Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 16 studies | 42% ± 23% | |
| glutamatergic neuron | 12 studies | 47% ± 25% | |
| GABAergic neuron | 7 studies | 45% ± 20% | |
| amacrine cell | 6 studies | 25% ± 8% | |
| neuron | 5 studies | 22% ± 6% | |
| interneuron | 5 studies | 48% ± 23% | |
| endothelial cell | 3 studies | 32% ± 11% | |
| GABAergic interneuron | 3 studies | 28% ± 7% | |
| granule cell | 3 studies | 31% ± 12% | |
| GABAergic amacrine cell | 3 studies | 38% ± 7% | |
| glycinergic amacrine cell | 3 studies | 32% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 12 studies | 33% ± 22% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 97% | 3024.78 | 2569 / 2642 | 62% | 4.20 | 439 / 705 |
| intestine | 61% | 298.60 | 593 / 966 | 28% | 0.95 | 145 / 527 |
| kidney | 63% | 275.37 | 56 / 89 | 4% | 0.20 | 35 / 901 |
| breast | 44% | 194.98 | 201 / 459 | 4% | 0.12 | 40 / 1118 |
| stomach | 4% | 13.86 | 14 / 359 | 27% | 1.08 | 76 / 286 |
| adipose | 24% | 92.00 | 289 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 18% | 90.42 | 44 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 4% | 11.35 | 57 / 1445 | 11% | 0.70 | 21 / 183 |
| pancreas | 0% | 0 | 0 / 328 | 11% | 0.22 | 19 / 178 |
| skin | 1% | 1.73 | 11 / 1809 | 9% | 0.72 | 44 / 472 |
| bladder | 0% | 0 | 0 / 21 | 10% | 0.49 | 48 / 504 |
| uterus | 3% | 8.55 | 5 / 170 | 6% | 0.20 | 26 / 459 |
| liver | 0% | 0 | 0 / 226 | 7% | 0.37 | 29 / 406 |
| lung | 1% | 2.42 | 5 / 578 | 5% | 0.20 | 52 / 1155 |
| prostate | 1% | 2.25 | 2 / 245 | 4% | 0.13 | 21 / 502 |
| blood vessel | 5% | 15.70 | 64 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 3% | 10.08 | 6 / 180 | 1% | 0.03 | 4 / 430 |
| adrenal gland | 0% | 0 | 0 / 258 | 4% | 0.20 | 9 / 230 |
| thymus | 1% | 2.27 | 5 / 653 | 0% | 0.01 | 2 / 605 |
| heart | 1% | 1.49 | 5 / 861 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.42 | 1 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0099505 | Biological process | regulation of presynaptic membrane potential |
| GO_1904862 | Biological process | inhibitory synapse assembly |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0051932 | Biological process | synaptic transmission, GABAergic |
| GO_0007214 | Biological process | gamma-aminobutyric acid signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_1902495 | Cellular component | transmembrane transporter complex |
| GO_0060077 | Cellular component | inhibitory synapse |
| GO_0030672 | Cellular component | synaptic vesicle membrane |
| GO_0098794 | Cellular component | postsynapse |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0043005 | Cellular component | neuron projection |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0045202 | Cellular component | synapse |
| GO_1902711 | Cellular component | GABA-A receptor complex |
| GO_0030424 | Cellular component | axon |
| GO_0099634 | Cellular component | postsynaptic specialization membrane |
| GO_0032590 | Cellular component | dendrite membrane |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0004890 | Molecular function | GABA-A receptor activity |
| GO_0005254 | Molecular function | chloride channel activity |
| GO_0022851 | Molecular function | GABA-gated chloride ion channel activity |
| GO_0099507 | Molecular function | ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| GO_0005515 | Molecular function | protein binding |
| GO_0008503 | Molecular function | benzodiazepine receptor activity |
| Gene name | GABRA2 |
| Protein name | Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2) Gamma-aminobutyric acid type A receptor subunit alpha2 Gamma-aminobutyric acid A receptor alpha 2 isoform 5 Gamma-aminobutyric acid A receptor alpha 2 isoform 4 Gamma-aminobutyric acid A receptor alpha 2 isoform 3 Gamma-aminobutyric acid A receptor alpha 2 isoform 2 (Gamma-aminobutyric acid type A receptor subunit alpha2) Uncharacterized protein GABRA2 |
| Synonyms | hCG_15318 |
| Description | FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). . |
| Accessions | ENST00000514236.1 A0A0A0MTM5 A0A0S2Z3Q9 P47869 ENST00000506961.5 ENST00000540012.5 ENST00000507069.5 E9PBQ7 H0Y9V8 D6RCS5 Q4W5L8 A0A0S2Z3U7 ENST00000514193.5 ENST00000515082.5 D6RBL7 Q8TBI4 ENST00000510233.5 ENST00000630416.2 D6RB77 ENST00000510861.5 [P47869-1] A0A0S2Z3R1 ENST00000381620.9 [P47869-1] ENST00000503806.5 ENST00000507460.1 G5E9Z6 ENST00000513005.5 ENST00000514090.5 [P47869-1] ENST00000356504.5 [P47869-1] D6RBK9 D6RAA9 |
