NQO1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
ciliated cell	13 studies	53% ± 13%	Explore
endothelial cell	11 studies	25% ± 6%	Explore
epithelial cell	10 studies	36% ± 12%	Explore
basal cell	6 studies	35% ± 21%	Explore
goblet cell	6 studies	28% ± 8%	Explore
endothelial cell of vascular tree	6 studies	24% ± 6%	Explore
respiratory goblet cell	5 studies	34% ± 5%	Explore
secretory cell	5 studies	28% ± 8%	Explore
endothelial cell of artery	5 studies	19% ± 1%	Explore
deuterosomal cell	4 studies	45% ± 6%	Explore
vein endothelial cell	4 studies	23% ± 5%	Explore
abnormal cell	4 studies	28% ± 3%	Explore
brush cell	4 studies	29% ± 16%	Explore
kidney loop of Henle epithelial cell	3 studies	24% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	3 studies	34% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	95%	10483.31	340 / 359	95%	200.77	271 / 286
bladder	100%	3758.29	21 / 21	88%	216.78	445 / 504
esophagus	95%	3682.81	1379 / 1445	91%	219.01	167 / 183
breast	98%	3787.63	451 / 459	88%	176.80	986 / 1118
intestine	86%	2371.89	830 / 966	93%	218.84	488 / 527
thymus	99%	6416.19	647 / 653	72%	110.13	433 / 605
lung	87%	1881.08	502 / 578	83%	267.27	961 / 1155
kidney	99%	4218.33	88 / 89	44%	61.63	398 / 901
adrenal gland	100%	4637.20	257 / 258	27%	34.06	62 / 230
uterus	50%	549.03	85 / 170	75%	140.04	346 / 459
skin	47%	5453.18	848 / 1809	68%	104.15	321 / 472
ureter	0%	0	0 / 0	100%	148.41	1 / 1
brain	81%	1757.18	2138 / 2642	19%	11.23	131 / 705
adipose	99%	4955.00	1192 / 1204	0%	0	0 / 0
pancreas	7%	60.93	24 / 328	91%	223.95	162 / 178
prostate	65%	893.51	160 / 245	32%	20.82	163 / 502
blood vessel	94%	1952.38	1257 / 1335	0%	0	0 / 0
ovary	17%	220.50	30 / 180	58%	48.23	250 / 430
spleen	73%	1040.22	175 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	56%	95.78	25 / 45
eye	0%	0	0 / 0	53%	57.20	42 / 80
muscle	48%	781.41	386 / 803	0%	0	0 / 0
liver	5%	52.83	11 / 226	42%	154.74	172 / 406
heart	44%	552.77	376 / 861	0%	0	0 / 0
peripheral blood	17%	275.76	158 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	3.16	2 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007584	Biological process	response to nutrient
GO_0045454	Biological process	cell redox homeostasis
GO_0042177	Biological process	negative regulation of protein catabolic process
GO_0032355	Biological process	response to estradiol
GO_0033574	Biological process	response to testosterone
GO_0014075	Biological process	response to amine
GO_0006805	Biological process	xenobiotic metabolic process
GO_0002931	Biological process	response to ischemia
GO_0000209	Biological process	protein polyubiquitination
GO_1904844	Biological process	response to L-glutamine
GO_0051602	Biological process	response to electrical stimulus
GO_0045087	Biological process	innate immune response
GO_1905395	Biological process	response to flavonoid
GO_0110076	Biological process	negative regulation of ferroptosis
GO_0043279	Biological process	response to alkaloid
GO_1904880	Biological process	response to hydrogen sulfide
GO_0042360	Biological process	vitamin E metabolic process
GO_0045471	Biological process	response to ethanol
GO_1904772	Biological process	response to tetrachloromethane
GO_0043525	Biological process	positive regulation of neuron apoptotic process
GO_0006116	Biological process	NADH oxidation
GO_0042373	Biological process	vitamin K metabolic process
GO_0009725	Biological process	response to hormone
GO_0034599	Biological process	cellular response to oxidative stress
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0006809	Biological process	nitric oxide biosynthetic process
GO_0009743	Biological process	response to carbohydrate
GO_0071248	Biological process	cellular response to metal ion
GO_0030163	Biological process	protein catabolic process
GO_0070995	Biological process	NADPH oxidation
GO_0009636	Biological process	response to toxic substance
GO_0019430	Biological process	removal of superoxide radicals
GO_0006743	Biological process	ubiquinone metabolic process
GO_0006979	Biological process	response to oxidative stress
GO_0007271	Biological process	synaptic transmission, cholinergic
GO_0070301	Biological process	cellular response to hydrogen peroxide
GO_0032496	Biological process	response to lipopolysaccharide
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0008753	Molecular function	NADPH dehydrogenase (quinone) activity
GO_0050136	Molecular function	NADH:ubiquinone reductase (non-electrogenic) activity
GO_0004128	Molecular function	cytochrome-b5 reductase activity, acting on NAD(P)H
GO_0003955	Molecular function	NAD(P)H dehydrogenase (quinone) activity
GO_0004784	Molecular function	superoxide dismutase activity
GO_0042802	Molecular function	identical protein binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NQO1
Protein name	NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) Alternative protein NQO1
Synonyms	hCG_28204 NMOR1 DIA4
Description	FUNCTION: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion . Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential . Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome . .
Accessions	ENST00000379046.6 [P15559-3] H3BRK3 P15559 Q3B792 L8E9G5 ENST00000439109.6 H3BNV2 L8EC59 ENST00000379047.7 [P15559-2] ENST00000564043.1 ENST00000561500.5 B4DLR8 ENST00000320623.10 [P15559-1]

NQO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review