Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 12 studies | 48% ± 24% | |
| GABAergic neuron | 9 studies | 44% ± 23% | |
| retinal bipolar neuron | 5 studies | 38% ± 16% | |
| OFF-bipolar cell | 4 studies | 31% ± 12% | |
| interneuron | 4 studies | 59% ± 24% | |
| neuron | 3 studies | 38% ± 18% | |
| ON-bipolar cell | 3 studies | 36% ± 6% | |
| rod bipolar cell | 3 studies | 52% ± 6% | |
| granule cell | 3 studies | 32% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 9 studies | 39% ± 26% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 85% | 5172.88 | 2240 / 2642 | 65% | 10.40 | 458 / 705 |
| adrenal gland | 2% | 15.71 | 4 / 258 | 26% | 1.76 | 59 / 230 |
| thymus | 0% | 0 | 0 / 653 | 5% | 0.18 | 29 / 605 |
| prostate | 0% | 2.42 | 1 / 245 | 4% | 0.33 | 18 / 502 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.18 | 2 / 80 |
| pancreas | 0% | 0 | 0 / 328 | 1% | 0.03 | 2 / 178 |
| breast | 0% | 0 | 0 / 459 | 1% | 0.56 | 12 / 1118 |
| uterus | 0% | 0 | 0 / 170 | 1% | 0.01 | 4 / 459 |
| lung | 0% | 0 | 0 / 578 | 1% | 0.02 | 10 / 1155 |
| esophagus | 0% | 0 | 0 / 1445 | 1% | 0.01 | 1 / 183 |
| ovary | 0% | 0 | 0 / 180 | 0% | 0.01 | 2 / 430 |
| bladder | 0% | 0 | 0 / 21 | 0% | 0.01 | 2 / 504 |
| stomach | 0% | 0 | 0 / 359 | 0% | 0.01 | 1 / 286 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0.00 | 2 / 901 |
| skin | 0% | 0 | 0 / 1809 | 0% | 0.00 | 1 / 472 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0 | 0 / 1335 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| heart | 0% | 0 | 0 / 861 | 0% | 0 | 0 / 0 |
| intestine | 0% | 0 | 0 / 966 | 0% | 0 | 0 / 527 |
| liver | 0% | 0 | 0 / 226 | 0% | 0 | 0 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1904862 | Biological process | inhibitory synapse assembly |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0060078 | Biological process | regulation of postsynaptic membrane potential |
| GO_0051932 | Biological process | synaptic transmission, GABAergic |
| GO_0007214 | Biological process | gamma-aminobutyric acid signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_1902710 | Cellular component | GABA receptor complex |
| GO_1902495 | Cellular component | transmembrane transporter complex |
| GO_0098794 | Cellular component | postsynapse |
| GO_0043005 | Cellular component | neuron projection |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0034707 | Cellular component | chloride channel complex |
| GO_0045202 | Cellular component | synapse |
| GO_1902711 | Cellular component | GABA-A receptor complex |
| GO_0099634 | Cellular component | postsynaptic specialization membrane |
| GO_0030659 | Cellular component | cytoplasmic vesicle membrane |
| GO_0032590 | Cellular component | dendrite membrane |
| GO_0016917 | Molecular function | GABA receptor activity |
| GO_1904315 | Molecular function | transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| GO_0004890 | Molecular function | GABA-A receptor activity |
| GO_0005254 | Molecular function | chloride channel activity |
| GO_0022851 | Molecular function | GABA-gated chloride ion channel activity |
| GO_0008503 | Molecular function | benzodiazepine receptor activity |
| Gene name | GABRA1 |
| Protein name | Gamma-aminobutyric acid type A receptor subunit alpha1 Gamma-aminobutyric acid receptor subunit alpha-1 (GABA(A) receptor subunit alpha-1) |
| Synonyms | |
| Description | FUNCTION: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain . Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel . The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity . GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity). Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). . |
| Accessions | A0A0U1RRB2 ENST00000638112.1 ENST00000521339.5 ENST00000636340.1 E5RHL6 P14867 ENST00000437025.6 ENST00000638159.1 ENST00000637827.1 ENST00000635096.1 E5RJS3 ENST00000519621.2 A0A1B0GU82 ENST00000634335.1 ENST00000393943.10 A0A1B0GVW9 A0A1B0GV38 ENST00000522651.6 ENST00000428797.7 ENST00000637044.1 ENST00000023897.10 E5RK60 ENST00000635880.1 ENST00000636573.1 A0A0U1RQJ3 |
