DNM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031623Biological processreceptor internalization
GO_0006897Biological processendocytosis
GO_0030516Biological processregulation of axon extension
GO_0006898Biological processreceptor-mediated endocytosis
GO_0007165Biological processsignal transduction
GO_0006892Biological processpost-Golgi vesicle-mediated transport
GO_0048489Biological processsynaptic vesicle transport
GO_1903526Biological processnegative regulation of membrane tubulation
GO_0061024Biological processmembrane organization
GO_0061572Biological processactin filament bundle organization
GO_0016185Biological processsynaptic vesicle budding from presynaptic endocytic zone membrane
GO_0007098Biological processcentrosome cycle
GO_0048812Biological processneuron projection morphogenesis
GO_0051258Biological processprotein polymerization
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006909Biological processphagocytosis
GO_0033572Biological processtransferrin transport
GO_0019886Biological processantigen processing and presentation of exogenous peptide antigen via MHC class II
GO_0097749Biological processmembrane tubulation
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0043149Biological processstress fiber assembly
GO_0006914Biological processautophagy
GO_0099050Biological processvesicle scission
GO_0043065Biological processpositive regulation of apoptotic process
GO_0098793Cellular componentpresynapse
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0055037Cellular componentrecycling endosome
GO_0030666Cellular componentendocytic vesicle membrane
GO_0005813Cellular componentcentrosome
GO_0002102Cellular componentpodosome
GO_0070062Cellular componentextracellular exosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0043005Cellular componentneuron projection
GO_0005925Cellular componentfocal adhesion
GO_0005814Cellular componentcentriole
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0001891Cellular componentphagocytic cup
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0005905Cellular componentclathrin-coated pit
GO_0005768Cellular componentendosome
GO_0001931Cellular componenturopod
GO_0019899Molecular functionenzyme binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005525Molecular functionGTP binding
GO_0008017Molecular functionmicrotubule binding
GO_0017124Molecular functionSH3 domain binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameDNM2
Protein nameDynamin II
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Dynamin 2
SynonymsDYN2
DescriptionFUNCTION: Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton . Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis . During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission . Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton . The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 , by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction . Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation . .

AccessionsP50570
K7ENE7
ENST00000591818.1
ENST00000408974.8 [P50570-3]
ENST00000587830.2
ENST00000585892.5 [P50570-5]
ENST00000586939.5
K7EMR9
ENST00000589106.1
ENST00000359692.10 [P50570-2]
K7EPK9
ENST00000389253.9 [P50570-4]
K7EMQ3
ENST00000355667.11 [P50570-1]
Q9UPH5