ACTB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	53 studies	83% ± 25%	Explore
B cell	52 studies	84% ± 23%	Explore
endothelial cell	52 studies	78% ± 22%	Explore
natural killer cell	49 studies	90% ± 14%	Explore
fibroblast	48 studies	78% ± 26%	Explore
T cell	44 studies	85% ± 21%	Explore
CD8-positive, alpha-beta T cell	42 studies	90% ± 17%	Explore
pericyte	41 studies	83% ± 24%	Explore
CD4-positive, alpha-beta T cell	37 studies	87% ± 22%	Explore
smooth muscle cell	35 studies	81% ± 24%	Explore
conventional dendritic cell	34 studies	96% ± 13%	Explore
plasmacytoid dendritic cell	34 studies	92% ± 17%	Explore
dendritic cell	32 studies	91% ± 15%	Explore
endothelial cell of lymphatic vessel	29 studies	82% ± 25%	Explore
classical monocyte	29 studies	95% ± 12%	Explore
regulatory T cell	29 studies	96% ± 7%	Explore
mast cell	28 studies	80% ± 24%	Explore
monocyte	28 studies	89% ± 19%	Explore
non-classical monocyte	27 studies	96% ± 11%	Explore
epithelial cell	27 studies	86% ± 21%	Explore
plasma cell	26 studies	72% ± 24%	Explore
mature NK T cell	24 studies	91% ± 12%	Explore
basal cell	23 studies	83% ± 22%	Explore
gamma-delta T cell	21 studies	92% ± 15%	Explore
memory B cell	21 studies	96% ± 6%	Explore
astrocyte	21 studies	51% ± 21%	Explore
microglial cell	21 studies	62% ± 26%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	20 studies	86% ± 21%	Explore
neutrophil	20 studies	85% ± 20%	Explore
connective tissue cell	20 studies	86% ± 19%	Explore
naive B cell	19 studies	94% ± 8%	Explore
ciliated cell	18 studies	79% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	18 studies	83% ± 27%	Explore
mucosal invariant T cell	18 studies	90% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	17 studies	92% ± 18%	Explore
oligodendrocyte	17 studies	49% ± 17%	Explore
oligodendrocyte precursor cell	17 studies	50% ± 23%	Explore
capillary endothelial cell	17 studies	87% ± 12%	Explore
myeloid cell	17 studies	76% ± 31%	Explore
endothelial cell of artery	16 studies	90% ± 8%	Explore
myofibroblast cell	16 studies	94% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	92% ± 16%	Explore
vein endothelial cell	15 studies	86% ± 14%	Explore
endothelial cell of vascular tree	15 studies	81% ± 26%	Explore
innate lymphoid cell	14 studies	94% ± 7%	Explore
erythrocyte	14 studies	74% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	79% ± 26%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	92% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	93% ± 12%	Explore
mesothelial cell	13 studies	78% ± 29%	Explore
plasmablast	12 studies	90% ± 10%	Explore
secretory cell	12 studies	91% ± 12%	Explore
leukocyte	12 studies	88% ± 11%	Explore
glutamatergic neuron	12 studies	62% ± 16%	Explore
progenitor cell	12 studies	83% ± 28%	Explore
type I pneumocyte	11 studies	87% ± 17%	Explore
platelet	11 studies	91% ± 15%	Explore
club cell	11 studies	80% ± 26%	Explore
neuron	11 studies	70% ± 24%	Explore
goblet cell	11 studies	82% ± 19%	Explore
type II pneumocyte	10 studies	76% ± 26%	Explore
T follicular helper cell	10 studies	98% ± 2%	Explore
GABAergic neuron	10 studies	49% ± 16%	Explore
abnormal cell	10 studies	85% ± 24%	Explore
IgG plasma cell	10 studies	59% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	96% ± 7%	Explore
interneuron	9 studies	57% ± 22%	Explore
enterocyte	9 studies	79% ± 28%	Explore
IgA plasma cell	9 studies	53% ± 22%	Explore
hematopoietic stem cell	9 studies	98% ± 3%	Explore
alveolar macrophage	8 studies	78% ± 28%	Explore
mononuclear phagocyte	8 studies	85% ± 23%	Explore
brush cell	8 studies	74% ± 25%	Explore
ionocyte	7 studies	89% ± 13%	Explore
respiratory goblet cell	7 studies	84% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	92% ± 12%	Explore
epithelial cell of proximal tubule	7 studies	76% ± 17%	Explore
glial cell	7 studies	72% ± 30%	Explore
CD4-positive helper T cell	6 studies	89% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	83% ± 27%	Explore
hematopoietic precursor cell	6 studies	76% ± 28%	Explore
kidney loop of Henle epithelial cell	6 studies	83% ± 17%	Explore
renal alpha-intercalated cell	6 studies	96% ± 5%	Explore
megakaryocyte	6 studies	90% ± 16%	Explore
enteroendocrine cell	6 studies	85% ± 16%	Explore
erythroblast	6 studies	76% ± 27%	Explore
