MBP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	41 studies	42% ± 14%	Explore
CD8-positive, alpha-beta T cell	33 studies	30% ± 11%	Explore
CD4-positive, alpha-beta T cell	29 studies	28% ± 8%	Explore
B cell	28 studies	23% ± 6%	Explore
macrophage	26 studies	30% ± 16%	Explore
T cell	24 studies	29% ± 8%	Explore
mast cell	21 studies	28% ± 11%	Explore
regulatory T cell	21 studies	27% ± 9%	Explore
conventional dendritic cell	20 studies	28% ± 12%	Explore
mature NK T cell	20 studies	40% ± 11%	Explore
classical monocyte	19 studies	25% ± 10%	Explore
gamma-delta T cell	18 studies	39% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	45% ± 12%	Explore
plasmacytoid dendritic cell	16 studies	32% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	51% ± 13%	Explore
ciliated cell	16 studies	34% ± 16%	Explore
oligodendrocyte	16 studies	88% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	31% ± 12%	Explore
non-classical monocyte	15 studies	27% ± 9%	Explore
memory B cell	15 studies	23% ± 6%	Explore
naive B cell	14 studies	25% ± 7%	Explore
dendritic cell	13 studies	43% ± 20%	Explore
monocyte	13 studies	31% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	37% ± 9%	Explore
microglial cell	13 studies	43% ± 18%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	34% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	34% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	43% ± 14%	Explore
oligodendrocyte precursor cell	12 studies	44% ± 18%	Explore
mucosal invariant T cell	12 studies	28% ± 7%	Explore
innate lymphoid cell	10 studies	37% ± 14%	Explore
endothelial cell	10 studies	28% ± 13%	Explore
myeloid cell	9 studies	35% ± 12%	Explore
neutrophil	8 studies	25% ± 8%	Explore
GABAergic neuron	8 studies	41% ± 14%	Explore
glutamatergic neuron	8 studies	40% ± 19%	Explore
epithelial cell	8 studies	37% ± 21%	Explore
fibroblast	8 studies	25% ± 7%	Explore
leukocyte	7 studies	44% ± 19%	Explore
basal cell	7 studies	35% ± 21%	Explore
T follicular helper cell	7 studies	29% ± 8%	Explore
type I pneumocyte	7 studies	22% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	38% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	39% ± 13%	Explore
mononuclear phagocyte	6 studies	24% ± 8%	Explore
astrocyte	6 studies	44% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	35% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	29% ± 8%	Explore
platelet	5 studies	28% ± 7%	Explore
lymphocyte	5 studies	47% ± 13%	Explore
club cell	5 studies	20% ± 5%	Explore
mesothelial cell	5 studies	30% ± 13%	Explore
type II pneumocyte	5 studies	25% ± 6%	Explore
hematopoietic stem cell	5 studies	25% ± 5%	Explore
goblet cell	5 studies	32% ± 20%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
exhausted T cell	4 studies	35% ± 6%	Explore
secretory cell	4 studies	24% ± 14%	Explore
hematopoietic precursor cell	4 studies	31% ± 15%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	54% ± 24%	Explore
neuron	4 studies	44% ± 11%	Explore
megakaryocyte	4 studies	31% ± 9%	Explore
precursor B cell	4 studies	22% ± 5%	Explore
immature B cell	4 studies	21% ± 3%	Explore
CD4-positive helper T cell	4 studies	36% ± 10%	Explore
brush cell	4 studies	30% ± 10%	Explore
respiratory goblet cell	4 studies	35% ± 10%	Explore
alveolar macrophage	4 studies	39% ± 16%	Explore
melanocyte	4 studies	40% ± 26%	Explore
abnormal cell	4 studies	23% ± 4%	Explore
renal principal cell	4 studies	23% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	24% ± 1%	Explore
pancreatic A cell	3 studies	29% ± 8%	Explore
squamous epithelial cell	3 studies	37% ± 26%	Explore
retinal bipolar neuron	3 studies	27% ± 8%	Explore
retinal pigment epithelial cell	3 studies	43% ± 23%	Explore
cardiac muscle cell	3 studies	18% ± 1%	Explore
rod bipolar cell	3 studies	28% ± 4%	Explore
hepatocyte	3 studies	43% ± 33%	Explore
granulocyte	3 studies	30% ± 13%	Explore
enteroendocrine cell	3 studies	27% ± 6%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 12%	Explore
transit amplifying cell	3 studies	40% ± 33%	Explore
T-helper 17 cell	3 studies	24% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	27% ± 9%	Explore
