GPC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0014037Biological processSchwann cell differentiation
GO_2001016Biological processpositive regulation of skeletal muscle cell differentiation
GO_0032288Biological processmyelin assembly
GO_0030200Biological processheparan sulfate proteoglycan catabolic process
GO_1905475Biological processregulation of protein localization to membrane
GO_0016477Biological processcell migration
GO_0040037Biological processnegative regulation of fibroblast growth factor receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005796Cellular componentGolgi lumen
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0043202Cellular componentlysosomal lumen
GO_0098552Cellular componentside of membrane
GO_0005768Cellular componentendosome
GO_0043236Molecular functionlaminin binding
GO_0005507Molecular functioncopper ion binding
GO_0017134Molecular functionfibroblast growth factor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGPC1
Protein nameGlypican-1
Glypican-1 [Cleaved into: Secreted glypican-1]
Synonyms
DescriptionFUNCTION: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. .

FUNCTION: Cell surface proteoglycan. .

FUNCTION: Cell surface proteoglycan. .

FUNCTION: Cell surface proteoglycan. .

FUNCTION: Cell surface proteoglycan. .

FUNCTION: Cell surface proteoglycan. .

AccessionsC9J4Y6
ENST00000426280.3
ENST00000264039.7 [P35052-1]
H7BZL4
P35052
ENST00000455111.1
ENST00000425056.5
ENST00000427506.5
H7C410
H7BZE9
H7C024
ENST00000420138.5