SLC8A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0086012Biological processmembrane depolarization during cardiac muscle cell action potential
GO_0055074Biological processcalcium ion homeostasis
GO_0035994Biological processresponse to muscle stretch
GO_0010468Biological processregulation of gene expression
GO_0010882Biological processregulation of cardiac muscle contraction by calcium ion signaling
GO_0097553Biological processcalcium ion transmembrane import into cytosol
GO_0055013Biological processcardiac muscle cell development
GO_0086064Biological processcell communication by electrical coupling involved in cardiac conduction
GO_0006811Biological processmonoatomic ion transport
GO_0098703Biological processcalcium ion import across plasma membrane
GO_0002026Biological processregulation of the force of heart contraction
GO_0002027Biological processregulation of heart rate
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0014829Biological processvascular associated smooth muscle contraction
GO_0006936Biological processmuscle contraction
GO_0006883Biological processintracellular sodium ion homeostasis
GO_0060048Biological processcardiac muscle contraction
GO_0055119Biological processrelaxation of cardiac muscle
GO_0010881Biological processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO_0070509Biological processcalcium ion import
GO_0044557Biological processrelaxation of smooth muscle
GO_0098719Biological processsodium ion import across plasma membrane
GO_0010649Biological processregulation of cell communication by electrical coupling
GO_0060402Biological processcalcium ion transport into cytosol
GO_1903779Biological processregulation of cardiac conduction
GO_0098735Biological processpositive regulation of the force of heart contraction
GO_0030501Biological processpositive regulation of bone mineralization
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0051481Biological processnegative regulation of cytosolic calcium ion concentration
GO_0071901Biological processnegative regulation of protein serine/threonine kinase activity
GO_0071313Biological processcellular response to caffeine
GO_0005886Cellular componentplasma membrane
GO_0030018Cellular componentZ disc
GO_0042383Cellular componentsarcolemma
GO_0043679Cellular componentaxon terminus
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0098794Cellular componentpostsynapse
GO_0030425Cellular componentdendrite
GO_0030315Cellular componentT-tubule
GO_0071944Cellular componentcell periphery
GO_0045202Cellular componentsynapse
GO_0014069Cellular componentpostsynaptic density
GO_0030424Cellular componentaxon
GO_0014704Cellular componentintercalated disc
GO_0044325Molecular functiontransmembrane transporter binding
GO_0030506Molecular functionankyrin binding
GO_0005432Molecular functioncalcium:sodium antiporter activity
GO_0005516Molecular functioncalmodulin binding
GO_0005509Molecular functioncalcium ion binding
GO_0008092Molecular functioncytoskeletal protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC8A1
Protein nameSolute carrier family 8 member A1
SLC8A1 protein
Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)
SynonymsNCX1
CNC
DescriptionFUNCTION: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes . Contributes to Ca(2+) transport during excitation-contraction coupling in muscle . In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum . SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline . Required for normal embryonic heart development and the onset of heart contractions (By similarity). .

AccessionsENST00000405269.5 [P32418-2]
A0A994J7E1
ENST00000705605.1
Q4QQH3
ENST00000406391.2 [P32418-2]
ENST00000332839.9 [P32418-1]
A0A994J7G2
A0A994J4U7
ENST00000705603.1
ENST00000417271.2
E9PCL8
ENST00000403092.5 [P32418-1]
ENST00000407929.6
ENST00000405901.7 [P32418-5]
ENST00000705282.1
ENST00000705283.1
ENST00000408028.6 [P32418-4]
ENST00000455476.5
ENST00000705225.1
A0A994J5G5
E7EV41
ENST00000705281.1
ENST00000448531.1
E9PB98
ENST00000406785.7 [P32418-2]
P32418
ENST00000705604.1 [P32418-3]
ENST00000402441.5 [P32418-2]