Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 12 studies | 70% ± 23% | |
oligodendrocyte precursor cell | 12 studies | 35% ± 16% | |
GABAergic neuron | 9 studies | 64% ± 24% | |
astrocyte | 7 studies | 29% ± 17% | |
amacrine cell | 7 studies | 50% ± 20% | |
neuron | 6 studies | 48% ± 14% | |
interneuron | 6 studies | 64% ± 23% | |
retinal ganglion cell | 6 studies | 37% ± 15% | |
retina horizontal cell | 6 studies | 38% ± 16% | |
retinal bipolar neuron | 5 studies | 58% ± 31% | |
retinal cone cell | 5 studies | 24% ± 8% | |
endothelial cell | 4 studies | 42% ± 25% | |
granule cell | 4 studies | 58% ± 20% | |
retinal rod cell | 4 studies | 44% ± 10% | |
pancreatic D cell | 3 studies | 46% ± 32% | |
microglial cell | 3 studies | 39% ± 17% | |
GABAergic amacrine cell | 3 studies | 57% ± 13% | |
OFF-bipolar cell | 3 studies | 74% ± 29% | |
ON-bipolar cell | 3 studies | 71% ± 28% | |
glycinergic amacrine cell | 3 studies | 65% ± 3% | |
rod bipolar cell | 3 studies | 73% ± 28% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 96% | 4950.34 | 2530 / 2642 | 82% | 16.35 | 578 / 705 |
thymus | 90% | 939.63 | 590 / 653 | 37% | 2.76 | 226 / 605 |
prostate | 32% | 229.06 | 78 / 245 | 90% | 11.57 | 453 / 502 |
pancreas | 47% | 261.62 | 155 / 328 | 56% | 5.35 | 99 / 178 |
kidney | 63% | 405.79 | 56 / 89 | 39% | 2.86 | 354 / 901 |
stomach | 70% | 467.12 | 250 / 359 | 27% | 1.48 | 76 / 286 |
adrenal gland | 24% | 189.02 | 61 / 258 | 68% | 16.50 | 157 / 230 |
esophagus | 22% | 114.99 | 320 / 1445 | 32% | 1.85 | 58 / 183 |
heart | 48% | 655.30 | 417 / 861 | 0% | 0 | 0 / 0 |
bladder | 29% | 233.48 | 6 / 21 | 18% | 0.86 | 93 / 504 |
ovary | 26% | 122.60 | 46 / 180 | 12% | 0.45 | 52 / 430 |
lung | 10% | 53.49 | 59 / 578 | 27% | 1.66 | 313 / 1155 |
intestine | 19% | 88.62 | 179 / 966 | 17% | 0.91 | 92 / 527 |
eye | 0% | 0 | 0 / 0 | 35% | 3.07 | 28 / 80 |
skin | 9% | 42.99 | 158 / 1809 | 25% | 1.89 | 116 / 472 |
uterus | 19% | 97.56 | 33 / 170 | 12% | 0.69 | 56 / 459 |
breast | 2% | 8.85 | 8 / 459 | 24% | 1.75 | 263 / 1118 |
liver | 10% | 65.19 | 23 / 226 | 15% | 1.45 | 60 / 406 |
tonsil | 0% | 0 | 0 / 0 | 2% | 0.05 | 1 / 45 |
spleen | 1% | 7.39 | 3 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 1% | 4.77 | 11 / 1335 | 0% | 0 | 0 / 0 |
adipose | 0% | 2.33 | 6 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0.46 | 1 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0071420 | Biological process | cellular response to histamine |
GO_0042391 | Biological process | regulation of membrane potential |
GO_0007165 | Biological process | signal transduction |
GO_1904862 | Biological process | inhibitory synapse assembly |
GO_0060021 | Biological process | roof of mouth development |
GO_1902476 | Biological process | chloride transmembrane transport |
GO_0007268 | Biological process | chemical synaptic transmission |
GO_0051932 | Biological process | synaptic transmission, GABAergic |
GO_0007214 | Biological process | gamma-aminobutyric acid signaling pathway |
GO_0005886 | Cellular component | plasma membrane |
GO_1902495 | Cellular component | transmembrane transporter complex |
GO_0043005 | Cellular component | neuron projection |
GO_0034707 | Cellular component | chloride channel complex |
GO_0045202 | Cellular component | synapse |
GO_1902711 | Cellular component | GABA-A receptor complex |
GO_0099634 | Cellular component | postsynaptic specialization membrane |
GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
GO_0004890 | Molecular function | GABA-A receptor activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0030594 | Molecular function | neurotransmitter receptor activity |
GO_0022851 | Molecular function | GABA-gated chloride ion channel activity |
GO_0005254 | Molecular function | chloride channel activity |
Gene name | GABRB3 |
Protein name | Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3) Alternative protein GABRB3 Gamma-aminobutyric acid type A receptor subunit beta3 Gamma-aminobutyric acid A receptor beta 3 isoform A Gamma-aminobutyric acid type A receptor beta3 subunit |
Synonyms | |
Description | FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity . The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine . Plays an important role in somatosensation and in the production of antinociception (By similarity). . |
Accessions | A0A1B0GU30 G3V373 ENST00000555632.5 ENST00000541819.6 ENST00000635994.1 ENST00000556636.5 ENST00000545868.4 [P28472-4] ENST00000400188.7 [P28472-3] G3V4W7 H0YJU6 ENST00000638099.1 A0A1B0GVW3 A0A193AUE8 L8E9G0 X5DQY4 F5H7N0 ENST00000299267.9 [P28472-2] ENST00000554556.5 ENST00000311550.10 [P28472-1] P28472 ENST00000636466.1 [P28472-4] |