ATP1A3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	7 studies	44% ± 18%	Explore
amacrine cell	7 studies	43% ± 18%	Explore
retinal ganglion cell	7 studies	65% ± 33%	Explore
retinal rod cell	7 studies	38% ± 13%	Explore
neuron	6 studies	37% ± 15%	Explore
GABAergic neuron	5 studies	55% ± 22%	Explore
interneuron	5 studies	55% ± 23%	Explore
retina horizontal cell	5 studies	47% ± 17%	Explore
retinal bipolar neuron	4 studies	58% ± 18%	Explore
OFF-bipolar cell	4 studies	62% ± 21%	Explore
ON-bipolar cell	4 studies	60% ± 24%	Explore
retinal cone cell	4 studies	51% ± 19%	Explore
GABAergic interneuron	3 studies	39% ± 6%	Explore
GABAergic amacrine cell	3 studies	42% ± 15%	Explore
glycinergic amacrine cell	3 studies	37% ± 15%	Explore
rod bipolar cell	3 studies	60% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	31% ± 19%	Explore
eye	8 studies	37% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	93%	28106.45	2448 / 2642	94%	12.67	664 / 705
heart	93%	15135.71	798 / 861	0%	0	0 / 0
adrenal gland	10%	460.78	26 / 258	79%	37.70	181 / 230
lymph node	0%	0	0 / 0	28%	0.46	8 / 29
ovary	0%	0	0 / 180	15%	0.46	63 / 430
eye	0%	0	0 / 0	10%	0.75	8 / 80
thymus	0%	6.06	1 / 653	9%	0.27	56 / 605
intestine	2%	40.21	16 / 966	8%	0.27	40 / 527
stomach	0%	6.20	1 / 359	8%	0.23	22 / 286
skin	0%	3.49	2 / 1809	6%	0.13	26 / 472
pancreas	0%	0	0 / 328	6%	0.32	10 / 178
esophagus	1%	12.76	8 / 1445	5%	0.09	9 / 183
uterus	0%	0	0 / 170	5%	0.29	25 / 459
breast	0%	0	0 / 459	5%	0.14	57 / 1118
bladder	0%	0	0 / 21	5%	0.12	23 / 504
tonsil	0%	0	0 / 0	4%	0.06	2 / 45
kidney	0%	0	0 / 89	4%	0.56	40 / 901
lung	0%	12.61	1 / 578	3%	0.08	38 / 1155
liver	0%	0	0 / 226	1%	0.04	6 / 406
blood vessel	1%	27.30	8 / 1335	0%	0	0 / 0
peripheral blood	0%	5.82	2 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
adipose	0%	0	0 / 1204	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
prostate	0%	0	0 / 245	0%	0	0 / 502
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0036376	Biological process	sodium ion export across plasma membrane
GO_0086064	Biological process	cell communication by electrical coupling involved in cardiac conduction
GO_0071383	Biological process	cellular response to steroid hormone stimulus
GO_1990535	Biological process	neuron projection maintenance
GO_0006883	Biological process	intracellular sodium ion homeostasis
GO_1903416	Biological process	response to glycoside
GO_0010248	Biological process	establishment or maintenance of transmembrane electrochemical gradient
GO_0030007	Biological process	intracellular potassium ion homeostasis
GO_1904646	Biological process	cellular response to amyloid-beta
GO_0060075	Biological process	regulation of resting membrane potential
GO_1902600	Biological process	proton transmembrane transport
GO_1990573	Biological process	potassium ion import across plasma membrane
GO_0005890	Cellular component	sodium:potassium-exchanging ATPase complex
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_1903561	Cellular component	extracellular vesicle
GO_0001917	Cellular component	photoreceptor inner segment
GO_0005794	Cellular component	Golgi apparatus
GO_0043025	Cellular component	neuronal cell body
GO_0032809	Cellular component	neuronal cell body membrane
GO_0098984	Cellular component	neuron to neuron synapse
GO_0005783	Cellular component	endoplasmic reticulum
GO_0045202	Cellular component	synapse
GO_0060342	Cellular component	photoreceptor inner segment membrane
GO_0030424	Cellular component	axon
GO_0031090	Cellular component	organelle membrane
GO_1990239	Molecular function	steroid hormone binding
GO_0001540	Molecular function	amyloid-beta binding
GO_0005391	Molecular function	P-type sodium:potassium-exchanging transporter activity
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ATP1A3
Protein name	ATPase Na+/K+ transporting subunit alpha 3 Na+/K+ transporting ATPase alpha 3 polypeptide Sodium/potassium-transporting ATPase subunit alpha Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3)
Synonyms
Description	FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. .
Accessions	A0A0A0MT26 P13637 M0R116 Q58I21 M0QXF2 ENST00000543770.5 [P13637-2] ENST00000648268.1 [P13637-1] ENST00000602133.5 ENST00000473086.3 ENST00000545399.6 [P13637-3] ENST00000441343.5

ATP1A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review