I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 8 studies | 35% ± 15% | |
| GABAergic neuron | 5 studies | 26% ± 13% | |
| interneuron | 4 studies | 30% ± 12% | |
| glutamatergic neuron | 3 studies | 28% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| oligodendrocyte precursor cell | 8 studies | 35% ± 15% | |
| GABAergic neuron | 5 studies | 26% ± 13% | |
| interneuron | 4 studies | 30% ± 12% | |
| glutamatergic neuron | 3 studies | 28% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 26% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 99% | 1591.26 | 2619 / 2642 | 53% | 2.18 | 375 / 705 |
| prostate | 71% | 412.56 | 173 / 245 | 30% | 0.66 | 150 / 502 |
| muscle | 99% | 4119.12 | 798 / 803 | 0% | 0 | 0 / 0 |
| kidney | 82% | 592.72 | 73 / 89 | 3% | 0.95 | 27 / 901 |
| lung | 62% | 273.75 | 360 / 578 | 22% | 1.47 | 259 / 1155 |
| esophagus | 51% | 268.88 | 742 / 1445 | 32% | 2.73 | 59 / 183 |
| skin | 69% | 724.95 | 1256 / 1809 | 3% | 0.16 | 12 / 472 |
| intestine | 65% | 828.15 | 626 / 966 | 3% | 0.06 | 17 / 527 |
| pancreas | 60% | 203.81 | 196 / 328 | 4% | 0.08 | 8 / 178 |
| stomach | 24% | 116.14 | 85 / 359 | 9% | 0.20 | 25 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 24% | 1.00 | 11 / 45 |
| thymus | 16% | 60.59 | 102 / 653 | 4% | 0.15 | 23 / 605 |
| ovary | 1% | 2.32 | 2 / 180 | 17% | 0.52 | 73 / 430 |
| uterus | 4% | 11.78 | 6 / 170 | 13% | 0.41 | 59 / 459 |
| adrenal gland | 0% | 0 | 0 / 258 | 14% | 2.66 | 32 / 230 |
| bladder | 0% | 0 | 0 / 21 | 4% | 0.18 | 22 / 504 |
| breast | 3% | 12.10 | 12 / 459 | 1% | 0.10 | 12 / 1118 |
| adipose | 3% | 14.72 | 41 / 1204 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 2% | 0.05 | 7 / 406 |
| blood vessel | 1% | 2.04 | 9 / 1335 | 0% | 0 | 0 / 0 |
| heart | 0% | 1.04 | 4 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.75 | 2 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0045454 | Biological process | cell redox homeostasis |
| GO_1902307 | Biological process | positive regulation of sodium ion transmembrane transport |
| GO_0006941 | Biological process | striated muscle contraction |
| GO_1902514 | Biological process | regulation of calcium ion transmembrane transport via high voltage-gated calcium channel |
| GO_0010882 | Biological process | regulation of cardiac muscle contraction by calcium ion signaling |
| GO_0009408 | Biological process | response to heat |
| GO_0051612 | Biological process | negative regulation of serotonin uptake |
| GO_0002028 | Biological process | regulation of sodium ion transport |
| GO_0051926 | Biological process | negative regulation of calcium ion transport |
| GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0006527 | Biological process | arginine catabolic process |
| GO_0010523 | Biological process | negative regulation of calcium ion transport into cytosol |
| GO_0009725 | Biological process | response to hormone |
| GO_0042178 | Biological process | xenobiotic catabolic process |
| GO_0045776 | Biological process | negative regulation of blood pressure |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0033555 | Biological process | multicellular organismal response to stress |
| GO_0001666 | Biological process | response to hypoxia |
| GO_0006809 | Biological process | nitric oxide biosynthetic process |
| GO_0031284 | Biological process | positive regulation of guanylate cyclase activity |
| GO_0007263 | Biological process | nitric oxide mediated signal transduction |
| GO_0018119 | Biological process | peptidyl-cysteine S-nitrosylation |
| GO_0043267 | Biological process | negative regulation of potassium ion transport |
| GO_1905026 | Biological process | positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential |
| GO_0007520 | Biological process | myoblast fusion |
| GO_0098735 | Biological process | positive regulation of the force of heart contraction |
| GO_0042311 | Biological process | vasodilation |
| GO_0055117 | Biological process | regulation of cardiac muscle contraction |
| GO_0060314 | Biological process | regulation of ryanodine-sensitive calcium-release channel activity |
| GO_0106071 | Biological process | positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0051346 | Biological process | negative regulation of hydrolase activity |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0042383 | Cellular component | sarcolemma |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0001917 | Cellular component | photoreceptor inner segment |
| GO_0005829 | Cellular component | cytosol |
| GO_0071944 | Cellular component | cell periphery |
| GO_0016529 | Cellular component | sarcoplasmic reticulum |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0045202 | Cellular component | synapse |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0010181 | Molecular function | FMN binding |
| GO_0050660 | Molecular function | flavin adenine dinucleotide binding |
| GO_0004517 | Molecular function | nitric-oxide synthase activity |
| GO_0034617 | Molecular function | tetrahydrobiopterin binding |
| GO_0005246 | Molecular function | calcium channel regulator activity |
| GO_0046870 | Molecular function | cadmium ion binding |
| GO_0034618 | Molecular function | arginine binding |
| GO_0050661 | Molecular function | NADP binding |
| GO_0048306 | Molecular function | calcium-dependent protein binding |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0020037 | Molecular function | heme binding |
| GO_0044325 | Molecular function | transmembrane transporter binding |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0017080 | Molecular function | sodium channel regulator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NOS1 |
| Protein name | Alternative protein NOS1 Nitric oxide synthase 1 (EC 1.14.13.39) (Constitutive NOS) (NC-NOS) (NOS type I) (Neuronal NOS) (N-NOS) (nNOS) (Nitric oxide synthase, brain) (bNOS) (Peptidyl-cysteine S-nitrosylase NOS1) Nitric oxide synthase (EC 1.14.13.39) nitric-oxide synthase (NADPH) (EC 1.14.13.39) |
| Synonyms | hCG_40354 |
| Description | FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. . FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions. . |
| Accessions | A0PJJ7 ENST00000338101.8 [P29475-5] ENST00000618760.4 [P29475-5] B3VK56 P29475 ENST00000317775.11 [P29475-1] L8E6X1 |
