GABRB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071420Biological processcellular response to histamine
GO_0042391Biological processregulation of membrane potential
GO_0007165Biological processsignal transduction
GO_1904862Biological processinhibitory synapse assembly
GO_0060021Biological processroof of mouth development
GO_1902476Biological processchloride transmembrane transport
GO_0007268Biological processchemical synaptic transmission
GO_0051932Biological processsynaptic transmission, GABAergic
GO_0007214Biological processgamma-aminobutyric acid signaling pathway
GO_0005886Cellular componentplasma membrane
GO_1902495Cellular componenttransmembrane transporter complex
GO_0043005Cellular componentneuron projection
GO_0034707Cellular componentchloride channel complex
GO_0045202Cellular componentsynapse
GO_1902711Cellular componentGABA-A receptor complex
GO_0099634Cellular componentpostsynaptic specialization membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0004890Molecular functionGABA-A receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0022851Molecular functionGABA-gated chloride ion channel activity
GO_0005254Molecular functionchloride channel activity

IV. Literature review

[source]
Gene nameGABRB3
Protein nameGamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3)
Alternative protein GABRB3
Gamma-aminobutyric acid type A receptor subunit beta3
Gamma-aminobutyric acid A receptor beta 3 isoform A
Gamma-aminobutyric acid type A receptor beta3 subunit
Synonyms
DescriptionFUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta3/gamma2 receptor exhibits synaptogenic activity . The alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine . Plays an important role in somatosensation and in the production of antinociception (By similarity). .

AccessionsA0A1B0GU30
G3V373
ENST00000555632.5
ENST00000541819.6
ENST00000635994.1
ENST00000556636.5
ENST00000545868.4 [P28472-4]
ENST00000400188.7 [P28472-3]
G3V4W7
H0YJU6
ENST00000638099.1
A0A1B0GVW3
A0A193AUE8
L8E9G0
X5DQY4
F5H7N0
ENST00000299267.9 [P28472-2]
ENST00000554556.5
ENST00000311550.10 [P28472-1]
P28472
ENST00000636466.1 [P28472-4]