PTPRN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0006629Biological processlipid metabolic process
GO_0051046Biological processregulation of secretion
GO_0035773Biological processinsulin secretion involved in cellular response to glucose stimulus
GO_0007269Biological processneurotransmitter secretion
GO_0030141Cellular componentsecretory granule
GO_0030667Cellular componentsecretory granule membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0043235Cellular componentreceptor complex
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0005001Molecular functiontransmembrane receptor protein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPRN2
Protein nameReceptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]
Receptor-type tyrosine-protein phosphatase N2
Protein tyrosine phosphatase receptor type N2
PTPRN2 protein
SynonymsKIAA0387
DescriptionFUNCTION: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments . .

AccessionsENST00000633393.1
ENST00000409483.5
ENST00000633583.1
E7EM83
A0A0J9YWV3
ENST00000389413.7 [Q92932-2]
A0A3B3IU41
ENST00000648371.1
ENST00000631503.1
I6L9F8
ENST00000389416.8 [Q92932-4]
ENST00000389418.9 [Q92932-1]
Q92932