VAMP2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	43% ± 15%	Explore
B cell	31 studies	40% ± 16%	Explore
fibroblast	28 studies	37% ± 14%	Explore
CD8-positive, alpha-beta T cell	28 studies	40% ± 17%	Explore
endothelial cell	27 studies	38% ± 14%	Explore
CD4-positive, alpha-beta T cell	27 studies	41% ± 18%	Explore
T cell	26 studies	37% ± 14%	Explore
pericyte	25 studies	44% ± 17%	Explore
smooth muscle cell	24 studies	39% ± 13%	Explore
regulatory T cell	18 studies	35% ± 15%	Explore
naive B cell	16 studies	39% ± 17%	Explore
gamma-delta T cell	16 studies	40% ± 14%	Explore
memory B cell	16 studies	41% ± 19%	Explore
mast cell	15 studies	32% ± 11%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 10%	Explore
mature NK T cell	15 studies	42% ± 13%	Explore
connective tissue cell	15 studies	32% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	49% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	43% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	44% ± 22%	Explore
classical monocyte	13 studies	35% ± 20%	Explore
conventional dendritic cell	13 studies	35% ± 21%	Explore
astrocyte	13 studies	38% ± 18%	Explore
mucosal invariant T cell	13 studies	36% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	43% ± 22%	Explore
myofibroblast cell	12 studies	40% ± 13%	Explore
plasmacytoid dendritic cell	12 studies	37% ± 14%	Explore
basal cell	12 studies	35% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	42% ± 22%	Explore
capillary endothelial cell	11 studies	27% ± 9%	Explore
monocyte	10 studies	23% ± 8%	Explore
macrophage	10 studies	22% ± 6%	Explore
endothelial cell of artery	10 studies	26% ± 9%	Explore
plasma cell	10 studies	33% ± 11%	Explore
endothelial cell of vascular tree	10 studies	34% ± 9%	Explore
non-classical monocyte	9 studies	39% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	49% ± 25%	Explore
epithelial cell	9 studies	37% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	39% ± 21%	Explore
vein endothelial cell	8 studies	24% ± 7%	Explore
T follicular helper cell	8 studies	42% ± 18%	Explore
retinal rod cell	8 studies	62% ± 28%	Explore
microglial cell	8 studies	28% ± 12%	Explore
oligodendrocyte	8 studies	39% ± 10%	Explore
oligodendrocyte precursor cell	8 studies	39% ± 18%	Explore
type I pneumocyte	7 studies	34% ± 15%	Explore
leukocyte	7 studies	30% ± 6%	Explore
glutamatergic neuron	7 studies	61% ± 20%	Explore
goblet cell	7 studies	30% ± 14%	Explore
amacrine cell	7 studies	69% ± 25%	Explore
dendritic cell	7 studies	35% ± 21%	Explore
myeloid cell	7 studies	34% ± 21%	Explore
type II pneumocyte	6 studies	28% ± 16%	Explore
retina horizontal cell	6 studies	69% ± 25%	Explore
retinal ganglion cell	6 studies	70% ± 33%	Explore
retinal cone cell	6 studies	76% ± 26%	Explore
precursor B cell	6 studies	42% ± 21%	Explore
ciliated cell	6 studies	33% ± 10%	Explore
neuron	6 studies	58% ± 23%	Explore
secretory cell	6 studies	23% ± 8%	Explore
ionocyte	5 studies	29% ± 12%	Explore
kidney loop of Henle epithelial cell	5 studies	35% ± 8%	Explore
renal alpha-intercalated cell	5 studies	48% ± 9%	Explore
enteroendocrine cell	5 studies	44% ± 23%	Explore
ON-bipolar cell	5 studies	72% ± 32%	Explore
abnormal cell	5 studies	34% ± 11%	Explore
pro-B cell	5 studies	43% ± 22%	Explore
immature B cell	5 studies	49% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	45% ± 21%	Explore
innate lymphoid cell	5 studies	41% ± 13%	Explore
GABAergic neuron	5 studies	55% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	31% ± 3%	Explore
mononuclear phagocyte	4 studies	31% ± 18%	Explore
exhausted T cell	4 studies	38% ± 20%	Explore