transit amplifying cell	6 studies	86% ± 17%	Explore
retinal ganglion cell	6 studies	82% ± 19%	Explore
lymphocyte	6 studies	78% ± 30%	Explore
precursor B cell	6 studies	99% ± 1%	Explore
immature B cell	6 studies	99% ± 1%	Explore
amacrine cell	6 studies	56% ± 25%	Explore
adipocyte	6 studies	29% ± 8%	Explore
Mueller cell	6 studies	61% ± 32%	Explore
intermediate monocyte	6 studies	96% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	93% ± 11%	Explore
granulocyte	6 studies	96% ± 4%	Explore
melanocyte	6 studies	83% ± 26%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	90% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	96% ± 7%	Explore
duct epithelial cell	5 studies	77% ± 30%	Explore
exhausted T cell	5 studies	98% ± 4%	Explore
kidney connecting tubule epithelial cell	5 studies	78% ± 32%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	96% ± 4%	Explore
retinal cone cell	5 studies	49% ± 19%	Explore
retinal rod cell	5 studies	37% ± 17%	Explore
renal principal cell	5 studies	66% ± 37%	Explore
neuroendocrine cell	5 studies	90% ± 9%	Explore
Schwann cell	5 studies	68% ± 34%	Explore
T-helper 17 cell	5 studies	99% ± 1%	Explore
group 3 innate lymphoid cell	5 studies	99% ± 1%	Explore
retina horizontal cell	5 studies	61% ± 23%	Explore
mucus secreting cell	5 studies	62% ± 23%	Explore
cardiac muscle cell	5 studies	55% ± 11%	Explore
inflammatory macrophage	5 studies	88% ± 10%	Explore
muscle cell	5 studies	60% ± 32%	Explore
double negative thymocyte	5 studies	100% ± 0%	Explore
myoepithelial cell	5 studies	83% ± 21%	Explore
hepatocyte	5 studies	66% ± 22%	Explore
keratinocyte	5 studies	80% ± 29%	Explore
deuterosomal cell	4 studies	69% ± 23%	Explore
precursor cell	4 studies	83% ± 28%	Explore
squamous epithelial cell	4 studies	81% ± 17%	Explore
pancreatic A cell	4 studies	88% ± 8%	Explore
type B pancreatic cell	4 studies	83% ± 15%	Explore
monocyte-derived dendritic cell	4 studies	98% ± 3%	Explore
cholangiocyte	4 studies	41% ± 27%	Explore
endothelial cell of sinusoid	4 studies	54% ± 26%	Explore
glomerular endothelial cell	4 studies	81% ± 11%	Explore
podocyte	4 studies	98% ± 2%	Explore
renal beta-intercalated cell	4 studies	78% ± 35%	Explore
intestinal crypt stem cell	4 studies	93% ± 6%	Explore
granule cell	4 studies	40% ± 19%	Explore
OFF-bipolar cell	4 studies	48% ± 31%	Explore
ON-bipolar cell	4 studies	55% ± 28%	Explore
GABAergic amacrine cell	4 studies	54% ± 19%	Explore
glycinergic amacrine cell	4 studies	40% ± 21%	Explore
pro-B cell	4 studies	99% ± 1%	Explore
chondrocyte	4 studies	69% ± 19%	Explore
retinal pigment epithelial cell	4 studies	77% ± 17%	Explore
adventitial cell	4 studies	91% ± 12%	Explore
acinar cell	4 studies	68% ± 20%	Explore
germinal center B cell	4 studies	100% ± 0%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	94% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	77% ± 26%	Explore
IgM plasma cell	4 studies	64% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	79% ± 36%	Explore
T-helper 1 cell	4 studies	100% ± 0%	Explore
Langerhans cell	3 studies	99% ± 1%	Explore
hillock cell	3 studies	73% ± 34%	Explore
pancreatic D cell	3 studies	87% ± 14%	Explore
hepatic stellate cell	3 studies	39% ± 19%	Explore
renal intercalated cell	3 studies	85% ± 7%	Explore
parietal epithelial cell	3 studies	65% ± 36%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	75% ± 25%	Explore
neural crest cell	3 studies	99% ± 2%	Explore
paneth cell	3 studies	83% ± 12%	Explore
GABAergic interneuron	3 studies	29% ± 7%	Explore
thymocyte	3 studies	94% ± 4%	Explore
extravillous trophoblast	3 studies	99% ± 0%	Explore
placental villous trophoblast	3 studies	97% ± 3%	Explore
retinal bipolar neuron	3 studies	50% ± 23%	Explore
serous secreting cell	3 studies	61% ± 14%	Explore
tissue-resident macrophage	3 studies	84% ± 21%	Explore
follicular B cell	3 studies	95% ± 5%	Explore
intraepithelial lymphocyte	3 studies	100% ± 0%	Explore
rod bipolar cell	3 studies	46% ± 20%	Explore
pancreatic ductal cell	3 studies	95% ± 4%	Explore
neural progenitor cell	3 studies	44% ± 26%	Explore
ependymal cell	3 studies	35% ± 20%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	99% ± 0%	Explore
double-positive, alpha-beta thymocyte	3 studies	100% ± 0%	Explore
