PGRMC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	32 studies	39% ± 15%	Explore
endothelial cell	30 studies	26% ± 12%	Explore
pericyte	21 studies	27% ± 9%	Explore
smooth muscle cell	18 studies	38% ± 19%	Explore
ciliated cell	16 studies	40% ± 17%	Explore
connective tissue cell	15 studies	45% ± 16%	Explore
epithelial cell	15 studies	42% ± 24%	Explore
myofibroblast cell	13 studies	40% ± 16%	Explore
basal cell	11 studies	31% ± 16%	Explore
capillary endothelial cell	10 studies	21% ± 6%	Explore
oligodendrocyte	10 studies	28% ± 12%	Explore
endothelial cell of artery	10 studies	20% ± 5%	Explore
endothelial cell of lymphatic vessel	9 studies	24% ± 6%	Explore
platelet	9 studies	60% ± 11%	Explore
endothelial cell of vascular tree	9 studies	21% ± 3%	Explore
oligodendrocyte precursor cell	9 studies	40% ± 15%	Explore
type I pneumocyte	8 studies	30% ± 11%	Explore
neuron	8 studies	51% ± 17%	Explore
vein endothelial cell	8 studies	22% ± 5%	Explore
GABAergic neuron	8 studies	35% ± 16%	Explore
glutamatergic neuron	8 studies	38% ± 13%	Explore
secretory cell	7 studies	24% ± 7%	Explore
epithelial cell of proximal tubule	7 studies	44% ± 15%	Explore
abnormal cell	7 studies	42% ± 17%	Explore
mesothelial cell	7 studies	53% ± 20%	Explore
kidney loop of Henle epithelial cell	6 studies	32% ± 14%	Explore
enterocyte	6 studies	35% ± 8%	Explore
type II pneumocyte	6 studies	28% ± 14%	Explore
progenitor cell	5 studies	44% ± 16%	Explore
intestinal crypt stem cell	5 studies	23% ± 6%	Explore
transit amplifying cell	5 studies	19% ± 1%	Explore
amacrine cell	5 studies	44% ± 20%	Explore
interneuron	5 studies	41% ± 17%	Explore
pancreatic A cell	4 studies	35% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	53% ± 9%	Explore
renal alpha-intercalated cell	4 studies	43% ± 11%	Explore
enteroendocrine cell	4 studies	32% ± 11%	Explore
OFF-bipolar cell	4 studies	34% ± 13%	Explore
ON-bipolar cell	4 studies	34% ± 14%	Explore
retinal ganglion cell	4 studies	66% ± 24%	Explore
retina horizontal cell	4 studies	33% ± 13%	Explore
adventitial cell	4 studies	30% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	36% ± 10%	Explore
hepatocyte	4 studies	49% ± 29%	Explore
duct epithelial cell	3 studies	17% ± 2%	Explore
ionocyte	3 studies	20% ± 2%	Explore
respiratory goblet cell	3 studies	29% ± 18%	Explore
pancreatic D cell	3 studies	42% ± 21%	Explore
type B pancreatic cell	3 studies	48% ± 12%	Explore
conventional dendritic cell	3 studies	26% ± 2%	Explore
non-classical monocyte	3 studies	23% ± 6%	Explore
goblet cell	3 studies	29% ± 9%	Explore
neural crest cell	3 studies	45% ± 16%	Explore
retinal bipolar neuron	3 studies	53% ± 13%	Explore
GABAergic amacrine cell	3 studies	36% ± 11%	Explore
glycinergic amacrine cell	3 studies	26% ± 8%	Explore
megakaryocyte	3 studies	49% ± 14%	Explore
club cell	3 studies	40% ± 11%	Explore
astrocyte	3 studies	27% ± 12%	Explore
retinal cone cell	3 studies	64% ± 15%	Explore
retinal rod cell	3 studies	31% ± 9%	Explore
Mueller cell	3 studies	27% ± 8%	Explore
rod bipolar cell	3 studies	39% ± 13%	Explore
myoepithelial cell	3 studies	44% ± 11%	Explore
dendritic cell	3 studies	28% ± 5%	Explore
pancreatic ductal cell	3 studies	46% ± 16%	Explore
glial cell	3 studies	46% ± 25%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	30% ± 12%	Explore