glomerular endothelial cell	4 studies	39% ± 9%	Explore
podocyte	4 studies	75% ± 8%	Explore
epithelial cell of proximal tubule	4 studies	22% ± 5%	Explore
mesothelial cell	4 studies	54% ± 20%	Explore
retinal bipolar neuron	4 studies	75% ± 30%	Explore
OFF-bipolar cell	4 studies	83% ± 21%	Explore
hematopoietic stem cell	4 studies	43% ± 22%	Explore
neuroendocrine cell	4 studies	62% ± 22%	Explore
Mueller cell	4 studies	61% ± 17%	Explore
CD4-positive helper T cell	4 studies	37% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 12%	Explore
granulocyte	4 studies	27% ± 13%	Explore
brush cell	4 studies	32% ± 13%	Explore
interneuron	4 studies	53% ± 23%	Explore
pancreatic A cell	3 studies	83% ± 6%	Explore
type B pancreatic cell	3 studies	79% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	28% ± 3%	Explore
hematopoietic precursor cell	3 studies	58% ± 21%	Explore
plasmablast	3 studies	47% ± 22%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	37% ± 10%	Explore
neural crest cell	3 studies	36% ± 5%	Explore
IgG plasma cell	3 studies	23% ± 3%	Explore
GABAergic amacrine cell	3 studies	80% ± 14%	Explore
glycinergic amacrine cell	3 studies	76% ± 20%	Explore
thymocyte	3 studies	29% ± 13%	Explore
lymphocyte	3 studies	37% ± 10%	Explore
club cell	3 studies	33% ± 14%	Explore
enterocyte	3 studies	22% ± 1%	Explore
retinal pigment epithelial cell	3 studies	48% ± 27%	Explore
intraepithelial lymphocyte	3 studies	33% ± 6%	Explore
rod bipolar cell	3 studies	84% ± 14%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	45% ± 21%	Explore
glial cell	3 studies	43% ± 25%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 11%	Explore
T-helper 17 cell	3 studies	51% ± 11%	Explore
neutrophil	3 studies	25% ± 1%	Explore
T-helper 1 cell	3 studies	56% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	35% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	46% ± 29%	Explore
double negative thymocyte	3 studies	44% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	13 studies	35% ± 12%	Explore
peripheral blood	13 studies	44% ± 16%	Explore
brain	11 studies	43% ± 18%	Explore
intestine	10 studies	31% ± 15%	Explore
eye	9 studies	62% ± 26%	Explore
kidney	7 studies	26% ± 5%	Explore
lymph node	5 studies	29% ± 16%	Explore
uterus	4 studies	35% ± 4%	Explore
breast	4 studies	28% ± 10%	Explore
liver	4 studies	36% ± 12%	Explore
pancreas	3 studies	65% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	29640.79	2642 / 2642	100%	260.16	705 / 705
thymus	100%	9947.22	653 / 653	100%	113.63	605 / 605
prostate	100%	10113.14	245 / 245	100%	110.13	501 / 502
ovary	100%	14945.83	180 / 180	100%	51.71	428 / 430
breast	100%	8940.03	459 / 459	98%	67.87	1100 / 1118
kidney	100%	9596.98	89 / 89	98%	71.97	886 / 901
adrenal gland	100%	11161.36	258 / 258	96%	178.72	221 / 230
skin	97%	8426.93	1753 / 1809	99%	69.59	468 / 472
lung	99%	8141.44	575 / 578	96%	43.05	1114 / 1155
uterus	100%	12576.42	170 / 170	95%	42.87	437 / 459
esophagus	100%	7672.20	1438 / 1445	95%	35.60	173 / 183
bladder	100%	7576.95	21 / 21	93%	38.47	471 / 504
pancreas	94%	4014.03	309 / 328	99%	71.21	176 / 178
intestine	100%	8416.74	966 / 966	91%	31.97	481 / 527
stomach	100%	6556.84	359 / 359	91%	32.39	259 / 286
liver	69%	2210.73	156 / 226	77%	25.91	313 / 406
lymph node	0%	0	0 / 0	100%	54.57	29 / 29
spleen	100%	10497.69	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	43.45	45 / 45
blood vessel	100%	11663.18	1334 / 1335	0%	0	0 / 0
adipose	100%	8094.46	1203 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	84.83	79 / 80
muscle	98%	5287.43	790 / 803	0%	0	0 / 0
heart	98%	5842.68	842 / 861	0%	0	0 / 0
