PPA2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
endothelial cell	19 studies	29% ± 12%	Explore
astrocyte	14 studies	34% ± 16%	Explore
oligodendrocyte precursor cell	13 studies	40% ± 20%	Explore
macrophage	13 studies	29% ± 12%	Explore
oligodendrocyte	12 studies	35% ± 14%	Explore
microglial cell	11 studies	27% ± 10%	Explore
fibroblast	11 studies	26% ± 12%	Explore
basal cell	11 studies	32% ± 18%	Explore
glutamatergic neuron	9 studies	45% ± 27%	Explore
smooth muscle cell	9 studies	19% ± 3%	Explore
epithelial cell	9 studies	40% ± 20%	Explore
GABAergic neuron	8 studies	44% ± 24%	Explore
ciliated cell	8 studies	28% ± 9%	Explore
conventional dendritic cell	7 studies	25% ± 10%	Explore
club cell	7 studies	29% ± 8%	Explore
dendritic cell	7 studies	30% ± 11%	Explore
type II pneumocyte	7 studies	31% ± 10%	Explore
epithelial cell of proximal tubule	6 studies	23% ± 7%	Explore
progenitor cell	6 studies	19% ± 2%	Explore
myeloid cell	6 studies	21% ± 4%	Explore
monocyte	6 studies	23% ± 6%	Explore
adipocyte	6 studies	20% ± 3%	Explore
goblet cell	6 studies	29% ± 15%	Explore
pericyte	6 studies	22% ± 9%	Explore
hematopoietic precursor cell	5 studies	29% ± 9%	Explore
natural killer cell	5 studies	17% ± 1%	Explore
neuron	5 studies	40% ± 15%	Explore
erythroblast	5 studies	35% ± 13%	Explore
amacrine cell	5 studies	29% ± 11%	Explore
retinal rod cell	5 studies	22% ± 4%	Explore
cardiac muscle cell	5 studies	28% ± 3%	Explore
endothelial cell of lymphatic vessel	5 studies	28% ± 5%	Explore
kidney loop of Henle epithelial cell	4 studies	23% ± 7%	Explore
connective tissue cell	4 studies	17% ± 2%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	17% ± 1%	Explore
T cell	4 studies	18% ± 1%	Explore
retinal ganglion cell	4 studies	41% ± 16%	Explore
myofibroblast cell	4 studies	21% ± 5%	Explore
retina horizontal cell	4 studies	32% ± 10%	Explore
retinal bipolar neuron	4 studies	24% ± 8%	Explore
retinal pigment epithelial cell	4 studies	36% ± 20%	Explore
mucus secreting cell	4 studies	26% ± 3%	Explore
vein endothelial cell	4 studies	25% ± 16%	Explore
endothelial cell of vascular tree	4 studies	24% ± 14%	Explore
type I pneumocyte	4 studies	24% ± 7%	Explore
hematopoietic stem cell	4 studies	19% ± 1%	Explore
respiratory goblet cell	4 studies	36% ± 14%	Explore
transit amplifying cell	4 studies	36% ± 25%	Explore
interneuron	4 studies	57% ± 26%	Explore
plasmacytoid dendritic cell	4 studies	24% ± 5%	Explore
pancreatic A cell	3 studies	30% ± 12%	Explore
type B pancreatic cell	3 studies	31% ± 12%	Explore
classical monocyte	3 studies	18% ± 2%	Explore
GABAergic interneuron	3 studies	29% ± 3%	Explore
brush cell	3 studies	29% ± 6%	Explore
retinal cone cell	3 studies	34% ± 4%	Explore
serous secreting cell	3 studies	31% ± 5%	Explore
mesothelial cell	3 studies	20% ± 3%	Explore
mononuclear phagocyte	3 studies	23% ± 11%	Explore
lymphocyte	3 studies	26% ± 7%	Explore
ON-bipolar cell	3 studies	28% ± 9%	Explore
glycinergic amacrine cell	3 studies	26% ± 6%	Explore
rod bipolar cell	3 studies	29% ± 9%	Explore
hepatocyte	3 studies	35% ± 14%	Explore
abnormal cell	3 studies	28% ± 9%	Explore
ependymal cell	3 studies	31% ± 17%	Explore
granulocyte monocyte progenitor cell	3 studies	33% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	41% ± 22%	Explore
enteroendocrine cell	3 studies	29% ± 7%	Explore
intestinal crypt stem cell	3 studies	29% ± 8%	Explore
leukocyte	3 studies	23% ± 4%	Explore
alveolar macrophage	3 studies	29% ± 8%	Explore
erythrocyte	3 studies	32% ± 13%	Explore
granule cell	3 studies	19% ± 3%	Explore
CD4-positive, alpha-beta T cell	3 studies	16% ± 1%	Explore
mast cell	3 studies	18% ± 1%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
brain	16 studies	35% ± 22%	Explore
lung	10 studies	24% ± 9%	Explore
eye	6 studies	31% ± 14%	Explore
heart	4 studies	20% ± 1%	Explore
liver	4 studies	33% ± 15%	Explore
pancreas	3 studies	30% ± 11%	Explore
kidney	3 studies	21% ± 3%	Explore
intestine	3 studies	23% ± 7%	Explore
adipose	3 studies	21% ± 1%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2385.25	1445 / 1445	100%	30.39	183 / 183
ovary	100%	1634.92	180 / 180	100%	29.06	430 / 430
pancreas	100%	1513.08	328 / 328	100%	33.55	178 / 178
prostate	100%	2371.39	245 / 245	100%	58.61	502 / 502
stomach	100%	2131.01	359 / 359	100%	40.33	286 / 286
uterus	100%	2017.13	170 / 170	100%	39.53	459 / 459
breast	100%	2402.24	459 / 459	100%	48.83	1117 / 1118
thymus	100%	2463.94	653 / 653	100%	42.94	604 / 605
intestine	100%	2657.94	966 / 966	100%	47.48	526 / 527
kidney	100%	3707.92	89 / 89	100%	33.01	899 / 901
lung	100%	1955.66	576 / 578	100%	37.98	1155 / 1155
bladder	100%	2052.43	21 / 21	100%	40.97	502 / 504
brain	100%	1417.38	2631 / 2642	100%	27.96	705 / 705
liver	100%	2148.02	226 / 226	100%	27.44	404 / 406
adrenal gland	100%	3314.02	258 / 258	99%	32.88	228 / 230
skin	100%	2747.98	1809 / 1809	98%	27.63	461 / 472
adipose	100%	1810.94	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	31.28	29 / 29
spleen	100%	1898.69	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	38.16	45 / 45
ureter	0%	0	0 / 0	100%	20.84	1 / 1
blood vessel	100%	1908.17	1334 / 1335	0%	0	0 / 0
muscle	100%	1499.45	801 / 803	0%	0	0 / 0
heart	98%	2318.69	840 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	26.59	75 / 80
peripheral blood	90%	1601.89	835 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0