RELB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0033554Biological processcellular response to stress
GO_0045063Biological processT-helper 1 cell differentiation
GO_0045087Biological processinnate immune response
GO_0034097Biological processresponse to cytokine
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0032922Biological processcircadian regulation of gene expression
GO_0071470Biological processcellular response to osmotic stress
GO_0043011Biological processmyeloid dendritic cell differentiation
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0019882Biological processantigen processing and presentation
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030098Biological processlymphocyte differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0071159Cellular componentNF-kappaB complex
GO_0005829Cellular componentcytosol
GO_0045202Cellular componentsynapse
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0019901Molecular functionprotein kinase binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRELB
Protein nameRELB proto-oncogene, NF-kB subunit (V-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (Avian))
RELB proto-oncogene, NF-kB subunit
Transcription factor RelB (I-Rel)
SynonymshCG_22137
DescriptionFUNCTION: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function . .

AccessionsQ01201
ENST00000700471.1
A0A8V8TQY2
D6RIV7
K7ERX9
ENST00000589972.1
ENST00000509480.5
ENST00000221452.13
D6R992
ENST00000505236.2