SLC6A4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC6A4 at tissue level.

III. Associated gene sets

GO_0071300Biological processcellular response to retinoic acid
GO_0007584Biological processresponse to nutrient
GO_0032355Biological processresponse to estradiol
GO_0015844Biological processmonoamine transport
GO_0048484Biological processenteric nervous system development
GO_0051899Biological processmembrane depolarization
GO_0032227Biological processnegative regulation of synaptic transmission, dopaminergic
GO_1990708Biological processconditioned place preference
GO_0070527Biological processplatelet aggregation
GO_0010628Biological processpositive regulation of gene expression
GO_0046621Biological processnegative regulation of organ growth
GO_0071321Biological processcellular response to cGMP
GO_0090067Biological processregulation of thalamus size
GO_0042713Biological processsperm ejaculation
GO_0007623Biological processcircadian rhythm
GO_0045665Biological processnegative regulation of neuron differentiation
GO_0001666Biological processresponse to hypoxia
GO_0006836Biological processneurotransmitter transport
GO_0014064Biological processpositive regulation of serotonin secretion
GO_0051610Biological processserotonin uptake
GO_0007613Biological processmemory
GO_0048854Biological processbrain morphogenesis
GO_0006865Biological processamino acid transport
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0009636Biological processresponse to toxic substance
GO_0048148Biological processbehavioral response to cocaine
GO_0042310Biological processvasoconstriction
GO_0035176Biological processsocial behavior
GO_0021941Biological processnegative regulation of cerebellar granule cell precursor proliferation
GO_0035725Biological processsodium ion transmembrane transport
GO_0045787Biological processpositive regulation of cell cycle
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0012505Cellular componentendomembrane system
GO_0043005Cellular componentneuron projection
GO_0042734Cellular componentpresynaptic membrane
GO_0005925Cellular componentfocal adhesion
GO_0045202Cellular componentsynapse
GO_0045211Cellular componentpostsynaptic membrane
GO_0010008Cellular componentendosome membrane
GO_0099154Cellular componentserotonergic synapse
GO_0005335Molecular functionserotonin:sodium:chloride symporter activity
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0015297Molecular functionantiporter activity
GO_0050998Molecular functionnitric-oxide synthase binding
GO_0051015Molecular functionactin filament binding
GO_0042802Molecular functionidentical protein binding
GO_0008504Molecular functionmonoamine transmembrane transporter activity
GO_0005178Molecular functionintegrin binding
GO_0005261Molecular functionmonoatomic cation channel activity
GO_0017075Molecular functionsyntaxin-1 binding
GO_0019811Molecular functioncocaine binding
GO_0051378Molecular functionserotonin binding
GO_0005515Molecular functionprotein binding
GO_0031402Molecular functionsodium ion binding

IV. Literature review

[source]
Gene nameSLC6A4
Protein nameSodium-dependent serotonin transporter (SERT) (5HT transporter) (5HTT) (Solute carrier family 6 member 4)
Transporter
Serotonin transporter (Solute carrier family 6 member 4)
Solute carrier family 6 member 4
SynonymsHTT
5HTT
SERT
DescriptionFUNCTION: Serotonin transporter that cotransports serotonin with one Na(+) ion in exchange for one K(+) ion and possibly one proton in an overall electroneutral transport cycle. Transports serotonin across the plasma membrane from the extracellular compartment to the cytosol thus limiting serotonin intercellular signaling . Essential for serotonin homeostasis in the central nervous system. In the developing somatosensory cortex, acts in glutamatergic neurons to control serotonin uptake and its trophic functions accounting for proper spatial organization of cortical neurons and elaboration of sensory circuits. In the mature cortex, acts primarily in brainstem raphe neurons to mediate serotonin uptake from the synaptic cleft back into the pre-synaptic terminal thus terminating serotonin signaling at the synapse (By similarity). Modulates mucosal serotonin levels in the gastrointestinal tract through uptake and clearance of serotonin in enterocytes. Required for enteric neurogenesis and gastrointestinal reflexes (By similarity). Regulates blood serotonin levels by ensuring rapid high affinity uptake of serotonin from plasma to platelets, where it is further stored in dense granules via vesicular monoamine transporters and then released upon stimulation . Mechanistically, the transport cycle starts with an outward-open conformation having Na1(+) and Cl(-) sites occupied. The binding of a second extracellular Na2(+) ion and serotonin substrate leads to structural changes to outward-occluded to inward-occluded to inward-open, where the Na2(+) ion and serotonin are released into the cytosol. Binding of intracellular K(+) ion induces conformational transitions to inward-occluded to outward-open and completes the cycle by releasing K(+) possibly together with a proton bound to Asp-98 into the extracellular compartment. Na1(+) and Cl(-) ions remain bound throughout the transport cycle . Additionally, displays serotonin-induced channel-like conductance for monovalent cations, mainly Na(+) ions. The channel activity is uncoupled from the transport cycle and may contribute to the membrane resting potential or excitability (By similarity). .

AccessionsB3VRQ0
B3VRV5
P31645
B3VRW0
J3KPR9
B3VRS5
B3VRR5
B3VRU5
Q9NYN7
ENST00000579221.5
B3VRQ5
B3VRV0
B3VRS0
B3VRR0
B3VRU0
J3QKP3
ENST00000650711.1 [P31645-1]
ENST00000394821.2
ENST00000261707.7 [P31645-1]
B3VRT5
ENST00000401766.6 [P31645-1]