peripheral blood	96%	6830.85	891 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1902259	Biological process	regulation of delayed rectifier potassium channel activity
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0009749	Biological process	response to glucose
GO_0043308	Biological process	eosinophil degranulation
GO_0048488	Biological process	synaptic vesicle endocytosis
GO_0017156	Biological process	calcium-ion regulated exocytosis
GO_0061025	Biological process	membrane fusion
GO_0060627	Biological process	regulation of vesicle-mediated transport
GO_0017157	Biological process	regulation of exocytosis
GO_0016079	Biological process	synaptic vesicle exocytosis
GO_0060291	Biological process	long-term synaptic potentiation
GO_0035493	Biological process	SNARE complex assembly
GO_0065003	Biological process	protein-containing complex assembly
GO_1903593	Biological process	regulation of histamine secretion by mast cell
GO_0016192	Biological process	vesicle-mediated transport
GO_0006887	Biological process	exocytosis
GO_0043312	Biological process	neutrophil degranulation
GO_0043320	Biological process	natural killer cell degranulation
GO_0015031	Biological process	protein transport
GO_0006906	Biological process	vesicle fusion
GO_0070254	Biological process	mucus secretion
GO_0043001	Biological process	Golgi to plasma membrane protein transport
GO_0090316	Biological process	positive regulation of intracellular protein transport
GO_0070032	Cellular component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO_0030667	Cellular component	secretory granule membrane
GO_0060203	Cellular component	clathrin-sculpted glutamate transport vesicle membrane
GO_0061202	Cellular component	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0030136	Cellular component	clathrin-coated vesicle
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0070033	Cellular component	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO_0043005	Cellular component	neuron projection
GO_0005802	Cellular component	trans-Golgi network
GO_0005829	Cellular component	cytosol
GO_0008021	Cellular component	synaptic vesicle
GO_0045202	Cellular component	synapse
GO_0042589	Cellular component	zymogen granule membrane
GO_0070083	Cellular component	clathrin-sculpted monoamine transport vesicle membrane
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0070044	Cellular component	synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO_0030141	Cellular component	secretory granule
GO_0031982	Cellular component	vesicle
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_0031201	Cellular component	SNARE complex
GO_0044306	Cellular component	neuron projection terminus
GO_0005543	Molecular function	phospholipid binding
GO_0017075	Molecular function	syntaxin-1 binding
GO_0048306	Molecular function	calcium-dependent protein binding
GO_0000149	Molecular function	SNARE binding
GO_0005516	Molecular function	calmodulin binding
GO_0005484	Molecular function	SNAP receptor activity
GO_0005515	Molecular function	protein binding
GO_0019905	Molecular function	syntaxin binding

IV. Literature review

[source]

Gene name	VAMP2
Protein name	Vesicle-associated membrane protein 2 (Synaptobrevin-2) Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin-2) Vesicle associated membrane protein 2
Synonyms	SYB2
Description	FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity) . Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. .
Accessions	P63027 A0AA34QW14 K7ENK9 F8WCA0 ENST00000481878.1 ENST00000404970.3 ENST00000488857.5 J3QRU4 ENST00000711100.1 ENST00000316509.11

VAMP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review