CAMK2N1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050729Biological processpositive regulation of inflammatory response
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0007616Biological processlong-term memory
GO_0005575Cellular componentcellular_component
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0030425Cellular componentdendrite
GO_0019901Molecular functionprotein kinase binding
GO_0008427Molecular functioncalcium-dependent protein kinase inhibitor activity

IV. Literature review

[source]
Gene nameCAMK2N1
Protein nameCalcium/calmodulin-dependent protein kinase II inhibitor 1 (CaMKII inhibitory protein alpha) (CaMKIIN-alpha)
CAMK2N1 protein
Synonyms
DescriptionFUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity). .

AccessionsENST00000375078.4
Q7L2B8
Q7Z7J9