 / 929 | 0% | 0 | 0 / 0 |
| heart | 63% | 529.21 | 544 / 861 | 0% | 0 | 0 / 0 |
| spleen | 54% | 400.44 | 130 / 241 | 0% | 0 | 0 / 0 |
| liver | 13% | 109.03 | 29 / 226 | 20% | 1.20 | 81 / 406 |
| brain | 2% | 18.34 | 63 / 2642 | 23% | 1.73 | 161 / 705 |
| adrenal gland | 4% | 22.61 | 10 / 258 | 20% | 1.57 | 47 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.55 | 4 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 0.71 | 6 / 45 |
| muscle | 9% | 58.99 | 72 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.04 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0072126 | Biological process | positive regulation of glomerular mesangial cell proliferation |
| GO_0048146 | Biological process | positive regulation of fibroblast proliferation |
| GO_0033627 | Biological process | cell adhesion mediated by integrin |
| GO_0071260 | Biological process | cellular response to mechanical stimulus |
| GO_0070527 | Biological process | platelet aggregation |
| GO_0060055 | Biological process | angiogenesis involved in wound healing |
| GO_0045124 | Biological process | regulation of bone resorption |
| GO_0014823 | Biological process | response to activity |
| GO_0030168 | Biological process | platelet activation |
| GO_0007044 | Biological process | cell-substrate junction assembly |
| GO_1901163 | Biological process | regulation of trophoblast cell migration |
| GO_1900026 | Biological process | positive regulation of substrate adhesion-dependent cell spreading |
| GO_0070374 | Biological process | positive regulation of ERK1 and ERK2 cascade |
| GO_1990314 | Biological process | cellular response to insulin-like growth factor stimulus |
| GO_2000352 | Biological process | negative regulation of endothelial cell apoptotic process |
| GO_0071466 | Biological process | cellular response to xenobiotic stimulus |
| GO_0150054 | Biological process | regulation of postsynaptic neurotransmitter receptor diffusion trapping |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0010763 | Biological process | positive regulation of fibroblast migration |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0032880 | Biological process | regulation of protein localization |
| GO_0007155 | Biological process | cell adhesion |
| GO_0034113 | Biological process | heterotypic cell-cell adhesion |
| GO_0014911 | Biological process | positive regulation of smooth muscle cell migration |
| GO_0042060 | Biological process | wound healing |
| GO_0032147 | Biological process | activation of protein kinase activity |
| GO_0043277 | Biological process | apoptotic cell clearance |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0034446 | Biological process | substrate adhesion-dependent cell spreading |
| GO_0035295 | Biological process | tube development |
| GO_0098880 | Biological process | maintenance of postsynaptic specialization structure |
| GO_0051279 | Biological process | regulation of release of sequestered calcium ion into cytosol |
| GO_0030949 | Biological process | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| GO_2000406 | Biological process | positive regulation of T cell migration |
| GO_0035313 | Biological process | wound healing, spreading of epidermal cells |
| GO_0036120 | Biological process | cellular response to platelet-derived growth factor stimulus |
| GO_0007566 | Biological process | embryo implantation |
| GO_0051611 | Biological process | regulation of serotonin uptake |
| GO_0033630 | Biological process | positive regulation of cell adhesion mediated by integrin |
| GO_0033690 | Biological process | positive regulation of osteoblast proliferation |
| GO_0072378 | Biological process | blood coagulation, fibrin clot formation |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0001934 | Biological process | positive regulation of protein phosphorylation |
| GO_0007596 | Biological process | blood coagulation |
| GO_0048333 | Biological process | mesodermal cell differentiation |
| GO_0050919 | Biological process | negative chemotaxis |
| GO_0010745 | Biological process | negative regulation of macrophage derived foam cell differentiation |
| GO_0032369 | Biological process | negative regulation of lipid transport |
| GO_0046718 | Biological process | symbiont entry into host cell |
| GO_0099149 | Biological process | regulation of postsynaptic neurotransmitter receptor internalization |
| GO_0050748 | Biological process | negative regulation of lipoprotein metabolic process |
| GO_0010888 | Biological process | negative regulation of lipid storage |
| GO_0016477 | Biological process | cell migration |
| GO_0031589 | Biological process | cell-substrate adhesion |
| GO_0014909 | Biological process | smooth muscle cell migration |
| GO_1900731 | Biological process | positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway |
| GO_0007160 | Biological process | cell-matrix adhesion |
| GO_0010595 | Biological process | positive regulation of endothelial cell migration |
| GO_0001954 | Biological process | positive regulation of cell-matrix adhesion |
| GO_1905598 | Biological process | negative regulation of low-density lipoprotein receptor activity |
| GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
| GO_0050731 | Biological process | positive regulation of peptidyl-tyrosine phosphorylation |
| GO_0001938 | Biological process | positive regulation of endothelial cell proliferation |
| GO_0038027 | Biological process | apolipoprotein A-I-mediated signaling pathway |
| GO_1903053 | Biological process | regulation of extracellular matrix organization |
| GO_0045780 | Biological process | positive regulation of bone resorption |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0034683 | Cellular component | integrin alphav-beta3 complex |
| GO_0071133 | Cellular component | alpha9-beta1 integrin-ADAM8 complex |
| GO_0008305 | Cellular component | integrin complex |
| GO_0031527 | Cellular component | filopodium membrane |
| GO_0009986 | Cellular component | cell surface |
| GO_0071062 | Cellular component | alphav-beta3 integrin-vitronectin complex |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0070442 | Cellular component | integrin alphaIIb-beta3 complex |
| GO_0005634 | Cellular component | nucleus |
| GO_0098690 | Cellular component | glycinergic synapse |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0035868 | Cellular component | alphav-beta3 integrin-HMGB1 complex |
| GO_0009897 | Cellular component | external side of plasma membrane |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0031528 | Cellular component | microvillus membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0035866 | Cellular component | alphav-beta3 integrin-PKCalpha complex |
| GO_0031258 | Cellular component | lamellipodium membrane |
| GO_0035867 | Cellular component | alphav-beta3 integrin-IGF-1-IGF1R complex |
| GO_0032587 | Cellular component | ruffle membrane |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0031092 | Cellular component | platelet alpha granule membrane |
| GO_0045202 | Cellular component | synapse |
| GO_0042470 | Cellular component | melanosome |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0001618 | Molecular function | virus receptor activity |
| GO_0005080 | Molecular function | protein kinase C binding |
| GO_0015026 | Molecular function | coreceptor activity |
| GO_0070051 | Molecular function | fibrinogen binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0050839 | Molecular function | cell adhesion molecule binding |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0019960 | Molecular function | C-X3-C chemokine binding |
| GO_0001968 | Molecular function | fibronectin binding |
| GO_0031994 | Molecular function | insulin-like growth factor I binding |
| GO_0043184 | Molecular function | vascular endothelial growth factor receptor 2 binding |
| GO_0002020 | Molecular function | protease binding |
| GO_0050840 | Molecular function | extracellular matrix binding |
| GO_0003756 | Molecular function | protein disulfide isomerase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005161 | Molecular function | platelet-derived growth factor receptor binding |
| GO_0005178 | Molecular function | integrin binding |
| GO_0038132 | Molecular function | neuregulin binding |
| GO_0017134 | Molecular function | fibroblast growth factor binding |
| Gene name | ITGB3 |
| Protein name | Integrin beta Platelet glycoprotein IIIa Truncated CD61 Integrin beta 3 (Integrin subunit beta 3) Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) |
| Synonyms | beta integrin 3 GP3A |
| Description | FUNCTION: Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling . ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling . ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling . ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling . ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling . ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling . ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling . ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 . ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 . In brain, plays a role in synaptic transmission and plasticity. Involved in the regulation of the serotonin neurotransmission, is required to localize to specific compartments within the synapse the serotonin receptor SLC6A4 and for an appropriate reuptake of serotonin. Controls excitatory synaptic strength by regulating GRIA2-containing AMPAR endocytosis, which affects AMPAR abundance and composition (By similarity). ITGAV:ITGB3 act as a receptor for CD40LG . ITGAV:ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP . .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9. .; FUNCTION: (Microbial infection) Acts as a receptor for Hantaan virus. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5. .; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB3 acts as a receptor for Human metapneumovirus. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1. .; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. .; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. . |
| Accessions | F1C630 ENST00000573377.1 P05106 F1C632 ENST00000696963.1 [P05106-2] F1C634 L7UUZ7 ENST00000559488.7 [P05106-1] A0A5E4DMZ9 L7UW06 A0A6B9NYH9 A7U833 ENST00000571680.1 I3L4X8 F2X0V0 F1C633 Q1PBM2 Q16157 L7WKL1 F2X0U9 |
