CHRNB4 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHRNB4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	92%	122.92	237 / 258	73%	19.34	167 / 230
esophagus	80%	44.53	1152 / 1445	44%	1.80	81 / 183
intestine	92%	101.12	893 / 966	5%	0.13	28 / 527
kidney	87%	23.11	77 / 89	4%	0.16	34 / 901
uterus	44%	13.34	75 / 170	45%	1.97	206 / 459
spleen	80%	28.89	193 / 241	0%	0	0 / 0
thymus	53%	10.59	346 / 653	22%	0.54	134 / 605
tonsil	0%	0	0 / 0	60%	2.21	27 / 45
ovary	28%	9.79	51 / 180	31%	0.74	135 / 430
stomach	45%	36.08	160 / 359	9%	0.20	26 / 286
bladder	38%	6.43	8 / 21	12%	0.29	62 / 504
skin	33%	6.29	593 / 1809	10%	0.28	48 / 472
lung	3%	0.38	17 / 578	33%	1.02	378 / 1155
brain	32%	7.35	855 / 2642	2%	0.05	15 / 705
breast	29%	5.44	131 / 459	5%	0.12	57 / 1118
prostate	24%	5.46	59 / 245	0%	0.00	1 / 502
adipose	19%	2.84	228 / 1204	0%	0	0 / 0
pancreas	10%	1.43	34 / 328	7%	0.13	13 / 178
liver	7%	0.85	15 / 226	3%	0.05	11 / 406
eye	0%	0	0 / 0	8%	0.18	6 / 80
heart	6%	1.15	49 / 861	0%	0	0 / 0
blood vessel	4%	0.66	54 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	3%	0.04	1 / 29
muscle	3%	0.54	26 / 803	0%	0	0 / 0
peripheral blood	1%	1.41	9 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0006939	Biological process	smooth muscle contraction
GO_0051899	Biological process	membrane depolarization
GO_0060079	Biological process	excitatory postsynaptic potential
GO_0007165	Biological process	signal transduction
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0006811	Biological process	monoatomic ion transport
GO_0095500	Biological process	acetylcholine receptor signaling pathway
GO_0006940	Biological process	regulation of smooth muscle contraction
GO_0035095	Biological process	behavioral response to nicotine
GO_0060084	Biological process	synaptic transmission involved in micturition
GO_0051971	Biological process	positive regulation of transmission of nerve impulse
GO_0046928	Biological process	regulation of neurotransmitter secretion
GO_0007268	Biological process	chemical synaptic transmission
GO_0019228	Biological process	neuronal action potential
GO_0007626	Biological process	locomotory behavior
GO_0007271	Biological process	synaptic transmission, cholinergic
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0043005	Cellular component	neuron projection
GO_0098981	Cellular component	cholinergic synapse
GO_0045202	Cellular component	synapse
GO_0070821	Cellular component	tertiary granule membrane
GO_0045211	Cellular component	postsynaptic membrane
GO_0005892	Cellular component	acetylcholine-gated channel complex
GO_0015464	Molecular function	acetylcholine receptor activity
GO_0015276	Molecular function	ligand-gated monoatomic ion channel activity
GO_0022848	Molecular function	acetylcholine-gated monoatomic cation-selective channel activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	CHRNB4
Protein name	Neuronal acetylcholine receptor subunit beta-4 Cholinergic receptor nicotinic beta 4 subunit
Synonyms
Description	FUNCTION: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Accessions	P30926 ENST00000261751.8 [P30926-1] ENST00000559849.5 ENST00000412074.6 [P30926-2] H3BU02

CHRNB4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review