double negative thymocyte	3 studies	36% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	34% ± 10%	Explore
brain	15 studies	44% ± 21%	Explore
lung	12 studies	25% ± 9%	Explore
liver	5 studies	24% ± 8%	Explore
pancreas	3 studies	28% ± 12%	Explore
bone marrow	3 studies	31% ± 6%	Explore
kidney	3 studies	20% ± 2%	Explore
intestine	3 studies	19% ± 2%	Explore
adipose	3 studies	25% ± 5%	Explore
lymph node	3 studies	25% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	746431.56	2632 / 2642	99%	263.09	695 / 705
eye	0%	0	0 / 0	99%	32.02	79 / 80
prostate	0%	0	0 / 245	98%	12.60	493 / 502
esophagus	0%	90.70	4 / 1445	96%	8.46	176 / 183
stomach	0%	0	0 / 359	96%	7.74	275 / 286
thymus	0%	130.93	1 / 653	96%	12.05	578 / 605
kidney	0%	0	0 / 89	95%	10.94	857 / 901
intestine	0%	95.63	2 / 966	95%	7.81	499 / 527
skin	0%	122.94	3 / 1809	95%	43.00	447 / 472
lung	0%	0	0 / 578	94%	8.95	1091 / 1155
pancreas	0%	0	0 / 328	94%	8.16	168 / 178
tonsil	0%	0	0 / 0	93%	9.49	42 / 45
lymph node	0%	0	0 / 0	93%	13.60	27 / 29
uterus	0%	0	0 / 170	81%	6.39	373 / 459
ovary	1%	498.01	1 / 180	80%	5.76	345 / 430
bladder	0%	0	0 / 21	77%	5.72	389 / 504
breast	0%	126.25	2 / 459	75%	5.90	842 / 1118
liver	0%	0	0 / 226	73%	4.63	295 / 406
adrenal gland	0%	0	0 / 258	17%	0.86	39 / 230
peripheral blood	6%	1414.83	55 / 929	0%	0	0 / 0
adipose	1%	225.00	9 / 1204	0%	0	0 / 0
muscle	0%	77.95	3 / 803	0%	0	0 / 0
heart	0%	99.28	1 / 861	0%	0	0 / 0
blood vessel	0%	17.57	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007605	Biological process	sensory perception of sound
GO_0042552	Biological process	myelination
GO_0000165	Biological process	MAPK cascade
GO_0061024	Biological process	membrane organization
GO_1904685	Biological process	positive regulation of metalloendopeptidase activity
GO_2000343	Biological process	positive regulation of chemokine (C-X-C motif) ligand 2 production
GO_0034115	Biological process	negative regulation of heterotypic cell-cell adhesion
GO_0006955	Biological process	immune response
GO_0007268	Biological process	chemical synaptic transmission
GO_0035633	Biological process	maintenance of blood-brain barrier
GO_0008366	Biological process	axon ensheathment
GO_0021762	Biological process	substantia nigra development
GO_0007417	Biological process	central nervous system development
GO_0009636	Biological process	response to toxic substance
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0043209	Cellular component	myelin sheath
GO_0005886	Cellular component	plasma membrane
GO_0032991	Cellular component	protein-containing complex
GO_0043025	Cellular component	neuronal cell body
GO_0009986	Cellular component	cell surface
GO_0005829	Cellular component	cytosol
GO_0071944	Cellular component	cell periphery
GO_0045202	Cellular component	synapse
GO_0043218	Cellular component	compact myelin
GO_0033269	Cellular component	internode region of axon
GO_0005634	Cellular component	nucleus
GO_0019911	Molecular function	structural constituent of myelin sheath
GO_0002020	Molecular function	protease binding
GO_0005516	Molecular function	calmodulin binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	MBP
Protein name	Myelin basic protein Myelin basic protein (MBP) (Myelin A1 protein) (Myelin membrane encephalitogenic protein)
Synonyms
Description	FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. .
Accessions	E9PNZ1 J3QQK6 ENST00000578873.5 ENST00000473302.5 ENST00000354542.4 J3QKN5 E9PKX9 ENST00000583798.1 P02686 ENST00000483025.5 ENST00000577755.5 ENST00000493623.5 ENST00000359645.7 [P02686-4] E9PLU9 E9PQE7 ENST00000397865.9 [P02686-6] ENST00000397866.8 [P02686-5] ENST00000382582.7 [P02686-3] ENST00000581878.5 J3KT01 ENST00000583474.5 J3KS94 H7BYR8 ENST00000533278.5 ENST00000531144.5 ENST00000397863.5 [P02686-2] ENST00000355994.7 [P02686-1] ENST00000585201.5 ENST00000578193.5 H0YEA2 ENST00000528160.1 ENST00000527975.5 F8WEU6 ENST00000580402.5 [P02686-1] ENST00000397860.7 [P02686-2] ENST00000397869.7 ENST00000459948.1 H0YF02 E9PMR5 E9PJ72 E9PSE2 J3KT34 ENST00000526111.5 ENST00000498683.2 C9J6H1 ENST00000579129.5 ENST00000447114.5 ENST00000527041.1 J3QKL5 A8MZH3 ENST00000397875.7 F5H7N4 J3QL64 E9PLQ9

MBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review