ERC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007274Biological processneuromuscular synaptic transmission
GO_0048790Biological processmaintenance of presynaptic active zone structure
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0048167Biological processregulation of synaptic plasticity
GO_0007252Biological processI-kappaB phosphorylation
GO_0006355Biological processregulation of DNA-templated transcription
GO_0015031Biological processprotein transport
GO_0005813Cellular componentcentrosome
GO_0042734Cellular componentpresynaptic membrane
GO_0000139Cellular componentGolgi membrane
GO_0048788Cellular componentcytoskeleton of presynaptic active zone
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0008385Cellular componentIkappaB kinase complex
GO_0036064Cellular componentciliary basal body
GO_0045296Molecular functioncadherin binding
GO_0031267Molecular functionsmall GTPase binding
GO_0030165Molecular functionPDZ domain binding
GO_0098882Molecular functionstructural constituent of presynaptic active zone
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameERC1
Protein nameELKS/RAB6-interacting/CAST family member 1
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)
SynonymsKIAA1081
ELKS
RAB6IP2
DescriptionFUNCTION: Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. .

AccessionsQ8IUD2
K7EPD6
X6RM00
ENST00000688324.1
ENST00000588412.5
ENST00000545318.3
A0A8I5KT07
A0A8I5KS52
X6RLX0
ENST00000347735.10 [Q8IUD2-4]
ENST00000440394.7 [Q8IUD2-2]
ENST00000360905.9 [Q8IUD2-1]
G8JLD3
ENST00000543086.7 [Q8IUD2-3]
ENST00000589028.6 [Q8IUD2-1]
ENST00000546231.6
ENST00000689995.1
ENST00000589132.1
ENST00000691177.1
ENST00000592048.5
ENST00000542302.6
K7EP25
ENST00000355446.9
ENST00000611180.5
A0A8I5QKW1
ENST00000539802.2
K7EIZ7
A0A8J9C065
ENST00000397203.7 [Q8IUD2-1]
K7EPP6
K7EKH8
ENST00000545948.5 [Q8IUD2-5]