HRH2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0045907Biological processpositive regulation of vasoconstriction
GO_0001696Biological processgastric acid secretion
GO_0007268Biological processchemical synaptic transmission
GO_0098664Biological processG protein-coupled serotonin receptor signaling pathway
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0004969Molecular functionhistamine receptor activity

IV. Literature review

[source]
Gene nameHRH2
Protein nameHistamine H2 receptor (H2R) (HH2R) (Gastric receptor I)
Histamine H2 receptor (Gastric receptor I)
Synonyms
DescriptionFUNCTION: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity). .

AccessionsENST00000636584.2
ENST00000624694.2
A0A1B0GVZ0
P25021
A0A1B0GTK7
ENST00000377291.2 [P25021-2]