I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 8 studies | 37% ± 9% | |
| rod bipolar cell | 3 studies | 29% ± 11% | |
| GABAergic neuron | 3 studies | 34% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 8 studies | 37% ± 9% | |
| rod bipolar cell | 3 studies | 29% ± 11% | |
| GABAergic neuron | 3 studies | 34% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 22% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 92% | 7760.41 | 2430 / 2642 | 99% | 41.98 | 695 / 705 |
| breast | 75% | 4774.52 | 342 / 459 | 64% | 3.34 | 720 / 1118 |
| ovary | 47% | 578.86 | 84 / 180 | 70% | 1.67 | 300 / 430 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.22 | 1 / 1 |
| heart | 96% | 14456.04 | 826 / 861 | 0% | 0 | 0 / 0 |
| adipose | 93% | 6286.02 | 1118 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 8.09 | 26 / 29 |
| skin | 2% | 22.18 | 31 / 1809 | 83% | 3.49 | 393 / 472 |
| uterus | 20% | 213.19 | 34 / 170 | 57% | 1.29 | 262 / 459 |
| adrenal gland | 5% | 60.60 | 14 / 258 | 69% | 7.14 | 159 / 230 |
| pancreas | 0% | 0 | 0 / 328 | 69% | 1.94 | 122 / 178 |
| bladder | 10% | 105.24 | 2 / 21 | 47% | 1.36 | 238 / 504 |
| eye | 0% | 0 | 0 / 0 | 54% | 1.63 | 43 / 80 |
| thymus | 2% | 38.05 | 15 / 653 | 49% | 0.93 | 299 / 605 |
| prostate | 11% | 125.58 | 28 / 245 | 39% | 0.63 | 196 / 502 |
| kidney | 0% | 0 | 0 / 89 | 49% | 1.12 | 437 / 901 |
| lung | 0% | 19.68 | 2 / 578 | 48% | 0.96 | 551 / 1155 |
| esophagus | 3% | 43.54 | 44 / 1445 | 40% | 0.71 | 73 / 183 |
| intestine | 5% | 79.49 | 53 / 966 | 32% | 0.69 | 170 / 527 |
| stomach | 1% | 30.42 | 4 / 359 | 36% | 0.78 | 104 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 29% | 0.55 | 13 / 45 |
| liver | 0% | 0 | 0 / 226 | 15% | 0.41 | 61 / 406 |
| blood vessel | 10% | 317.38 | 127 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 8% | 80.66 | 19 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 3% | 42.08 | 28 / 929 | 0% | 0 | 0 / 0 |
| muscle | 2% | 18.97 | 15 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0045163 | Biological process | clustering of voltage-gated potassium channels |
| GO_1901379 | Biological process | regulation of potassium ion transmembrane transport |
| GO_0007165 | Biological process | signal transduction |
| GO_0006936 | Biological process | muscle contraction |
| GO_0086013 | Biological process | membrane repolarization during cardiac muscle cell action potential |
| GO_1903766 | Biological process | positive regulation of potassium ion export across plasma membrane |
| GO_0097623 | Biological process | potassium ion export across plasma membrane |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_1903818 | Biological process | positive regulation of voltage-gated potassium channel activity |
| GO_0001508 | Biological process | action potential |
| GO_0086009 | Biological process | membrane repolarization |
| GO_0008016 | Biological process | regulation of heart contraction |
| GO_0005513 | Biological process | detection of calcium ion |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0034705 | Cellular component | potassium channel complex |
| GO_0030425 | Cellular component | dendrite |
| GO_0071193 | Cellular component | Kv4.2-KChIP2 channel complex |
| GO_0045202 | Cellular component | synapse |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0005250 | Molecular function | A-type (transient outward) potassium channel activity |
| GO_0044877 | Molecular function | protein-containing complex binding |
| GO_0086008 | Molecular function | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization |
| GO_0015459 | Molecular function | potassium channel regulator activity |
| GO_0044325 | Molecular function | transmembrane transporter binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0046923 | Molecular function | ER retention sequence binding |
| Gene name | KCNIP2 |
| Protein name | Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Cardiac voltage-gated potassium channel modulatory subunit) (Potassium channel-interacting protein 2) Kv channel interacting protein 2 Kv channel interacting protein 2 transcript variant 9 Potassium voltage-gated channel interacting protein 2 |
| Synonyms | KCHIP2 |
| Description | FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). . |
| Accessions | ENST00000343195.8 [Q9NS61-3] ENST00000239117.3 [Q9NS61-9] Q9NS61 Q09MK0 ENST00000642874.1 ENST00000356640.7 [Q9NS61-1] ENST00000461105.5 [Q9NS61-6] A6NFF4 A6QL43 ENST00000358038.7 [Q9NS61-2] ENST00000348850.9 [Q9NS61-4] ENST00000353068.7 [Q9NS61-7] ENST00000434163.5 [Q9NS61-8] ENST00000370046.5 A0A2R8Y6D7 |
