HTR6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of HTR6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HTR6 at tissue level.

III. Associated gene sets

GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0007268Biological processchemical synaptic transmission
GO_0098664Biological processG protein-coupled serotonin receptor signaling pathway
GO_0032008Biological processpositive regulation of TOR signaling
GO_0021795Biological processcerebral cortex cell migration
GO_0007187Biological processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO_0005929Cellular componentcilium
GO_0030425Cellular componentdendrite
GO_0045202Cellular componentsynapse
GO_0005886Cellular componentplasma membrane
GO_0004993Molecular functionG protein-coupled serotonin receptor activity
GO_0030594Molecular functionneurotransmitter receptor activity
GO_0005515Molecular functionprotein binding
GO_0004969Molecular functionhistamine receptor activity

IV. Literature review

[source]
Gene nameHTR6
Protein name5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6)
Synonyms
DescriptionFUNCTION: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling . .

AccessionsP50406
ENST00000289753.2