progenitor cell of mammary luminal epithelium	3 studies	99% ± 1%	Explore
mural cell	3 studies	68% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	22 studies	57% ± 20%	Explore
peripheral blood	21 studies	91% ± 13%	Explore
lung	20 studies	85% ± 16%	Explore
intestine	14 studies	80% ± 21%	Explore
eye	11 studies	51% ± 24%	Explore
liver	9 studies	65% ± 27%	Explore
kidney	9 studies	83% ± 17%	Explore
lymph node	7 studies	94% ± 10%	Explore
heart	7 studies	45% ± 16%	Explore
bone marrow	6 studies	77% ± 29%	Explore
uterus	6 studies	77% ± 29%	Explore
pancreas	5 studies	78% ± 19%	Explore
esophagus	5 studies	63% ± 31%	Explore
prostate	5 studies	71% ± 32%	Explore
skin	5 studies	69% ± 34%	Explore
breast	5 studies	79% ± 30%	Explore
placenta	4 studies	82% ± 26%	Explore
adipose	4 studies	55% ± 28%	Explore
stomach	4 studies	56% ± 24%	Explore
ovary	3 studies	63% ± 22%	Explore
adrenal gland	3 studies	79% ± 23%	Explore
thymus	3 studies	83% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	444015.38	1445 / 1445	100%	5035.53	183 / 183
intestine	100%	461568.82	966 / 966	100%	4607.09	527 / 527
uterus	100%	379303.55	170 / 170	100%	4389.48	459 / 459
bladder	100%	388319.43	21 / 21	100%	4229.19	503 / 504
breast	100%	209903.81	459 / 459	100%	3947.77	1115 / 1118
lung	99%	282697.16	575 / 578	100%	4294.41	1155 / 1155
skin	98%	214479.84	1776 / 1809	100%	4436.85	472 / 472
prostate	98%	232560.92	239 / 245	100%	2443.52	501 / 502
ovary	97%	159476.06	175 / 180	100%	3698.13	430 / 430
thymus	95%	129596.53	622 / 653	100%	2906.13	604 / 605
adrenal gland	94%	112431.84	242 / 258	99%	1847.39	227 / 230
kidney	92%	125347.55	82 / 89	100%	2840.43	899 / 901
stomach	88%	241235.81	316 / 359	100%	4553.83	286 / 286
brain	84%	95616.66	2213 / 2642	100%	3832.41	705 / 705
liver	55%	56174.85	124 / 226	99%	1886.28	403 / 406
pancreas	21%	18166.21	69 / 328	99%	4235.84	177 / 178
blood vessel	100%	575151.59	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	1862.36	80 / 80
lymph node	0%	0	0 / 0	100%	8271.88	29 / 29
tonsil	0%	0	0 / 0	100%	3952.35	45 / 45
ureter	0%	0	0 / 0	100%	2574.37	1 / 1
adipose	100%	236671.02	1202 / 1204	0%	0	0 / 0
spleen	100%	265211.01	240 / 241	0%	0	0 / 0
peripheral blood	99%	485968.59	919 / 929	0%	0	0 / 0
heart	66%	75768.35	564 / 861	0%	0	0 / 0
muscle	12%	9797.76	98 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048870	Biological process	cell motility
GO_0030071	Biological process	regulation of mitotic metaphase/anaphase transition
GO_0070527	Biological process	platelet aggregation
GO_0051621	Biological process	regulation of norepinephrine uptake
GO_2000819	Biological process	regulation of nucleotide-excision repair
GO_0032091	Biological process	negative regulation of protein binding
GO_0051726	Biological process	regulation of cell cycle
GO_2000779	Biological process	regulation of double-strand break repair
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0007163	Biological process	establishment or maintenance of cell polarity
GO_0045663	Biological process	positive regulation of myoblast differentiation
GO_0042981	Biological process	regulation of apoptotic process
GO_0001738	Biological process	morphogenesis of a polarized epithelium
GO_1903076	Biological process	regulation of protein localization to plasma membrane
GO_0072749	Biological process	cellular response to cytochalasin B
GO_0045582	Biological process	positive regulation of T cell differentiation
GO_0000079	Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0045176	Biological process	apical protein localization
GO_0007409	Biological process	axonogenesis
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_1905168	Biological process	positive regulation of double-strand break repair via homologous recombination
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_2000781	Biological process	positive regulation of double-strand break repair
GO_0034333	Biological process	adherens junction assembly
GO_1900242	Biological process	regulation of synaptic vesicle endocytosis
GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_0098974	Biological process	postsynaptic actin cytoskeleton organization
GO_0006338	Biological process	chromatin remodeling
GO_0071896	Biological process	protein localization to adherens junction