lung	10 studies	27% ± 12%	Explore
intestine	8 studies	32% ± 15%	Explore
kidney	7 studies	29% ± 9%	Explore
eye	7 studies	32% ± 12%	Explore
breast	4 studies	23% ± 2%	Explore
liver	4 studies	25% ± 5%	Explore
pancreas	3 studies	44% ± 10%	Explore
uterus	3 studies	44% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	8926.63	459 / 459	100%	314.52	1117 / 1118
prostate	100%	7514.08	245 / 245	100%	220.26	501 / 502
uterus	100%	7796.69	170 / 170	100%	289.02	458 / 459
stomach	100%	4481.64	359 / 359	100%	260.64	285 / 286
ovary	100%	6217.08	180 / 180	100%	271.83	428 / 430
brain	100%	8441.40	2632 / 2642	100%	281.65	704 / 705
esophagus	100%	5100.90	1445 / 1445	99%	197.63	182 / 183
kidney	100%	6909.35	89 / 89	99%	419.87	896 / 901
intestine	100%	6956.22	966 / 966	99%	285.39	524 / 527
bladder	100%	6824.48	21 / 21	99%	270.42	501 / 504
lung	99%	5064.29	574 / 578	100%	249.40	1155 / 1155
adrenal gland	100%	14669.38	258 / 258	99%	441.41	228 / 230
liver	100%	14348.00	226 / 226	99%	526.09	402 / 406
thymus	100%	5608.60	652 / 653	99%	267.20	597 / 605
skin	100%	5910.67	1801 / 1809	92%	164.48	432 / 472
pancreas	88%	1824.17	289 / 328	98%	200.77	175 / 178
adipose	100%	8509.61	1204 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	181.92	45 / 45
ureter	0%	0	0 / 0	100%	118.21	1 / 1
blood vessel	100%	7476.30	1333 / 1335	0%	0	0 / 0
spleen	98%	2659.24	237 / 241	0%	0	0 / 0
heart	74%	1677.97	639 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	63%	65.36	50 / 80
lymph node	0%	0	0 / 0	59%	41.29	17 / 29
peripheral blood	46%	966.94	423 / 929	0%	0	0 / 0
muscle	17%	283.24	133 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006783	Biological process	heme biosynthetic process
GO_1903078	Biological process	positive regulation of protein localization to plasma membrane
GO_0140077	Biological process	positive regulation of lipoprotein transport
GO_0005576	Cellular component	extracellular region
GO_0035579	Cellular component	specific granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0012505	Cellular component	endomembrane system
GO_0016020	Cellular component	membrane
GO_0043025	Cellular component	neuronal cell body
GO_0043005	Cellular component	neuron projection
GO_0030868	Cellular component	smooth endoplasmic reticulum membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0045202	Cellular component	synapse
GO_0044297	Cellular component	cell body
GO_0005741	Cellular component	mitochondrial outer membrane
GO_0042803	Molecular function	protein homodimerization activity
GO_0001540	Molecular function	amyloid-beta binding
GO_0020037	Molecular function	heme binding
GO_0005496	Molecular function	steroid binding
GO_0046872	Molecular function	metal ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PGRMC1
Protein name	Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA) Membrane-associated progesterone receptor component 1
Synonyms	hCG_23188 HPR6.6 PGRMC
Description	FUNCTION: Component of a progesterone-binding protein complex . Binds progesterone . Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins . Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization . .
Accessions	O00264 ENST00000535419.2 [O00264-2] Q6IB11 ENST00000217971.8 [O00264-1]

PGRMC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review