Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 12 studies | 34% ± 13% | |
glutamatergic neuron | 11 studies | 68% ± 24% | |
endothelial cell | 10 studies | 31% ± 20% | |
oligodendrocyte precursor cell | 10 studies | 49% ± 22% | |
neuron | 8 studies | 52% ± 21% | |
GABAergic neuron | 8 studies | 73% ± 21% | |
astrocyte | 6 studies | 47% ± 32% | |
retinal ganglion cell | 6 studies | 63% ± 15% | |
interneuron | 5 studies | 78% ± 17% | |
epithelial cell | 4 studies | 30% ± 9% | |
granule cell | 4 studies | 54% ± 23% | |
microglial cell | 4 studies | 43% ± 28% | |
amacrine cell | 4 studies | 31% ± 6% | |
goblet cell | 4 studies | 53% ± 31% | |
oligodendrocyte | 4 studies | 41% ± 30% | |
glomerular endothelial cell | 3 studies | 18% ± 1% | |
GABAergic amacrine cell | 3 studies | 48% ± 8% | |
glycinergic amacrine cell | 3 studies | 24% ± 4% | |
enteroendocrine cell | 3 studies | 49% ± 24% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 8655.06 | 2641 / 2642 | 100% | 85.34 | 702 / 705 |
prostate | 92% | 1824.22 | 225 / 245 | 98% | 140.81 | 492 / 502 |
pancreas | 99% | 3480.68 | 326 / 328 | 89% | 67.64 | 159 / 178 |
thymus | 95% | 1419.24 | 622 / 653 | 85% | 21.80 | 515 / 605 |
stomach | 92% | 2923.14 | 332 / 359 | 75% | 29.91 | 215 / 286 |
intestine | 84% | 913.61 | 810 / 966 | 77% | 32.50 | 407 / 527 |
kidney | 72% | 712.94 | 64 / 89 | 50% | 9.09 | 450 / 901 |
adrenal gland | 34% | 586.88 | 88 / 258 | 75% | 214.50 | 172 / 230 |
spleen | 100% | 2445.19 | 241 / 241 | 0% | 0 | 0 / 0 |
lung | 69% | 705.88 | 399 / 578 | 30% | 9.61 | 343 / 1155 |
ovary | 94% | 1290.19 | 169 / 180 | 4% | 0.77 | 16 / 430 |
breast | 60% | 554.60 | 274 / 459 | 32% | 19.96 | 362 / 1118 |
bladder | 43% | 553.05 | 9 / 21 | 27% | 9.48 | 134 / 504 |
adipose | 69% | 659.65 | 829 / 1204 | 0% | 0 | 0 / 0 |
esophagus | 20% | 171.70 | 282 / 1445 | 32% | 11.93 | 58 / 183 |
uterus | 27% | 313.36 | 46 / 170 | 8% | 1.43 | 36 / 459 |
lymph node | 0% | 0 | 0 / 0 | 28% | 5.37 | 8 / 29 |
eye | 0% | 0 | 0 / 0 | 23% | 3.75 | 18 / 80 |
heart | 19% | 158.68 | 167 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 14% | 134.51 | 132 / 929 | 0% | 0 | 0 / 0 |
blood vessel | 7% | 62.32 | 98 / 1335 | 0% | 0 | 0 / 0 |
liver | 0% | 2.99 | 1 / 226 | 5% | 1.88 | 21 / 406 |
skin | 1% | 10.15 | 18 / 1809 | 4% | 0.91 | 18 / 472 |
tonsil | 0% | 0 | 0 / 0 | 2% | 0.74 | 1 / 45 |
muscle | 0% | 1.04 | 1 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006470 | Biological process | protein dephosphorylation |
GO_0006629 | Biological process | lipid metabolic process |
GO_0051046 | Biological process | regulation of secretion |
GO_0035773 | Biological process | insulin secretion involved in cellular response to glucose stimulus |
GO_0007269 | Biological process | neurotransmitter secretion |
GO_0030141 | Cellular component | secretory granule |
GO_0030667 | Cellular component | secretory granule membrane |
GO_0030672 | Cellular component | synaptic vesicle membrane |
GO_0043235 | Cellular component | receptor complex |
GO_0045202 | Cellular component | synapse |
GO_0005886 | Cellular component | plasma membrane |
GO_0101003 | Cellular component | ficolin-1-rich granule membrane |
GO_0005001 | Molecular function | transmembrane receptor protein tyrosine phosphatase activity |
Gene name | PTPRN2 |
Protein name | Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60] Receptor-type tyrosine-protein phosphatase N2 Protein tyrosine phosphatase receptor type N2 PTPRN2 protein |
Synonyms | KIAA0387 |
Description | FUNCTION: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments . . |
Accessions | ENST00000633393.1 ENST00000409483.5 ENST00000633583.1 E7EM83 A0A0J9YWV3 ENST00000389413.7 [Q92932-2] A0A3B3IU41 ENST00000648371.1 ENST00000631503.1 I6L9F8 ENST00000389416.8 [Q92932-4] ENST00000389418.9 [Q92932-1] Q92932 |