GO_0070316	Biological process	regulation of G0 to G1 transition
GO_1902459	Biological process	positive regulation of stem cell population maintenance
GO_0051623	Biological process	positive regulation of norepinephrine uptake
GO_0035633	Biological process	maintenance of blood-brain barrier
GO_0021762	Biological process	substantia nigra development
GO_0045596	Biological process	negative regulation of cell differentiation
GO_0022898	Biological process	regulation of transmembrane transporter activity
GO_0150111	Biological process	regulation of transepithelial transport
GO_0098978	Cellular component	glutamatergic synapse
GO_0071565	Cellular component	nBAF complex
GO_0098793	Cellular component	presynapse
GO_0005856	Cellular component	cytoskeleton
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0097433	Cellular component	dense body
GO_0043296	Cellular component	apical junction complex
GO_0005634	Cellular component	nucleus
GO_0000786	Cellular component	nucleosome
GO_0071564	Cellular component	npBAF complex
GO_0070062	Cellular component	extracellular exosome
GO_0016514	Cellular component	SWI/SNF complex
GO_0005654	Cellular component	nucleoplasm
GO_0016586	Cellular component	RSC-type complex
GO_0030863	Cellular component	cortical cytoskeleton
GO_0015629	Cellular component	actin cytoskeleton
GO_0005912	Cellular component	adherens junction
GO_0098871	Cellular component	postsynaptic actin cytoskeleton
GO_1990904	Cellular component	ribonucleoprotein complex
GO_0030027	Cellular component	lamellipodium
GO_0140092	Cellular component	bBAF complex
GO_0005615	Cellular component	extracellular space
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0032991	Cellular component	protein-containing complex
GO_0005884	Cellular component	actin filament
GO_0072562	Cellular component	blood microparticle
GO_0035060	Cellular component	brahma complex
GO_0044305	Cellular component	calyx of Held
GO_0005737	Cellular component	cytoplasm
GO_0030424	Cellular component	axon
GO_0000785	Cellular component	chromatin
GO_0005903	Cellular component	brush border
GO_0140288	Cellular component	GBAF complex
GO_0070160	Cellular component	tight junction
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0000776	Cellular component	kinetochore
GO_0005925	Cellular component	focal adhesion
GO_0035267	Cellular component	NuA4 histone acetyltransferase complex
GO_0005911	Cellular component	cell-cell junction
GO_0016363	Cellular component	nuclear matrix
GO_0005829	Cellular component	cytosol
GO_0045202	Cellular component	synapse
GO_0031982	Cellular component	vesicle
GO_0031492	Molecular function	nucleosomal DNA binding
GO_0050998	Molecular function	nitric-oxide synthase binding
GO_0042802	Molecular function	identical protein binding
GO_0005524	Molecular function	ATP binding
GO_0048156	Molecular function	tau protein binding
GO_0019894	Molecular function	kinesin binding
GO_0030957	Molecular function	Tat protein binding
GO_0005515	Molecular function	protein binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0019901	Molecular function	protein kinase binding
GO_0098973	Molecular function	structural constituent of postsynaptic actin cytoskeleton
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	ACTB
Protein name	Beta actin Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] Actin, cytoplasmic 1 ACTB protein Actin beta (HCG15971, isoform CRA_b) Actin, cytoplasmic 1 (Beta-actin) Actin beta Beta-actin
Synonyms	hCG_15971
Description	FUNCTION: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells . Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction . In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA . Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). .
Accessions	ENST00000473257.3 ENST00000674681.1 ENST00000443528.5 A0A510GJR4 ENST00000642480.2 ENST00000642480 ENST00000646664.1 C9JUM1 E7EVS6 ENST00000676189.1 ENST00000464611.1 C9JZR7 G8FSY7 ENST00000645576.1 ENST00000425660.5 ENST00000676319.1 Q9UMN3 A0A6Q8PH58 ENST00000675515.1 A0A2R8YFE2 G5E9R0 P60709 ENST00000417101.2 ENST00000414620.1 A0A6Q8PFE4 C9JTX5 ENST00000647275.1 A0A2R8Y793 ENST00000432588.6 ENST00000493945.6 A0AUL6 A0A2R8YGF8 ENST00000676397.1 A0A2R8YEA7 A0A6Q8PGD7

ACTB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review